2007
DOI: 10.1080/17453670710014329
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Inflammatory response in 85 patients with loosened hip prostheses: A prospective study comparing inflammatory markers in patients with aseptic and septic prosthetic loosening

Abstract: Background The most common complications of prosthetic hip joints are aseptic mechanical failure and infection. Delayed low-grade infections are seen most often, and they are also most difficult to distinguish from aseptic mechanical failures.Methods We conducted a prospective study to compare inflammatory markers in patients diagnosed with aseptic or septic prosthetic loosening. The diagnostic criteria were based on the decisions of experienced orthopedic surgeons and microbiological analysis of periprostheti… Show more

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Cited by 75 publications
(53 citation statements)
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“…Gollwitzer et al [9] evaluated 10 markers in their ability to specifically distinguish aseptic loosening from staphylococcal infections, and IL-1b had a sensitivity of 0.67, whereas IL-6 had a sensitivity of 0.6. Nilsdotter-Augustinsson et al [12] attempted to differentiate septic from aseptic loosening with the use of 11 inflammatory markers; IL-1b and IL-6 had sensitivities of 0.59 and 0.69, respectively. Despite the promising clinical applicability that synovial fluid cytokines may provide for the diagnosis of PJI, there is still a lack of large multiinstitutional studies to validate this method.…”
Section: Discussionmentioning
confidence: 99%
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“…Gollwitzer et al [9] evaluated 10 markers in their ability to specifically distinguish aseptic loosening from staphylococcal infections, and IL-1b had a sensitivity of 0.67, whereas IL-6 had a sensitivity of 0.6. Nilsdotter-Augustinsson et al [12] attempted to differentiate septic from aseptic loosening with the use of 11 inflammatory markers; IL-1b and IL-6 had sensitivities of 0.59 and 0.69, respectively. Despite the promising clinical applicability that synovial fluid cytokines may provide for the diagnosis of PJI, there is still a lack of large multiinstitutional studies to validate this method.…”
Section: Discussionmentioning
confidence: 99%
“…The four synovial fluid biomarkers with the highest patient numbers evaluated for this purpose were CRP [5,6,13,15,16,18,20,21], IL-6 [4,6,[9][10][11][12]19], adefensin [1,5,6], and IL-1b [4,6,9,12], respectively. Although a-defensin clearly shows the highest diagnostic accuracy, it has only been evaluated in three studies to the date of our review, two of which emanate from the same group of researchers.…”
Section: Discussionmentioning
confidence: 99%
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“…Serum ESR and CRP are useful screening tools for the diagnosis of PJI after TKA and THA in the chronic [9,11,12,20,22,24,25,28,29,31,32] and acute settings [1,36] as well as in the presence of inflammatory arthritis [5]. However, the use of these tests in the presence of ALTR and corrosion is unclear with concerns over falsely positive results [6,7,10,13,21,34].…”
Section: Discussionmentioning
confidence: 99%