Influence of a low dose of silver nanoparticles on cerebral myelin and behavior of adult rats

Dąbrowska–Bouta, Beata; Zięba, Mateusz; Orzelska‐Górka, Jolanta; Skalska, Joanna; Sulkowski, Grzegorz; Frontczak-Baniewicz, Małgorzata; Talarek, Sylwia; Listos, Joanna; Strużyńska, Lidia

doi:10.1016/j.tox.2016.07.007

Cited by 42 publications

(22 citation statements)

References 44 publications

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“…Similarly, chronic, intragastrically exposure of rats to low doses of Ag NPs resulted in the presence of silver in various parts of the brain, including the hippocampus and impairment of hippocampal dependent memory and cognitive coordination processes [101]. In contrast Dąbrowska-Bouta et al showed in their studies on male Wistar rats that Ag NPs administered in low concentration did not cause visible neurotoxicity in behavioral tests; however, more accurate studies showed abnormalities in the myelin sheaths and an altered expression of myelin proteins [102].…”

Section: In Vivo Toxicity In Mammalsmentioning

confidence: 94%

Toxicity of metallic nanoparticles in the central nervous system

Sawicki

Czajka

Matysiak‐Kucharek

et al. 2019

Nanotechnology Reviews

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Metallic nanoparticles due to their small size and unique physico-chemical characteristics have found excellent applications in various branches of industry and medicine. Therefore, for many years a growing interest has been observed among the scientific community in the improvement of our understanding of the impact of nanoparticles on the living organisms, especially on humans. Considering the delicate structure of the central nervous systemit is one of the organs most vulnerable to the adverse effects of metallic nanoparticles. For that reason, it is important to identify the modes of exposure and understand the mechanisms of the effect of nanoparticles on neuronal tissue. In this review, an attempt is undertaken to present current knowledge about metallic nanoparticles neurotoxicity based on the selected scientific publications. The route of entry of nanoparticles is described, as well as their distribution, penetration through the cell membrane and the blood-brain barrier. In addition, a study on the neurotoxicity in vitro and in vivo is presented, as well as some of the mechanisms that may be responsible for the negative effects of metallic nanoparticles on the central nervous system. Graphical abstract: This review summarizes the current knowledge on the toxicity of metallic NPs in the brain and central nervous system of the higher vertebrates.

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Section: In Vivo Toxicity In Mammalsmentioning

confidence: 94%

Toxicity of metallic nanoparticles in the central nervous system

Sawicki

Czajka

Matysiak‐Kucharek

et al. 2019

Nanotechnology Reviews

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“…Ag NMs could affect myelin ultrastruc ture and decreased the expression of myelinspecific proteins, such as 2′3′cyclic nucleotide 3′phosphodiesterase (CNP), myelinassociated glycoprotein (MAG), and myelin/oligoden drocyte glycoprotein (MOG), caused toxicity of central nervous system. [139] Apart from directly influencing the central nervous system, nanomaterials might affect brain through acting on gut micro biota. The communication between gut microbiota and the central nervous system that thus modulates behavior of human beings is emerging as an exciting concept in health.…”

Section: Effects Of Nanomaterials On Central Nervous System Through Gmentioning

confidence: 99%

The Nano–Intestine Interaction: Understanding the Location‐Oriented Effects of Engineered Nanomaterials in the Intestine

Cui

Bao

Wang

et al. 2020

Small

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The ORCID identification number(s) for the author(s) of this article can be found under https://doi.org/10.1002/smll.201907665. Engineered nanomaterials (ENMs) are used in food additives, food packages, and therapeutic purposes owing to their useful properties, Therefore, human beings are orally exposed to exogenous nanomaterials frequently, which means the intestine is one of the primary targets of nanomaterials. Consequently, it is of great importance to understand the interaction between nanomaterials and the intestine. When nanomaterials enter into gut lumen, they inevitably interact with various components and thereby display different effects on the intestine based on their locations; these are known as location-oriented effects (LOE). The intestinal LOE confer a new biological-effect profile for nanomaterials, which is dependent on the involvement of the following biological processes: nanomucus interaction, nano-intestinal epithelial cells (IECs) interaction, nanoimmune interaction, and nano-microbiota interaction. A deep understanding ofNM-induced LOE will facilitate the design of safer NMs and the development of more efficient nanomedicine for intestine-related diseases. Herein, recent progress in this field is reviewed in order to better understand the LOE of nanomaterials. The distant effects of nanomaterials coupling with microbiota are also highlighted. Investigation of the interaction of nanomaterials with the intestine will stimulate other new research areas beyond intestinal nanotoxicity. www.advancedsciencenews.com

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“…lethal dose, 50%) and phenotypically characterize the toxicity profiles (neurotoxicity, pulmonary toxicity, reproductive toxicity, etc.) of AgNPs 9 – 12 , the molecular and cellular mechanisms by which AgNPs exert adverse effects at the organismal level remain elusive.…”

Section: Introductionmentioning

confidence: 99%

Silver nanoparticles have lethal and sublethal adverse effects on development and longevity by inducing ROS-mediated stress responses

Mao

Chen

Wang

et al. 2018

Sci Rep

240

105

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Silver nanoparticles (AgNPs) are widely used in the household, medical and industrial sectors due to their effective bactericidal activities and unique plasmonic properties. Despite the promising advantages, safety concerns have been raised over the usage of AgNPs because they pose potential hazards. However, the mechanistic basis behind AgNPs toxicity, particularly the sublethal effects at the organismal level, has remained unclear. In this study, we used a powerful in vivo platform Drosophila melanogaster to explore a wide spectrum of adverse effects exerted by dietary AgNPs at the organismal, cellular and molecular levels. Lethal doses of dietary AgNPs caused developmental delays and profound lethality in developing animals and young adults. In contrast, exposure to sublethal doses, while not deadly to developing animals, shortened the adult lifespan and compromised their tolerance to oxidative stress. Importantly, AgNPs mechanistically resulted in tissue-wide accumulation of reactive oxygen species (ROS) and activated the Nrf2-dependent antioxidant pathway, as demonstrated by an Nrf2 activity reporter in vivo. Finally, dietary AgNPs caused a variety of ROS-mediated stress responses, including apoptosis, DNA damage, and autophagy. Altogether, our study suggests that lethal and sublethal doses of AgNPs, have acute and chronic effects, respectively, on development and longevity by inducing ROS-mediated stress responses.

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Influence of a low dose of silver nanoparticles on cerebral myelin and behavior of adult rats

Cited by 42 publications

References 44 publications

Toxicity of metallic nanoparticles in the central nervous system

Toxicity of metallic nanoparticles in the central nervous system

The Nano–Intestine Interaction: Understanding the Location‐Oriented Effects of Engineered Nanomaterials in the Intestine

Silver nanoparticles have lethal and sublethal adverse effects on development and longevity by inducing ROS-mediated stress responses

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