Inflammatory markers in younger vs elderly normal volunteers and in patients with Alzheimer’s disease

Maes, Michaël; Devos, Nathalie; Wauters, Annick; Demedts, Paul; Maurits, Vande Woude; Neels, Hugo; Bosmans, Eugène; Altamura, Carlo; Lin, Aihua; Song, Cai; Vandenbroucke, Michel; Scharpé, Simon

doi:10.1016/s0022-3956(99)00016-3

Cited by 105 publications

(70 citation statements)

References 58 publications

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“…The current findings are consistent with a number of case control studies linking low levels of serum albumin with cognitive impairment [6,7] and dementia [5,8] However, results from previous population-based studies have been equivocal. Our results are similar to the linear association between serum albumin levels and MMSE performance in community-living older Chinese adults recently observed by Ng and colleagues.…”

Section: Discussionsupporting

confidence: 90%

“…[1,2] Critical to translating new therapies into improved patient care is the development of costeffective panels of biomeasures that complement cognitive testing, clinical examination, and neuroimaging. Serum albumin is of interest as it is the most abundant protein in human plasma, a marker of liver function, a negative acute-phase marker, and a key antioxidant [3][4][5] Findings from highly selected clinical samples suggest serum albumin concentration may be associated with cognitive impairment and dementia. For example, low levels of serum albumin were found to be associated with an increased risk of cognitive impairment in 1,511 hospitalized patients with heart failure, [6] and 331 elderly rehabilitation patients with hip fractures.…”

Section: Introductionmentioning

confidence: 99%

“…For example, low levels of serum albumin were found to be associated with an increased risk of cognitive impairment in 1,511 hospitalized patients with heart failure, [6] and 331 elderly rehabilitation patients with hip fractures. [7] Lower levels of serum albumin have also been observed in Alzheimer's disease (AD) patients in comparison with healthy volunteer controls in some, [5,8] but not all small clinical studies [9]. However, results from large representative population-based studies are limited and equivocal, and the external validity of previous clinical results is largely unknown.…”

Section: Introductionmentioning

confidence: 99%

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Serum Albumin Concentration and Cognitive Impairment

Llewellyn¹

2009

CAR

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Results from clinical samples suggest low serum albumin may be associated with cognitive impairment, though evidence from population-based studies is inconclusive. Participants were 1,752 adults (699 men and 1,053 women) aged 65 years and over from the Health Survey for England 2000, a nationally representative population-based study. Cognitive impairment was assessed using the Abbreviated Mental Test Score. The cross-sectional relation of serum albumin quartiles to cognitive impairment was modelled using logistic regression. Two hundred and twelve participants were cognitively impaired (68 men and 144 women). Odds ratios (95% confidence intervals) for cognitive impairment in the first (2.2-3.8 g/dl), second (3.9-4.0 g/dl), and third (4.1-4.3 g/dl) quartiles of serum albumin compared with the fourth (4.4-5.3 g/dl) were 2.5 (1.3-5.1), 1.7 (0.9-3.5), and 1.5 (0.7-2.9), after adjustment for age, sex, education and additional risk factors for cognitive impairment (p for linear trend = 0.002). A highly similar pattern of associations was observed for men and women. Our data provide new evidence to suggest that low serum albumin is independently associated with increased odds of cognitive impairment in the elderly population.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Serum Albumin Concentration and Cognitive Impairment

Llewellyn¹

2009

CAR

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“…Serum zinc levels tend to decline with advancing age (Maes et al, 1999;Seiler, 1999). Zinc is a trace element contained mostly in foods of animal origin and, to a lesser degree, in cereals and dairy products.…”

Section: Introductionmentioning

confidence: 99%

Zinc status and taste acuity in older Europeans: the ZENITH study

Stewart-Knox

Simpson²,

Parr

et al. 2005

Eur J Clin Nutr

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Background: Age-related decline in taste acuity may be both a cause and an effect of depleted zinc and/or increased zinc requirement. Objective: The aim of this study was to explore associations between zinc status and taste acuity in healthy older European adults aged 55-90 y. Sample: Volunteers were recruited within Italy (n ¼ 108 aged 70-90 y), the United Kingdom (UK) (n ¼ 93 aged 55-70) and two regions of France (n ¼ 186), Grenoble (aged 70-90 y) and Clermont-Ferrand (aged 55-70 y). Methods: A signal detection theory approach was adopted, employing a three-alternative, forced-choice procedure. The data were converted to R-indices and bivariate correlations were computed to explore relationships between serum zinc, erythrocyte zinc and taste acuity. ANOVA was undertaken to determine regional differences in zinc status. Results: Higher erythrocyte zinc status was associated with better acuity for salt (sodium chloride) taste in the sample as a whole (P ¼ 0.012) (n ¼ 385). Higher serum zinc levels were associated with greater sensitivity to sour taste (citric acid) (P ¼ 0.015) only in the older groups (aged 70-90 y). There were no apparent associations between serum or erythrocyte zinc status and acuity for bitter (quinine) or sweet (sucrose) tastes irrespective of age. Conclusion: These results agree with those previously suggesting that age-related detriment in sensitivity for salt taste may be associated with depleted zinc.

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“…The expression of IFN␥ and target CD8 ϩ T cells is enhanced as a function of age and neurodegeneration. 3,4 Moreover, IFN␥ enhances vascular permeability to T cells and natural killer cells and promotes the expression of TNF-␣ and IL-1␤ by microglia (reviewed in Ref. 5 ), suggesting that IFN␥ is a key player in the elaboration of immune and inflammatory responses within the CNS and is involved in neurodegeneration.…”

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confidence: 99%

Interferon-γ Differentially Affects Alzheimer’s Disease Pathologies and Induces Neurogenesis in Triple Transgenic-AD Mice

Mastrangelo

Sudol

Narrow

et al. 2009

The American Journal of Pathology

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Inflammatory processes, including the episodic and/ or chronic elaboration of cytokines , have been identified as playing key roles in a number of neurological disorders. Whether these activities impart a disease-resolving and/or contributory outcome depends at least in part on the disease context, stage of pathogenesis, and cellular milieu in which these factors are released. Interferon-␥ (IFN␥) is one such cytokine that produces pleiotropic effects in the brain. It is protective by ensuring maintenance of virus latency after infection, yet deleterious by recruiting and activating microglia that secrete potentially damaging factors at sites of brain injury. Using the triple-transgenic mouse model of Alzheimer's disease (3؋Tg-AD), which develops amyloid and tau pathologies in a pattern reminiscent of human Alzheimer's disease, we initiated chronic intrahippocampal expression of IFN␥ through delivery of a serotype-1 recombinant adeno-associated virus vector (rAAV1-IFN␥). Ten months of IFN␥ expression led to an increase in microglial activation, steady-state levels of proinflammatory cytokine and chemokine transcripts, and severity of amyloid-related pathology. In contrast, these rAAV1-IFN␥-treated 3؋Tg-AD mice also exhibited diminished phospho-tau pathology and evidence of increased neurogenesis. Overall, IFN␥ mediates what seem to be diametrically opposed functions in the setting of AD-related neurodegeneration. Gaining an understanding as to how these apparently divergent functions are interrelated and controlled could elucidate new therapeutic strategies designed to harness the neuroprotective activity of IFN␥. (Am J Pathol

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Inflammatory markers in younger vs elderly normal volunteers and in patients with Alzheimer’s disease

Cited by 105 publications

References 58 publications

Serum Albumin Concentration and Cognitive Impairment

Serum Albumin Concentration and Cognitive Impairment

Zinc status and taste acuity in older Europeans: the ZENITH study

Interferon-γ Differentially Affects Alzheimer’s Disease Pathologies and Induces Neurogenesis in Triple Transgenic-AD Mice

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