Influence of Aerobic Training and Detraining on Serum BDNF, Insulin Resistance, and Metabolic Risk Factors in Middle-Aged Men Diagnosed With Metabolic Syndrome

Damirchi, Arsalan; Tehrani, Bahram Soltani; Alamdari, Karim Azali; Babaei, Parvin

doi:10.1097/jsm.0000000000000082

Cited by 47 publications

(56 citation statements)

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“…These results suggest that vitamin D intake increases the sensitivity of insulin [73]. Although our previous studies [37,74] and others showed adequate effectiveness by regular physical activity in improving insulin resistance, OVX + AT + D showed a better response [43,75]. There are some mechanisms for the effects of vitamin D: the presence of vitamin D receptors on pancreatic β cells [76], Vitamin D-activating 1αhydroxylase is expressed in pancreatic β cells [77], the vitamin D response element in the insulin gene due to the presence of vitamin D receptors in skeletal muscle [78] and the fact that 1,25(OH)D increases the transcription of insulin receptor genes [79] and also suppresses the renin gene, reducing hyperglycemic-induced increases in renin levels in pancreatic β cells.…”

Section: Discussionmentioning

confidence: 69%

The interaction effects of aerobic exercise training and vitamin D supplementation on plasma lipid profiles and insulin resistance in ovariectomized rats

Babaei

Damirchi

Hoseini

2015

J. Exerc. Nutr, Biochem.

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Parvin Babaei, Arsalan Damirchi and Rastegar Hoseini. The interaction effects of aerobic exercise training and vitamin D supplementation on plasma lipid profiles and insulin resistance in ovariectomized rats. Vol. 19, No. 3, pp.173-182, 2015 [Purpose] The purpose of this study was to determine the interaction effects of aerobic exercise training and vitamin D supplementation on indices of obesity and plasma lipid profiles in ovariectomized (OVX) rats.[Methods] Forty female Wistar rats were divided into 5 groups: aerobic training (3 days/week for 8 weeks; AT; n = 8), aerobic training and vitamin D supplementation (OVX + AT + Vit D; n = 8), vitamin D supplementation (OVX + Vit D; n = 8), ovariectomized control (OVX + C, n = 8) and SHAM (n = 8). After blood sampling, visceral fat was taken from the abdominal cavity and weighed immediately. Data was statistically analyzed by One-way ANOVA and Repeated measure ANOVA tests with a 0.05 significance level.[Results] Body weight, visceral fat, BMI and food intake decreased significantly in OVX + AT + Vit D (P < 0.001); whereas these variables increased significantly in OVX + C (P < 0.001) and SHAM (P < 0.023) groups. At the end of two-months of follow-up, we observed significant differences in TC, TG, HDL-C, LDL-C, glucose, insulin, and HOMA-IR in all groups.[Conclusion] It seems that aerobic training with vitamin D, due to the involvement of muscle mass and exposure to dynamic pressure on the bones and muscles, increased energy expenditure, stimulated insulin exudation and glucose homeostasis, decreased insulin resistance and improved the lipid profile in ovariectomized rats.

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Section: Discussionmentioning

confidence: 69%

The interaction effects of aerobic exercise training and vitamin D supplementation on plasma lipid profiles and insulin resistance in ovariectomized rats

Babaei

Damirchi

Hoseini

2015

J. Exerc. Nutr, Biochem.

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“…13 The situation in relation to lipid parameters is similar in the adult population: they are not modified following detraining. 16,17 On the contrary, other studies have reported losses of fitness benefits gained in children 11,12 and adolescents. 14 This systematic review showed that HDL cholesterol increased following detraining, and this is confirmed upon analyzing intragroup (ES= 0.12; 95% CI 0.02-0.29) and intergroup results (ES= 0.49; 95% CI 0.18-0.81).…”

Section: Discussionmentioning

confidence: 56%

“…[11][12][13][14] In the case of adults, the situation is similar, with negative effects on lipid metabolism 15 or no changes at all. 16,17 In this context, the objective of this study was to assess the effects of detraining (cessation of scheduled physical exercise) on the lipid profile (HDL, LDL, total cholesterol [TC] and TG) of obese children.…”

Section: Introductionmentioning

confidence: 99%

Physical exercise, detraining and lipid profile in obese children: a systematic review

2014

Arch Argent Pediat

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Introduction.Detraining is the loss of improvements obtained through the participation in physical exercise/training after training cessation, an aspect that has been poorly studied in obese child population. Therefore, the purpose of this study was to assess the effects of detraining on the lipid profile (HDL, LDL, total cholesterol and triglycerides) of obese children. Population and Methods. Studies were collected through a search across seven databases. The search was limited to physical exercise programs that lasted, at least, eight weeks and the corresponding detraining, with an assessment of obese children lipid profile. Effect size (ES), 95% confidence intervals and study heterogeneity were estimated using Cochran's Q test (random effects model).Results. Five studies complied with the inclusion criteria and were selected for review (n= 330). In general, intra-group results (posttest versus detraining) indicated that, following detraining, blood levels of HDL cholesterol (ES= 0.12) and total cholesterol (ES= 1.41) were increased. Likewise, inter-group results (experimental group versus control group) confirmed the increase of HDL cholesterol following detraining (ES= 0.49). Conclusions. The results of this systematic review suggest that detraining after a physical exercise program does not lead to a significant loss of the benefits gained in relation to the lipid profile of obese children. However, given the number of analyzed studies and the heterogeneity observed in the analyses and the period defined as detraining (12 to 48 weeks), a higher number of well designed studies is required to obtain more conclusive results.

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“…13 Algo similar ocurre en población adulta respecto a los parámetros lipídicos, que se mantienen sin cambios tras el desentrenamiento. 16,17 Por el contrario, otros trabajos informan pérdidas de las ganancias observadas respecto a la condición física en niños 11,12 y adolescentes. 14 La presente revisión sistemática mostró un aumento del colesterol HDL tras el período de desentrenamiento, hecho que se constata tras analizar los resultados intra-(TE= 0,12; IC 95% 0,02-0,29) e intergrupo (TE= 0,49; IC 95% 0,18-0,81).…”

Section: Discussionunclassified

“…[11][12][13][14] Por su parte, en los adultos, ocurre algo similar y se muestran efectos negativos sobre el metabolismo lipídico 15 o no se observan cambios al respecto. 16,17 En este contexto, el objetivo del presente estudio fue evaluar los efectos del desentrenamiento (cese del ejercicio físico programado) sobre el perfil lipídico (HDL, LDL, CT y TG) en niños obesos.…”

Section: Introductionunclassified

Ejercicio físico, desentrenamiento y perfil lipídico en niños obesos: una revisión sistemática

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Influence of Aerobic Training and Detraining on Serum BDNF, Insulin Resistance, and Metabolic Risk Factors in Middle-Aged Men Diagnosed With Metabolic Syndrome

Abstract: Improved metabolic risk factors along with decreased serum BDNF in response to aerobic training and the opposite direction during the detraining emphasize the importance of physical activity in the treatment of MetS and prevention of related diseases.

Cited by 47 publications

References 40 publications

The interaction effects of aerobic exercise training and vitamin D supplementation on plasma lipid profiles and insulin resistance in ovariectomized rats

The interaction effects of aerobic exercise training and vitamin D supplementation on plasma lipid profiles and insulin resistance in ovariectomized rats

Physical exercise, detraining and lipid profile in obese children: a systematic review

Ejercicio físico, desentrenamiento y perfil lipídico en niños obesos: una revisión sistemática

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