Inflammatory linear verrucous epidermal nevus and arthritis: A new association

Al-Enezi, S. M.; Huber, Adam M.; Krafchik, Bernice R.; Laxer, Ronald M.

doi:10.1067/mpd.2001.112173

Cited by 19 publications

(12 citation statements)

References 13 publications

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“…Favoring the mentioned literature, ILVEN has been described previously in association with other disorders, including autoimmune thyroiditis [20] lichen amyloidosis [21], HIV1 infection [22], and skeletal defects [23] although this last association is in dispute [24]. Besides, two children with the combination of ILVEN and arthritis were reported [25]. In the present case, coexistence of ILVEN and HPV infection establishes clues about immunological basis of ILVEN.…”

Section: Discussionmentioning

confidence: 59%

Vulvar and Perianal Condyloma Superimposed Inflammatory Linear Verrucous Epidermal Nevus: A Case Report and Review of the Literature

Avcıoğlu

Altınkaya

Küçük

et al. 2013

Case Reports in Dermatological Medicine

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Inflammatory linear verrucous epidermal nevus (ILVEN) is a benign cutaneous hamartoma characterized by intensely erythematous, pruritic, and inflammatory papules that occur as linear bands along the lines of Blaschko. There is a considerable clinical and histological resemblance between ILVEN and linear psoriasis, lichen striatus, linear lichen planus, and invasion of epidermal nevus by psoriasis. The pathogenesis of ILVEN is unknown. It is regarded as a genetic dyskeratotic disease reflecting genetic mosaicism. Here, a case of vulvar and perianal condyloma superimposed ILVEN is presented.

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Section: Discussionmentioning

confidence: 59%

Vulvar and Perianal Condyloma Superimposed Inflammatory Linear Verrucous Epidermal Nevus: A Case Report and Review of the Literature

Avcıoğlu

Altınkaya

Küçük

et al. 2013

Case Reports in Dermatological Medicine

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“…Atherton et al [4] argued that epidermal nevus may, as a result of the postzygotic mutation, provide ‘fertile sites’ which offer a facilitated development of psoriasiform inflammation. The observation of Al-Enezi et al [13], who in 2001 reported 2 girls with an ILVEN appearing shortly after birth, followed by the development of juvenile psoriatic arthritis but no other skin signs of psoriasis (with the exception of some nail pitting in one of the girls with a positive family history) supports such considerations.…”

Section: Introductionmentioning

confidence: 58%

“…In other words, ILVEN unites histologically the characteristics of a (verrucous) epidermal nevus with a superimposed subacute eczema [36]. Cases interpreted by their authors as representing ILVEN which do not respond completely to anti-inflammatory/antipsoriatic treatment [13,20,21,22] are described as a preexisting (verrucous) epidermal nevus with a sudden onset of a pruritic inflammation. In these cases, it is only the superimposed pruritic inflammation which reacts positively to the treatment.…”

Section: Discussionmentioning

confidence: 99%

Does Inflammatory Linear Verrucous Epidermal Nevus Represent a Segmental Type 1/Type 2 Mosaic of Psoriasis?

Hofer¹

2006

Dermatology

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Background: A 6-year-old girl with a symmetric linear eruption on both of her legs, clinically and histologically resembling inflammatory linear verrucous epidermal nevus (ILVEN) or linear psoriasis (LP), with concomitant psoriasis of the guttata type and a positive family history of psoriasis is presented. The questions as to whether LP actually exists and ILVEN represents a distinct entity are still under debate. Objective and Methods: The recent literature concerning case reports of ILVEN and LP is reviewed. Results: Case reports of ILVEN and LP can be subdivided into four different groups: (1) ILVEN with or without concomitant psoriasis, only in part reacting to antipsoriatic treatment, (2) ILVEN without concomitant psoriasis, (3) LP with concomitant psoriasis vulgaris, with both groups 2 and 3 reacting successfully to antipsoriatic treatment, and (4) LP without concomitant psoriasis vulgaris and with no family history of psoriasis (very rarely reported). Conclusion: It is hypothesized that inflammatory linear verrucous eruption besides nevoid psoriasis/LP represents a further segmental type 1/type 2 mosaic of psoriasis which, if a (verrucous) epidermal nevus exists, shows a high affinity of occurrence in close context to such a nevus. Heritability is thought to be possible.

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“…[67] The lesions consisted of pruritic, erythematous, hyperkeratotic, linear plaques, distributed unilaterally with greater involvement of the left side. [4689]…”

Section: Discussionmentioning

confidence: 99%

“…[89] Also, it can be initiated in adulthood. [10] It is more common in females (male to female ratio is 1:4)[56] and may be familial in some cases.…”

Section: Discussionmentioning

confidence: 99%

Epidermolytic hyperkeratosis in inflammatory linear verrucous epidermal nevus

2011

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Epidermolytic hyperkeratosis presents with perinuclear vacuolization of the keratinocytes in spinous and granular layers, keratinocytes with ill-defined limits, which leads to a reticulate appearance of the epidermis, an increased number of variously shaped and sized basophilic keratohyalin granules and the same sized eosinophilic trichohyalin granules, at any level of epidermis, mainly in the stratum granulosum, and compact hyperkeratosis. This minor reactive pathologic reaction pattern of skin is found in large variety of diseases. This paper is the first case report of such pattern in inflammatory linear verrucous epidermal nevus. Our case is of a 23-year-old man with pruritic verrucous lesions of trunk and extremities initiated since 13 years ago. Physical examination revealed white linear hyperkeratotic lesions, some of them on erythematous background and also classic epidermal nevus. No skeletal, ophthalmic, and nervous system involvement was detected. Microscopic study of pruritic verrucous lesions showed psoriasiform acanthosis, mild papillomatous, hyperkeratosis, and epidermolytic hyperkeratotic changes in hair follicles and acrosyrinx accompanied with moderate perivascular inflammation.

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Inflammatory linear verrucous epidermal nevus and arthritis: A new association

Cited by 19 publications

References 13 publications

Vulvar and Perianal Condyloma Superimposed Inflammatory Linear Verrucous Epidermal Nevus: A Case Report and Review of the Literature

Vulvar and Perianal Condyloma Superimposed Inflammatory Linear Verrucous Epidermal Nevus: A Case Report and Review of the Literature

Does Inflammatory Linear Verrucous Epidermal Nevus Represent a Segmental Type 1/Type 2 Mosaic of Psoriasis?

Epidermolytic hyperkeratosis in inflammatory linear verrucous epidermal nevus

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