Influence of alkane chain lengths and head groups on tethering of liposome–gold nanoparticle on gold surface for electrochemical DNA sensing and gene delivery

Bhuvana, Mohanlal; Dharuman, Venkataraman

doi:10.1016/j.snb.2015.09.031

Cited by 17 publications

(3 citation statements)

References 48 publications

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“…Vesicle-gold nanoparticles were stably grafted on a thiol monolayer (short alkane chain) modified gold electrode surface [13]. A low detection limit of DNA (10 -14 M) was obtained through electrochemical impedance spectroscopy in the presence of potassium ferrocyanide [14].…”

Section: Biomimetic Vesicles In Electrochemical Bioassaysmentioning

confidence: 99%

Biomimetic vesicles for electrochemical sensing

Lebègue

Farre

Jose

et al. 2018

Current Opinion in Electrochemistry

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Biomimetic vesicles, mainly composed of self-assembled bilayers of phospholipids, have attracted great attention for applications in the biosensor field over a number of decades, as a means to amplify the signal through encapsulated signal probes. In this review paper the most important developments in biomimetic vesicles for electrochemical biosensing within the last 2 years are presented, with a focus on the format of bioassays, their inclusion in microfluidic chip devices and their use in mimicking cell membranes. Key issues and the remaining challenges for future commercialization are analyzed.

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Section: Biomimetic Vesicles In Electrochemical Bioassaysmentioning

confidence: 99%

Biomimetic vesicles for electrochemical sensing

Lebègue

Farre

Jose

et al. 2018

Current Opinion in Electrochemistry

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“…Since their first description, 1 thiol self-assembled monolayers (SAM) on gold surfaces and nanoparticles have been widely used in a variety of technological applications, [2][3][4][5][6][7][8][9][10][11][12][13] and studied with a wealth of diffraction, [14][15][16][17][18] spectroscopic 8,[19][20][21][22][23] and other surface science techniques. 24 In addition, thiol SAMs have been modeled theoretically by several ab initio (mainly density functional theory, DFT) [25][26][27][28][29][30][31][32] and molecular mechanics 27,28,[33][34][35][36][37][38] studies.…”

Section: Introductionmentioning

confidence: 99%

Structure and stability of 7-mercapto-4-methylcoumarin self-assembled monolayers on gold: an experimental and computational analysis

Marchi

Cara

Lupi

et al. 2022

Phys. Chem. Chem. Phys.

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“…Since their first description, 1 thiol self-assembled monolayers (SAM) on gold surfaces and nanoparticles have been widely used in a variety of technological applications, [2][3][4][5][6][7][8][9][10][11][12][13] and studied with a wealth of diffraction, 14-18 spectroscopic 8, [19][20][21][22][23] and other surface science techniques. 24 In addition, thiol SAMs have been modeled theoretically by several ab initio (mainly density functional theory, DFT) [25][26][27][28][29][30][31][32] and molecular mechanics 27,28,[33][34][35][36][37][38] studies.…”

Section: Introductionmentioning

confidence: 99%

Structure and Stability of 7-mercapto-4-methylcoumarin SAM on Gold: an Experimental and Computational analysis.

Marchi¹,

Cara²,

Lupi³

et al. 2022

Preprint

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Self-assembled monolayers of 7-mercapto 4-methylcoumarin (MMC) on a flat gold surface were studied by Molecular Dynamics (MD) simulations, reference-free grazing incidence X-ray fluorescence (GIXRF) and X-ray photoemission spectroscopy (XPS), to determine the maximum monolayer density and to investigate the nature of the molecule/surface interface. In particular, the protonation state of the sulfur atom upon adsorption was analyzed, since some recent literature presented evidences for physisorbed thiols (preserving the S-H bond), unlike the common picture of chemisorbed thiyls (losing the hydrogen). MD with a specifically tailored force field was used to simulate either thiol or thiyl monolayers with increasing number of molecules, to determine the maximum dynamically stable densities. This result was refined by computing the monolayer chemical potential as a function of the density with the Bennet Acceptance Ratio method, based again on MD simulations. The monolayer density was measured with GIXRF, which provided a quantitative estimate of the number of sulfur atoms on top of flat gold surfaces embedded in a solution of MMC, to allow the formation of a dense monolayer. The sulfur core level binding energies in the same monolayers were measured by XPS, fitting the recorded spectra with the binding energies proposed in the literature for free or adsorbed thiols and thiyls, to get insight on the nature of the molecular species present in the layer.

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Influence of alkane chain lengths and head groups on tethering of liposome–gold nanoparticle on gold surface for electrochemical DNA sensing and gene delivery

Cited by 17 publications

References 48 publications

Biomimetic vesicles for electrochemical sensing

Biomimetic vesicles for electrochemical sensing

Structure and stability of 7-mercapto-4-methylcoumarin self-assembled monolayers on gold: an experimental and computational analysis

Structure and Stability of 7-mercapto-4-methylcoumarin SAM on Gold: an Experimental and Computational analysis.

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