Influence of a bioceramic root end material and mineral trioxide aggregates on fibroblasts and osteoblasts

Bioactivity of Mineral Trioxide Aggregate and Mechanism of Action

“…In a more recent study on the attachment and proliferation of fibroblasts and osteoblasts on calcium silicate cements, it was found that human periodontal ligament fibroblasts and human osteoblasts attach and proliferate well on MTAbased materials. However, the osteoblasts exhibited lower proliferation rates compared with fibroblasts [161]. Because the two cell lines require different growth media in cell culture environments to support osteogenic differentiation of the osteoblasts, experiments on the fibroblasts and osteoblasts were performed separately.…”

Novel Bioceramic Root Repair Materials: Review of the Literature

“…According to the majority of this research, there is no statistically significant difference in terms of cytotoxicity between MTA and Biodentine [8], Calcium Enriched Mixture [29], BioAggregate [8] or EndoSequence [30]. However, the research by Jang et al [8] reveals that in comparison to MTA and BioAggregate, Biodentine releases significantly higher amounts of heavy metals (arsenic, copper, iron, manganese and zinc) when soaked in distilled water.…”

Cimentos biocerâmicos em endodontia: revisão de literatura

“…Os materiais EndoSequence Root Repair Material (ERRM) 10,13 , BioAggregate e iRoot 11 , ProRoot MTA and MTA-Angelus 13 e Endosequence BC sealer 14,18 apresentaram biocompatibilidade aceitável, não induzindo efeitos citotóxicos críticos 12 . Um material bioativo é capaz de interagir com tecidos vivos, resultando na formação de uma camada de apatita, biomineralização, na interface material-tecido 39,40 .…”

“…Assim, a avaliação da formação de apatita na superfície de um material, quando exposta a um fluido corporal simulado, é um método aprovado para examinar a bioatividade in vivo dos tecidos duros 40 . A bioatividade de materiais biocerâmicos endodônticos foi confirmada no Bioagregado 12 , EndoSequence Root Repair Material 12,18 , ProRoo tMTA 12 , iRoot SP 17 . Com relação à adaptação marginal, essa propriedade foi considerada aceitável para materiais biocerâmicos 21,22 , com elevada resistência adesiva nas paredes do canal radicular 24,25 , as quais sofrem pouca influência dos métodos de irrigação 16 .…”