Influence of a Specific Ginger Combination on Gastropathy Conditions in Patients with Osteoarthritis of the Knee or Hip

Abstract

The ginger combination is as effective as diclofenac but safer in treating OA, being without effect on the stomach mucosa. The increased mucosal PGs synthesis in the ginger group supports an increased mucosa-protective potential. VAS; visual analogue scale, 0-100 mm.

Pilot clinical study of the effects of ginger root extract on eicosanoids in colonic mucosa of subjects at increased risk for colorectal cancer

“…In contrast, a study by Black and colleagues saw no significant difference in plasma PGE 2 levels in healthy volunteers after 28 d of taking 2.0 g of either raw or heat treated ginger root [48]. Different to previous studies, but in agreement with our results, a study in 21 people with knee and hip osteoarthritis found that 28 d of ingesting a 340 mg of a standardized ginger extract (EV.EXT 35) significantly increased levels of several prostaglandins including PGE 2 in the stomach mucosa [49]. Differences between these various studies could be due to different doses and formulations of the ginger products, the absorption and metabolism of ginger in in vivo environments; or differential effects of ginger on different tissue types or in situations of underlying inflammation.…”

“…In contrast, a study by Black and colleagues saw no significant difference in plasma PGE 2 levels in healthy volunteers after 28 d of taking 2.0 g of either raw or heat treated ginger root . Different to previous studies, but in agreement with our results, a study in 21 people with knee and hip osteoarthritis found that 28 d of ingesting a 340 mg of a standardized ginger extract (EV.EXT 35) significantly increased levels of several prostaglandins including PGE 2 in the stomach mucosa .…”

Ginger extracts influence the expression of IL-27 and IL-33 in the central nervous system in experimental autoimmune encephalomyelitis and ameliorates the clinical symptoms of disease

“…Ginger extract or its pungent constituents, including gingerol and shogaol, are also reported to have antiinflammatory activities in experimental animal models (Lee et al, 2012). The anti-inflammatory effects of ginger and its components have been reported in patients with type 2 diabetes (Priya Rani et al, 2011), osteoarthritis (Drozdov et al, 2012), rheumatoid arthritis (Ramadan and El-Menshawy, 2013), acute respiratory distress syndrome (Vahdat Shariatpanahi et al, 2013), primary dysmenorrheal (Rahnama et al, 2012) and also in experimental models of airway inflammation (Kuo et al, 2011), ulcerative colitis (El-Abhar et al, 2008, neuroinflammation (Ha et al, 2012) and gastric ulcers (Wang et al, 2011).…”

Ginger in gastrointestinal disorders: A systematic review of clinical trials

“…Nonsteroid anti‐inflammatory drugs (NSAIDs) represent as an important and prevalent medicine with common side effects of gastrointestinal (GI) tract (Solomon & Goodson, ). (Drozdov, Kim, Tkachenko, & Varvanina () investigated the GI health in 43 patients with confirmed osteoarthritis receiving 1000 mg glucosamine with either ginger (340 mg EV.EXT 35 Zingiber officinalis extract) or Diclofenac (a member of NSAIDs) per day for 4 weeks. In this study, ginger group showed significantly lowered gastrointestinal pain and no change in dyspepsia but esophagogastroduodenoscopy showed significantly increased levels of prostaglandins (PGs) PGE1, PGE2, and PGF2a in the stomach mucosa.…”