:The change of inflation pressure and vertical load will significantly affect the mechanical characteristics of tires, and then affect the handling stability of vehicles. However, the current research on the effect of inflation pressure on the mechanical characteristics of tires under combined slip conditions is still insufficient. In order to describe the mechanical characteristics of tires under different inflation pressures, the UniTire combined slip model considering inflation pressure effects is established. By means of experimental observation and theoretical model analysis, the influence and mechanism of the coupling effect of inflation pressure and vertical load on the key mechanical characteristics such as cornering and longitudinal slip stiffness of tires are revealed; Furthermore, by analyzing the change of the resultant shear force direction in the contact patch under combined slip conditions and the influence of the coupling effect of inflation pressure and vertical load, the expressions of the direction factor are improved, and a combined slip tire model is established considering the influence of the coupling effect of inflation pressure and vertical load. The model is extensively validated using tire test data, and the results show that the UniTire combined slip model can accurately describe the tire mechanical characteristics under a wide range of inflation pressure and vertical load changes. Key words:tire model;UniTire;tire inflation pressure;vertical load;combined slip