Inflammatory Bowel Diseases in Children: Modern Achievements in Diagnostics and Therapy

Khavkin, A. I.; Nalyotov, A. V.; Marchenko, N. A.

doi:10.22416/1382-4376-2023-33-6-7-15

Rossijskij žurnal gastroènterologii, gepatologii, koloproktolog

2023

DOI: 10.22416/1382-4376-2023-33-6-7-15

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Inflammatory Bowel Diseases in Children: Modern Achievements in Diagnostics and Therapy

A. I. Khavkin,

A. V. Nalyotov,

N. A. Marchenko

Abstract: Aim: to highlight current trends in the diagnosis and treatment of inflammatory bowel diseases in children.Key points. The incidence of inflammatory bowel disease among children has increased significantly over the past three decades. Moreover, these diseases are often characterized by a severe course. At the same time, strategies for diagnosing and treating these patients are being improved: doctors began using high-definition endoscopy and video capsule endoscopy, the determination of fecal calprotectin, bio… Show more

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2024

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Cited by 3 publications

References 39 publications

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Anti-inflammatory Effects of Olive Oil and Its Components. Prospects of Application in the Treatment of Inflammatory Bowel Diseases

Khavkin,

Nalyotov,

Matsynina

2024

Pediatr. farmakol.

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In recent years, there has been a significant increase in the prevalence of inflammatory bowel diseases. Despite the significant progress made in the instrumental diagnosis of this group of diseases, their treatment in most cases remains formalized, based on fairly strict schemes. In this context, an urgent area of modern research is to study the effectiveness of the use of diet therapy and certain foods in order to modulate the activity of the inflammatory process, which allows avoiding adverse reactions of immunosuppressive, including immunobiological, therapy. Adherence to the Mediterranean diet has proven its effectiveness in the treatment of chronic non-infectious diseases. Recent studies have also established its benefits in the treatment of inflammatory bowel diseases. Recent studies have also established its benefits in the treatment of inflammatory bowel diseases. This article will present the results of modern research on the effect of the use of olive oil and its components on the course of inflammatory processes in the intestine. A number of studies conducted in vitro and in animal models have revealed the mechanisms by which olive oil and its components have a positive effect on the course of inflammation in the intestinal wall through anti-inflammatory, antioxidant, immunomodulatory and antitumor effects. Few clinical studies conducted on patients with inflammatory bowel diseases have shown the possibility of using diet therapy with the addition of olive oil in this group of patients as an additional treatment.

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Anti-inflammatory Effects of Olive Oil and Its Components. Prospects of Application in the Treatment of Inflammatory Bowel Diseases

Khavkin,

Nalyotov,

Matsynina

2024

Pediatr. farmakol.

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Inflammatory Bowel Diseases and Dairy Products

Khavkin,

Bogdanova,

Nalyotov

et al. 2024

Pediatr. farmakol.

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At the moment, in most countries of Europe and North America, there has been a steady increase in the prevalence of inflammatory bowel diseases (IBD). There is little data on the correlation between dairy consumption and the development of IBD, despite the likely biological mechanisms linking these products with the etiopathogenesis of the disease. The exclusion of dairy products from the diet is usually associated with the occurrence of dyspeptic symptoms when they are consumed, which may indicate an exacerbation of the inflammatory process in the intestine or the presence of lactase deficiency. Patients with IBD are characterized by a high prevalence of osteoporosis, and limiting the consumption of dairy products has an even greater negative effect on the state of bone mineral density. In turn, correction of diet therapy in patients with IBD in the presence of intolerance to dairy products should be an important part of the treatment and prevention of complications of the disease.

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Role of Vitamin D in the Pathogenesis of Inflammatory Bowel Diseases: Literature Review

Khavkin,

Nalyotov,

Masyuta

et al. 2024

Vopr. sovr. pediatr.

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The pathogenesis of inflammatory bowel diseases still remains unclear nowadays. Genetic disposition, impaired immune regulation, disturbance in intestinal microbiota composition, exposure to environmental factors are associated with the development of inflammation in intestinal mucosa and increased epithelial penetrance that define disease's development and progression. There is a theory in scientific literature that vitamin D deficiency (among other environmental factors) increases the risk of inflammatory bowel disease. However, the role of vitamin D in the development of gastrointestinal tract diseases remains poorly studied. This article presents current data on the vitamin D effect on the intestinal mucosa barrier function, on the immune system and on the intestinal microbiota in the context of inflammatory bowel diseases pathogenesis.

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Inflammatory Bowel Diseases in Children: Modern Achievements in Diagnostics and Therapy

Cited by 3 publications

References 39 publications

Anti-inflammatory Effects of Olive Oil and Its Components. Prospects of Application in the Treatment of Inflammatory Bowel Diseases

Anti-inflammatory Effects of Olive Oil and Its Components. Prospects of Application in the Treatment of Inflammatory Bowel Diseases

Inflammatory Bowel Diseases and Dairy Products

Role of Vitamin D in the Pathogenesis of Inflammatory Bowel Diseases: Literature Review

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