Inflammatory markers in clinical practice

Sotak, Štefan

doi:10.36290/vnl.2022.100

Cited by 4 publications

(2 citation statements)

References 11 publications

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“…Metabolic abnormalities are significantly higher in BD compared to the general population and have been linked to unfavorable illness trajectories 15 . Specifically, laboratory markers indicate elevated serum triglycerides and glycosylated hemoglobin, hyperinsulinemia, insulin resistance, and lowered HDL, compared with healthy controls 84 . These increased blood markers of metabolic syndrome have been associated with decreased treatment efficacy and worsened disease course in BD 85 .…”

Section: Bd As An Illness Of Metabolic Let Lagmentioning

confidence: 99%

“…15 Specifically, laboratory markers indicate elevated serum triglycerides and glycosylated hemoglobin, hyperinsulinemia, insulin resistance, and lowered HDL, compared with healthy controls. 84 These increased blood markers of metabolic syndrome have been associated with decreased treatment efficacy and worsened disease course in BD. 85 Individuals with BD also demonstrate a greater prevalence of obesity when compared with the general population.…”

Section: Bd As An Illness Of Metabolic Let Lagmentioning

confidence: 99%

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The concept of “metabolic jet lag” in the pathophysiology of bipolar disorder: implications for research and clinical care

et al. 2022

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Bipolar disorder (BD) is a potentially chronic mental disorder marked by recurrent depressive and manic episodes, circadian rhythm disruption, and changes in energetic metabolism. “Metabolic jet lag” refers to a state of shift in circadian patterns of energy homeostasis, affecting neuroendocrine, immune, and adipose tissue function, expressed through behavioral changes such as irregularities in sleep and appetite. Risk factors include genetic variation, mitochondrial dysfunction, lifestyle factors, poor gut microbiome health and abnormalities in hunger, satiety, and hedonistic function. Evidence suggests metabolic jet lag is a core component of BD pathophysiology, as individuals with BD frequently exhibit irregular eating rhythms and circadian desynchronization of their energetic metabolism, which is associated with unfavorable clinical outcomes. Although current diagnostic criteria lack any assessment of eating rhythms, technological advancements including mobile phone applications and ecological momentary assessment allow for the reliable tracking of biological rhythms. Overall, methodological refinement of metabolic jet lag assessment will increase knowledge in this field and stimulate the development of interventions targeting metabolic rhythms, such as time-restricted eating.

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Section: Bd As An Illness Of Metabolic Let Lagmentioning

confidence: 99%

Section: Bd As An Illness Of Metabolic Let Lagmentioning

confidence: 99%

The concept of “metabolic jet lag” in the pathophysiology of bipolar disorder: implications for research and clinical care

et al. 2022

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Parenteral nutrition customization in pediatrics: A descriptive cohort study

Pinho,

Freitas,

Nogueira

2024

J Parenter Enteral Nutr

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ObjectivesThe main objective of this study was to analyze the reasons for customizing parenteral nutrition (PN) in pediatric patients admitted to a quaternary hospital.MethodsWe performed a descriptive cohort study on 264 hospitalized children receiving PN. Anthropometric, biochemical, and hospitalization data were collected from patient records. Unequivocal reasons for customizing PN were defined as situations precluding prescription of a standard adult/teenager PN and included renal and/or liver failure, energy‐protein adequacy, and elevated mineral and triglyceride levels.ResultsA total of 264 patients, with a median age of 2.2 years (IQR: 0.3–9.0 years), comprising intensive care (n = 216; 81.8%) and malnourished (n = 91; 36.1%) patients, were evaluated. In the first 48 h, 87.9% (n = 232) of the sample required customized PN for energy‐protein adequacy (210 of 232), maintained over subsequent days in most cases. Among patients requiring second individualization, mineral disturbance was the main reason observed, especially within the first 4 days of PN use (n = 21; 60%). Unequivocal reasons for customizing PN occurred in 97.4% (n = 226) of cases in the first 48 h; 96.2% (n = 177) of cases on the fourth day; and 90.1% (n = 92) of cases on the seventh day of PN use. An inverse correlation was found between weight/age z score and number of second individualizations (r = −0.222; P = 0.002).ConclusionCustomized PN proved essential, especially for younger, malnourished, and intensive care patients. Investment in training a Nutritional Multidisciplinary Therapy Team and acquiring a specific electronic system for prescribing PN is suggested.

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Cardiovascular autonomic dysfunction in “Long COVID”: pathophysiology, heart rate variability, and inflammatory markers

Marques,

Quaresma,

Falcão

2023

Front. Cardiovasc. Med.

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Long COVID is characterized by persistent signs and symptoms that continue or develop for more than 4 weeks after acute COVID-19 infection. Patients with Long COVID experience a cardiovascular autonomic imbalance known as dysautonomia. However, the underlying autonomic pathophysiological mechanisms behind this remain unclear. Current hypotheses include neurotropism, cytokine storms, and inflammatory persistence. Certain immunological factors indicate autoimmune dysfunction, which can be used to identify patients at a higher risk of Long COVID. Heart rate variability can indicate autonomic imbalances in individuals suffering from Long COVID, and measurement is a non-invasive and low-cost method for assessing cardiovascular autonomic modulation. Additionally, biochemical inflammatory markers are used for diagnosing and monitoring Long COVID. These inflammatory markers can be used to improve the understanding of the mechanisms driving the inflammatory response and its effects on the sympathetic and parasympathetic pathways of the autonomic nervous system. Autonomic imbalances in patients with Long COVID may result in lower heart rate variability, impaired vagal activity, and substantial sympathovagal imbalance. New research on this subject must be encouraged to enhance the understanding of the long-term risks that cardiovascular autonomic imbalances can cause in individuals with Long COVID.

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Inflammatory markers in clinical practice

Cited by 4 publications

References 11 publications

The concept of “metabolic jet lag” in the pathophysiology of bipolar disorder: implications for research and clinical care

The concept of “metabolic jet lag” in the pathophysiology of bipolar disorder: implications for research and clinical care

Parenteral nutrition customization in pediatrics: A descriptive cohort study

Cardiovascular autonomic dysfunction in “Long COVID”: pathophysiology, heart rate variability, and inflammatory markers

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