Inflammatory Markers and Disease Activity in Juvenile Idiopathic Arthritis

Sarkar, Sumantra; Alam, Md. Mahboob; Das, Gargi; Datta, Supratim

doi:10.1007/s12098-017-2292-6

Cited by 14 publications

(16 citation statements)

References 16 publications

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“…The analysis of the ESR demonstrates the disease activity both at onset and follow-up of the subjects with JIA. In a similar manner, CRP is also an inflammatory parameter, as an acute phase protein [29]. During active disease, high ESR and CRP values relate to immunologic response; particularly innate immun phase.…”

Section: Discussionmentioning

confidence: 92%

Evaluation of the Serum Visfatin and Adiponectin Levels Related with the Activity of Juvenile Idiopathic Arthritis

Çalışkan¹,

Güngör²,

Ekmekçi³

et al. 2021

jarem

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Objective: Our aim was to investigate the possible relationship of serum adiponectin and visfatin levels that are derived from the adipose tissue, with the activity of juvenile idiopathic arthritis (JIA) in accordance with the routinely used biochemical parameters, to evaluate the management of the therapy and the assessment of the disease activity.Methods: Dependent on the Wallace criteria; the study group is composed of active, remission and control subjects. Serum adiponectin and visfatin levels were measured by the enzyme-linked immunosorbent assay method. Complete blood count, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were routinely measured. Neutrophil/lymphocyte ratio (NLR) was calculated.Results: There were statistically significant differences in serum visfatin levels among the active and the control groups (p<0,05) whereas; a statistically signifficant difference was found in serum adiponectin levels between the active and the remission groups (p<0,05). Significant differences were also observed in routinely used parameters; ESR, CRP and platelet counts (p<0,05) among the active, remission and control subjects, whereas the leukocyte and neutrophil counts together with the percentage of neutrophils, lymphocytes and NLR established significant differences only between the active and control groups (p<0.05) Conclusion:We can assume that serum visfatin levels may be useful to indicate the activity of the disease in accordance with the correlation between ESR and CRP in JIA subjects. Unlike visfatin; serum adiponectin levels may be utilized at the management of the therapy rather than the diagnostic parameter on the onset of JIA. Although the present study has been designed within the limited JIA subjects, this research highlights these two adipose tissue derived paramaters as new biochemical parameters in JIA subjects, both in the assessment of the disease activity and management of the therapy, that are essential for the life quality of these patients.

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Section: Discussionmentioning

confidence: 92%

Evaluation of the Serum Visfatin and Adiponectin Levels Related with the Activity of Juvenile Idiopathic Arthritis

Çalışkan¹,

Güngör²,

Ekmekçi³

et al. 2021

jarem

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“…Increased levels of these inflammatory cytokines have also been reported in JIA 35 . Measurement of inflammatory activity in JIA is more accurate with JADAS27, 24 and this is probably why we did in fact identify an association based on this instrument but not on the DAS28.…”

Section: Discussionmentioning

confidence: 65%

“…Additional data recorded for patients with JIA included the date of onset of the disease, duration of the disease (time from diagnosis to the cut‐off), diagnostic delay (months between onset of symptoms and diagnosis of JIA), uveitis, and the following laboratory data: rheumatoid factor (RF), positive if >20 IU/mL; anticitrullinated peptide antibodies (ACPA), positive if >10 IU/mL; positive human leukocyte antigen‐B27 titer; and positive antinuclear antibody (ANA) titer at any point during the disease. Disease activity was assessed cross‐sectionally using the following: Disease Activity Score of 28 joints – erythrocyte sedimentation rate (DAS28‐ESR) 23 ; Juvenile Arthritis Disease Activity Score (JADAS27) (based on a 27‐joint count) 24 ; and physical function by means of the Health Assessment Questionnaire (HAQ) 25 . We recorded all current medication, synthetic disease‐modifying antirheumatic drugs (DMARDs), (methotrexate, leflunomide, and sulfasalazine), biologic DMARDs (anti‐TNF inhibitors, tocilizumab, abatacept, rituximab, and ustekinumab), and Janus‐activated kinase inhibitors (tofacitinib and baricitinib).…”

Section: Methodsmentioning

confidence: 99%

“…According to the scoring system, depression can be classified as minimal (0-13), mild (14)(15)(16)(17)(18)(19), moderate (20)(21)(22)(23)(24)(25)(26)(27)(28), and severe . It has proven useful for identifying depression in various medical specialties, including rheumatology.…”

Section: Bdi-iimentioning

confidence: 99%

“…Disease Activity Score of 28 joints -erythrocyte sedimentation rate (DAS28-ESR) 23 ; Juvenile Arthritis Disease Activity Score (JADAS27) (based on a 27-joint count) 24 ; and physical function by means of the Health Assessment Questionnaire (HAQ). 25 We recorded all current medication, synthetic disease-modifying antirheumatic drugs (DMARDs), (methotrexate, leflunomide, and sulfasalazine), biologic DMARDs (anti-TNF inhibitors, tocilizumab, abatacept, rituximab, and ustekinumab), and Janus-activated kinase inhibitors (tofacitinib and baricitinib).…”

Section: Operational Definitions and Variablesmentioning

confidence: 99%

See 2 more Smart Citations

Evaluation of cognitive function in adult patients with juvenile idiopathic arthritis

et al. 2020

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Objective: To evaluate cognitive function in adult patients with juvenile idiopathic arthritis (JIA) and associated factors. Patients and methods: We performed a cross-sectional observational study of adult patients with JIA and a healthy control group (no inflammatory diseases) matched for age, gender, and educational level. Cognitive function was assessed using Wechsler Adult Intelligence Scale-III. The cognitive domains measured were attention/concentration, verbal function, visuospatial organization, working memory, and problem solving (Similarities). Other measures included clinical-epidemiological characteristics, comorbid conditions, and treatment. We performed a descriptive bivariate analysis and logistic regression to identify factors associated with visuospatial involvement. Results: The study population comprised 104 subjects (52 with JIA and 52 healthy controls). Patients with JIA had poorer results for visuospatial function, with a lower median scaled score on the Block Design test (5.

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Uric acid could be a marker of cardiometabolic risk and disease severity in children with juvenile idiopathic arthritis

et al. 2022

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Inflammatory Markers and Disease Activity in Juvenile Idiopathic Arthritis

Abstract: Inflammatory markers and disease activity decreased in all subtypes of JIA with treatment without biologics. Acute phase markers often remain elevated in inactive disease state. Similarly, normal level of an inflammatory marker does not necessarily indicate absence of active disease.

Cited by 14 publications

References 16 publications

Evaluation of the Serum Visfatin and Adiponectin Levels Related with the Activity of Juvenile Idiopathic Arthritis

Evaluation of the Serum Visfatin and Adiponectin Levels Related with the Activity of Juvenile Idiopathic Arthritis

Evaluation of cognitive function in adult patients with juvenile idiopathic arthritis

Uric acid could be a marker of cardiometabolic risk and disease severity in children with juvenile idiopathic arthritis

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