Inflammatory mediators, oxidative stress and genetic disturbance in rheumatoid arthritis rats supported by alfalfa seeds metabolomic constituents <i>via</i> blocking interleukin‐1receptor.

Aboul Naser, Asmaa F.; Ahmed, Yomna R.; Mohammed, Mona A.; Aboelmagd, Mohamed; Aboutabl, Mona E.; Hassan, Entesar E.; Khalil, Wagdy K. B.; Hamed, Manal A.

doi:10.1002/cbdv.202301653

Cited by 2 publications

(1 citation statement)

References 76 publications

(129 reference statements)

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“…Alfalfa seeds are not only the key to alfalfa breeding, but research has shown that the components of alfalfa seeds are complex, and the butanol component has a therapeutic effect on rheumatoid arthritis [15]. In addition, alfalfa seeds contain a variety of nutrients and medicinal ingredients.…”

Section: Introductionmentioning

confidence: 99%

Analysis and Identification of Differences in Volatile Components of Various Alfalfa Seeds Based on GC-IMS

Zhao,

Zhu,

Yang

et al. 2024

Agronomy

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Volatile components are one key factor in sample identification, differential analysis, quality control and origin traceability. In order to identify and analyze the differences in volatile substances in different alfalfa seeds, this study used gas chromatography–ion mobility spectrometry (GC-IMS), combined with the Gallery Plot plug-in, and PCA, PLS-DA and other analysis methods. In this way, a comprehensive analysis of volatile components in 10 alfalfa seeds, including aerospace varieties, was conducted. A comparative analysis of the characteristics of different sample compounds using topographic maps and fingerprints led to isolation of 48 kinds of 54 volatile compounds. Among them, esters (9 types), olefins (8 types), ketones (8 types), alcohols (6 types) and aldehydes (6 types) were found to be the most abundant volatile compounds in alfalfa seeds. At the same time, PCA and PLS-DA analysis models showed that esters, ketones and alcohols were the main volatiles causing the differences among alfalfa seeds. Among them, the content of various substances in the ZT2 and ZT3 aerospace varieties were higher than that of other varieties, while the types and contents of volatiles in ZT1, ZM2 and GN3 were relatively low. Therefore, in combination with the differences in maturity of each sample, the 10 varieties of alfalfa were finally divided into three categories, and the varieties of the same series were basically classified into one category. This provides a basis and convenience for future seed screening, identification, traceability and forage breeding.

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Section: Introductionmentioning

confidence: 99%

Analysis and Identification of Differences in Volatile Components of Various Alfalfa Seeds Based on GC-IMS

Zhao,

Zhu,

Yang

et al. 2024

Agronomy

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GC/MS and LC‐ESI‐MS Analysis of Conocarpus erectus Leaves Extract via Regulating Amyloid‐β‐Peptide, Tau Protein, Neurotransmitters, Inflammation and Oxidative Stress against AlCl₃‐Induced Alzheimer's Disease in Rats

Nasr,

El‐Hagrassi,

Ahmed

et al. 2024

Chemistry & Biodiversity

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This study investigated the therapeutic effect of Conocarpus erectus leaves methanolic extract against AlCl3 ‐induced Alzheimer’s disease (AD) in rats comparing with Donepezil‐hydrochloride as a reference drug. The bioactive compounds of C. erectus leaves were isolated and identified by GC/MS and LC‐ESI‐MS analysis. Malondialdehyde (MDA), reduced glutathione (GSH), superoxide dismutase (SOD), tumor necrosis factor‐alpha (TNF‐α), interleukin‐6 (IL‐6), amyloid‐β‐peptide (Aβ‐peptide), tau protein, acetylcholinesterase (AChE), serotonin (5‐HT), dopamine (DA) and nor‐adrenaline (NE) levels were estimated. The neuromuscular strength, memory behavior and histopathological examination of cerebral cortex region were also conducted. Forty‐three compounds were characterized from the non‐polar fraction of C. erectus L. leaves extract and nineteen compounds were identified from the defatted extract. AlCl3‐ induction caused significant elevation of brain oxidative stress, Aβ‐peptide, tau protein, IL‐6, TNF‐α and AChE levels. A significant decrease in 5‐HT, ND and DA levels were noticed. Additionally, AlCl3 reduced neuromuscular strength and compromised memory function. Treatment of AlCl3‐ induced rats with C. erectuse extract ameliorated these selected parameters by variable degrees. In conclusion, C. erectus protects against AlCl3‐ induced AD in rats through its antioxidant, anti‐inflammatory, and antineutron damage. It could be considered as a new nutraceutical agent for attenuating symptoms associated with Alzheimer's disease.

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Inflammatory mediators, oxidative stress and genetic disturbance in rheumatoid arthritis rats supported by alfalfa seeds metabolomic constituents via blocking interleukin‐1receptor.

Cited by 2 publications

References 76 publications

Analysis and Identification of Differences in Volatile Components of Various Alfalfa Seeds Based on GC-IMS

Analysis and Identification of Differences in Volatile Components of Various Alfalfa Seeds Based on GC-IMS

GC/MS and LC‐ESI‐MS Analysis of Conocarpus erectus Leaves Extract via Regulating Amyloid‐β‐Peptide, Tau Protein, Neurotransmitters, Inflammation and Oxidative Stress against AlCl₃‐Induced Alzheimer's Disease in Rats

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Inflammatory mediators, oxidative stress and genetic disturbance in rheumatoid arthritis rats supported by alfalfa seeds metabolomic constituents via blocking interleukin‐1receptor.

Cited by 2 publications

References 76 publications

Analysis and Identification of Differences in Volatile Components of Various Alfalfa Seeds Based on GC-IMS

Analysis and Identification of Differences in Volatile Components of Various Alfalfa Seeds Based on GC-IMS

GC/MS and LC‐ESI‐MS Analysis of Conocarpus erectus Leaves Extract via Regulating Amyloid‐β‐Peptide, Tau Protein, Neurotransmitters, Inflammation and Oxidative Stress against AlCl3‐Induced Alzheimer's Disease in Rats

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GC/MS and LC‐ESI‐MS Analysis of Conocarpus erectus Leaves Extract via Regulating Amyloid‐β‐Peptide, Tau Protein, Neurotransmitters, Inflammation and Oxidative Stress against AlCl₃‐Induced Alzheimer's Disease in Rats