Inflation und Beschäftigung

Landmann, Oliver; Jerger, Jürgen

doi:10.1007/978-3-642-58531-9_4

Cited by 2 publications

(2 citation statements)

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“…The water permeability barrier function is mainly attributed to the extracellular matrix, replete with lamellar arrays of lipids, between cornified cells (Figure A). These intercellular lipids and lipid‐processing enzymes derive, for the most part, from the contents of lamellar granules (LGs), also known as lamellar bodies (Figure ) . Abnormalities in the intercellular lipid layer have been reported in various skin diseases .…”

Section: Intercellular Lipid Lamellae and Lamellar Granulesmentioning

confidence: 99%

Molecular basis of the skin barrier structures revealed by electron microscopy

Ishida‐Yamamoto

Igawa

Kishibe

2018

Experimental Dermatology

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The barrier function of skin is indispensable for terrestrial animals. This function is mainly carried out by the epidermis, more specifically by its granular and cornified layers. The major structural components associated with this function are the intercellular lipid layer, desmosomes, corneodesmosomes, tight junctions, cornified cell envelope and keratin filaments. In this review, we discuss the current knowledge of their ultrastructure, their molecular basis and their relevance to skin disease.

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Section: Intercellular Lipid Lamellae and Lamellar Granulesmentioning

confidence: 99%

Molecular basis of the skin barrier structures revealed by electron microscopy

Ishida‐Yamamoto

Igawa

Kishibe

2018

Experimental Dermatology

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“…The cells there are attached only at the cell periphery by corneodesmosomes which are modified desmosomes (3,4). These corneodesmosomes spare wide spaces at the central (non‐peripheral) area for the lipid layers to form a continuous permeability barrier (5,6). To establish this structure while maintaining steady state thickness of the stratum corneum, degradation process of corneodesmosomes must be under strict control.…”

Section: Introductionmentioning

confidence: 99%

Tight junctions in the stratum corneum explain spatial differences in corneodesmosome degradation

Igawa

Kishibe

Murakami

et al. 2010

Experimental Dermatology

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To maintain stratum corneum integrity while simultaneously desquamating at a steady rate, degradation of corneodesmosomes must proceed in a controlled manner. It is unknown why corneodesmosomes are present only at the cell periphery in the upper stratum corneum. To explore this, we studied distributions of three major corneodesmosomal components, corneodesmosin, desmoglein 1 and desmocollin 1 in normal adult human epidermis. Immunofluorescent microscopy studies of skin surface corneocytes detected all three components only at the cell edges. Immunoelectron microscopy revealed selective loss of these components at the central areas starting from the deep cornified layers. We hypothesized that tight junctions (TJs) formed in the superficial granular layer may prevent protease access by functioning as a barrier between the peripheral and the central intercellular spaces in the stratum corneum. Ultrastructural examination demonstrated TJs up to the junctions between the seventh and the eighth deepest cornified layers. Immunoelectron microscopy also detected clusters of occludin and claudin-1 immunolabels at the cell periphery, and kallikrein 7 immunolabels outside of TJs in the lower cornified layers. With colloidal lanthanum nitrate perfusion assay of stripped stratum corneum, the tracer was excluded from TJ domains. Taken together, we propose that TJs inhibit access of proteases to the peripheral corneodesmosomes forming the structural basis for the basket-weave-like appearance of the stratum corneum.

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Inflation und Beschäftigung

Cited by 2 publications

References 0 publications

Molecular basis of the skin barrier structures revealed by electron microscopy

Molecular basis of the skin barrier structures revealed by electron microscopy

Tight junctions in the stratum corneum explain spatial differences in corneodesmosome degradation

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