Inflammatory Mediators Gene Polymorphisms in Preeclampsia

Franchim, Camila Sommerauer; Sass, Nelson; Mattar, Rosiane; Pendeloski, Karen Priscilla Tezotto; Lin, Lawrence Hsu; Torloni, Maria Regina; Daher, Sílvia

doi:10.3109/10641950903455389

Cited by 18 publications

(16 citation statements)

References 49 publications

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“…In opposition to our results, the C allele was associated with higher risk of a wide range of diseases of immune dysregulation, including psoriasis, ankylosing spondylitis , nasopharyngeal , cervical and oesophageal cancers . However, no association was found between this variant and Chronic obstructive pulmonary disease (COPD) , pulmonary tuberculosis , Type I Diabetes, Acute coronary syndrome (ACS), pre‐eclampsia , psoriasis and IBD .…”

Section: Discussioncontrasting

confidence: 99%

Levels of Interleukin‐(IL)‐12p40 are Markedly Increased in Brucellosis Among Patients with Specific IL‐12B Genotypes

et al. 2013

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Brucellosis remains a major zoonosis worldwide. Brucella antigens induce the production of T-helper 1 (Th1) cytokines such as interleukin-12 (IL-12) in humans. We aimed to investigate the association of two single nucleotide polymorphisms (SNPs) in the gene encoding the IL-12p40 cytokine (IL-12B) with brucellosis and to examine the functionality of these SNPs through measuring serum levels of IL-12p40. We genotyped IL-12B gene rs3212227, A>C; rs6887695 G>C polymorphisms in a case-control study on a total of 281 subjects including 153 patients with active brucellosis and 128 healthy controls, using RFLP and serum IL-12p40 levels, were assessed by ELISA. The rs3212227 minor allele (C) and homozygote genotype (CC) were more frequent in controls compared with patients with brucellosis (P = 0.006, OR = 0.608, 95%CI = 0.429-0.861 for the C allele; P = 0.024, OR = 0.443, 95% CI: 0.218-0.900 for the CC genotype). Comparison of IL-12B genotypes and serum levels of the IL-12p40 revealed that rs3212227 AA genotype, with higher frequency in patients than in controls, was associated with increased levels of the cytokine (P = 0.0001). Furthermore, the distribution of haplotype and genotype combinations in our study suggested that rs3212227C/rs6887695C haplotype or CC/GC or CC/CC genotype combinations may protect controls against Brucella infection by contributing to a functional downregulation of the serum IL-12p40 production in vivo, as shown by ELISA (P < 0.05). Overall, our study demonstrated that rs3212227 A variant was associated with higher levels of serum IL-12p40 and could possibly contribute to an inherited predisposition to brucellosis.

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Section: Discussioncontrasting

confidence: 99%

Levels of Interleukin‐(IL)‐12p40 are Markedly Increased in Brucellosis Among Patients with Specific IL‐12B Genotypes

et al. 2013

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“…This study used relatively large samples, which indicated a low false negative rate; therefore, our results suggest that variants in this genomic region are not associated with preeclampsia. Similar to this conclusion, TLR2 and TLR4 have also been reported to have no association with PE, even though they may play an important role in placental development [28,29]. rs3775291, located in the protein-coding sequence, results in an amino acid substitution, which may reduce or abolish TLR3 activity [17].…”

Section: Discussionsupporting

confidence: 57%

Role of Toll-Like Receptor 3 Gene Polymorphisms in Preeclampsia

Chen

Wang

et al. 2015

Cell Physiol Biochem

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Background/Aims: Accumulating evidence suggests that an excessive maternal systemic inflammatory response to pregnancy with exaggerated activation of the innate immune system plays a critical role in the development of preeclampsia (PE). In this study, we investigated whether polymorphisms in the Toll-like receptor 3 (TLR3) gene are associated with susceptibility to PE in the Chinese Han population. Methods: We recruited 987 PE patients and 1227 healthy pregnant women. Two polymorphisms (rs3775291 and rs3775296) located in TLR3 were genotyped by TaqMan allelic discrimination real-time PCR. The association between the genotype or allele frequencies and PE was examined using chi-square tests. Clinical data were compared between cases and controls using Student's t test. Results: No significant difference was determined in the genetic distribution of rs3775291 and rs3775296 between cases and controls. There were also no significant differences in the genotype and allele frequencies of either SNP between healthy pregnant women and patients with late or early onset PE, or with mild or severe PE. Conclusion: Although this is the first study of the association between TLR3 polymorphisms and preeclampsia, we found that TLR3 polymorphisms are unlikely to play a significant role in the development of preeclampsia in the Chinese Han population.

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“…Chen et al studied the role of polymorphism in the 3′‐untranslated region of IL‐1α gene and suggested the protective effect of “TTCA” insertion allele (OR: 0.487, 95% CI: [0.360‐0.658]) . In contrast, no association was found between a polymorphism in the IL‐1 receptor type 1 (IL‐1R1) gene and the disease . Similarly, Hefler et al proposed that polymorphisms of IL‐1R, although not significantly different among the studied groups, were correlated with higher systolic blood pressure and liver function tests in PE women.…”

Section: Resultsmentioning

confidence: 99%

“…The hypothesis that the IL‐12B rs3212227 SNP, a 3’‐untranslated region SNP associated with a variety of autoimmune diseases, for example, type 1 diabetes mellitus, may predispose to PE was tested in a 2011 case‐control study in 283 Brazilian women: No significant relationship was found ( P = 0.93) . To further support this finding, the effect of IL‐12B rs3212227 SNP in PE development in women of Chinese Han descent was estimated in a case‐control study of 1000 PE, further divided into mild and severe PE and early‐ and late‐onset PE, and 1287 normotensive controls: No difference was found between any of the PE groups and the control group nor was an association of the SNP with severity of PE established …”

Section: Resultsmentioning

confidence: 99%

The role of interleukins in preeclampsia: A comprehensive review

Bellos

Karageorgiou

Kapnias

et al. 2018

American J Rep Immunol

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Preeclampsia is a multi‐system hypertensive disorder of pregnancy, with significant rates of maternal and neonatal morbidity. It represents a major cause of preterm birth, as definitive treatment demands fetal delivery. Although its pathophysiology is complicated, placental hypoxia and endothelial dysfunction constitute established pathogenetic steps of the disease. Inflammation is considered to be a crucial mediator of preeclampsia process, as an imbalance between TH1, TH2, and TH17 immune responses is observed. The present review accumulates current knowledge about the contribution of interleukins in preeclampsia, summarizing the pathways through which each interleukin exerts its function in the disease. Also, the role of genetic polymorphisms is explored and the predictive efficacy of maternal serum interleukin levels is evaluated. Finally, recommendations about the safe interpretation of the outcomes, as well as guidance for future research, are provided.

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Inflammatory Mediators Gene Polymorphisms in Preeclampsia

Abstract: The analyzed gene polymorphisms are not associated with PE.

Cited by 18 publications

References 49 publications

Levels of Interleukin‐(IL)‐12p40 are Markedly Increased in Brucellosis Among Patients with Specific IL‐12B Genotypes

Levels of Interleukin‐(IL)‐12p40 are Markedly Increased in Brucellosis Among Patients with Specific IL‐12B Genotypes

Role of Toll-Like Receptor 3 Gene Polymorphisms in Preeclampsia

The role of interleukins in preeclampsia: A comprehensive review

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