Inflammatory Bowel Diseases With Very Early Onset

Shchigoleva, A.E.; Shumilov, P.V.; Shumilov, А.Р.

doi:10.24110/0031-403x-2018-97-6-141-146

Cited by 7 publications

(1 citation statement)

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“…Так, педіатрами відмічено зміщення дебюту ВК на більш ранній вік дитини, збільшення числа тотальних форм хвороби, повільний розвиток дебюту, відсутність кореляції між клінічними, лабораторними та ендоскопічними критеріями активності запального процесу [2,12,16,19,21].…”

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Clinical Forms of Ulcerative Colitis and Their Features in Children

Денисова¹,

Букулова²

2020

RS Global - Science Review

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This article presents frequency of occurrence of clinical forms of the disease depending on the localization and activity of the inflammatory process, their age and gender differences, risk factors and disease triggers, based on a retrospective analysis of 116 cases of children with ulcerative colitis at the age of 4-18 years. Comparative clinical, laboratory and endoscopic characteristics of total, segmental and distal colitis have been also analyzed. It was found that clinical activity of total colitis is characterized by more severe course of the disease, accompanied with systemic and local extraintestinal manifestations (OR = 4,504±0,506, p<0.05), more pronounced changes in hemo- and proteinogram parameters (p<0.05). Endoscopic criteria for differences in the clinical forms of ulcerative colitis are the presence of ulcers (OR = 9,667±0,645, p <0,05), erosions (OR = 3,569±0,429, p<0,05), contact bleeding (OR = 4,364± ,444, p< 0.05), changes in the vascular pattern (OR = 3,748±0,477, p<0.05). Correlation analysis of the relationship between clinical (PUCAI), endoscopic (Rachmilewitz index) and laboratory markers of the inflammatory process (leukocytes, platelets, erythrocyte sedimentation rate, γ-globulins, fecal calprotectin, hemoglobin) has been also performed, the criteria of which might be used to monitor the course of the disease and the effectiveness of therapy.

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Clinical Forms of Ulcerative Colitis and Their Features in Children

Денисова¹,

Букулова²

2020

RS Global - Science Review

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Chronic Diarrhea as a Debut Manifestation of Crohn’s Disease in Infant: Clinical Case

Коновалова

Pechkurov

Tyazheva

2023

Vopr. sovr. pediatr.

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Background. Chronic diarrhea can be a symptom of a wide variety of diseases, either of which requires special therapy approaches. The diagnosis of rare causes of chronic diarrhea is especially difficulty as it may be associated with inflammatory bowel disease (IBD) with very early (under 1 year of age) debut.Clinical case description. Boy E. had chronic diarrhea manifested on the first year of life. Ulcerative colitis was diagnosed at the age of 1.5 years, then the diagnosis was changed to Crohn’s disease at the age of 2.5 years. The results of 6-years-follow-up of the patient were presented, as well as analysis of diagnosis and treatment difficulties was carried out.Conclusion. The clinical case of Crohn’s disease with diarrhea as the leading clinical manifestation at the disease onset is described. Sequential diagnostic search allowed us to establish the diagnosis of IBD and to exclude other causes of chronic diarrhea that determined the correct therapeutic strategy.

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Modern View on Very Early Onset and Early Onset Inflammatory Bowel Diseases in Children

Khavkin,

Permyakova,

Tsepilova

et al. 2024

Vopr. sovr. pediatr.

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Nowadays, an urgent problem of pediatric gastroenterology is the study of inflammatory bowel diseases with very early onset (VEO-IBD), which have unique genetic, clinical, immunological, morphological, and laboratory sings. Early VEO-IBD is usually considered as monogenic disease, especially in combination with congenital immune defects, which leads to difficulties in diagnosis and management this pathology. Despite this, systematization of information about this group of nosological forms of IBD is practically not carried out. This article presents a review of the available information on etiological factors, course variants, and therapeutic options for VEO-IBD.

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Inflammatory Bowel Diseases With Very Early Onset

Cited by 7 publications

References 0 publications

Clinical Forms of Ulcerative Colitis and Their Features in Children

Clinical Forms of Ulcerative Colitis and Their Features in Children

Chronic Diarrhea as a Debut Manifestation of Crohn’s Disease in Infant: Clinical Case

Modern View on Very Early Onset and Early Onset Inflammatory Bowel Diseases in Children

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