Inflammatory bowel disease: The asthma of the intestine?

Eliakim, Rami; Rachmilewitz, Daniel

doi:10.1002/ibd.3780020210

Cited by 4 publications

(2 citation statements)

References 117 publications

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“…In humans, similarities between the genesis of IBD and asthma have been noted (61). The current understanding is that both diseases are multifactorial and involve defects in multiple genes, which could interact with one another in a complex manner (62,63).…”

Section: Discussionmentioning

confidence: 99%

Loss of Runx3 function in leukocytes is associated with spontaneously developed colitis and gastric mucosal hyperplasia

Brenner

Levanon

Negreanu

et al. 2004

Proc. Natl. Acad. Sci. U.S.A.

159

146

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Section: Discussionmentioning

confidence: 99%

Loss of Runx3 function in leukocytes is associated with spontaneously developed colitis and gastric mucosal hyperplasia

Brenner

Levanon

Negreanu

et al. 2004

Proc. Natl. Acad. Sci. U.S.A.

159

146

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“…These include inflammatory bowel diseases (IBD) that affect 0.5% of the population of developed countries [ 4 ]. Analogies have been previously drawn between IBD and asthma [ 5 , 6 ], the risk of which is increased by approximately 50% in IBD patients [ 7 , 8 ]. This suggests that airway mucosal pathology could co-occur with intestinal mucosa dysfunction.…”

Section: Introductionmentioning

confidence: 80%

Expression profiling of ileal mucosa in asthma reveals upregulation of innate immunity and genes characteristic of Paneth and goblet cells

Nowak

Dworacka

Gubaj

et al. 2021

Allergy Asthma Clin Immunol

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Background The expression profiles of the intestinal mucosa have not been comprehensively investigated in asthma. We aimed to explore this in the Correlated Expression and Disease Association Research (CEDAR) patient cohort. Methods Differential expression analysis of ileal, transverse colon, and rectal biopsies were supplemented by a comparison of transcriptomes from platelets and leukocytes subsets, including CD4+, CD8+, CD14+, CD15+, and CD19+ cells. Asthma patients (n = 15) and controls (n = 15) had similar age (p = 0.967), body mass index (p = 0.870), similar numbers of females (80%) and smoking rates (13.3%). Results Significant differential expression was found in the ileum alone, and not in any other cell/tissue types. More genes were found to be overexpressed (1,150) than under-expressed (380). The most overexpressed genes included Fc Fragment of IgG Binding Protein (FCGBP, logFC = 3.01, pFDR = 0.015), Mucin 2 (MUC2, logFC = 2.78, pFDR = 0.015), and Alpha 1B Defensin (DEFA1B, logFC = 2.73, pFDR = 0.024). Gene ontology implicated the immune system, including interleukins 4 and 13, as well as antimicrobial peptides in this overexpression. There was concordance of gene over- (STAT1, XBP1) and underexpression (NELF, RARA) in asthma and Crohn’s disease ileum when our results were compared to another dataset (p = 3.66 × 10–7). Conclusion Ileal mucosa in asthma exhibits a specific transcriptomic profile, which includes the overexpression of innate immune genes, mostly characteristic of Paneth and goblet cells, in addition to other changes that may resemble Crohn’s disease.

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Novel Therapies for Inflammatory Bowel Disease

Sands

1999

Gastroenterology Clinics of North America

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Inflammatory bowel disease: The asthma of the intestine?

Cited by 4 publications

References 117 publications

Loss of Runx3 function in leukocytes is associated with spontaneously developed colitis and gastric mucosal hyperplasia

Loss of Runx3 function in leukocytes is associated with spontaneously developed colitis and gastric mucosal hyperplasia

Expression profiling of ileal mucosa in asthma reveals upregulation of innate immunity and genes characteristic of Paneth and goblet cells

Novel Therapies for Inflammatory Bowel Disease

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