Influence of an Exergaming Training Program on Reducing the Expression of IL-10 and TGF-β in Cancer Patients

Alves, Ricardo da Silva; Abdalla, Douglas Reis; Iunes, Denise Hollanda; Mariano, Karina Oliveira Prado; Borges, Juliana Bassalobre Carvalho; Murta, Eddie Fernando Cândido; Michelin, Márcia Antoniazi; Carvalho, Leonardo César

doi:10.1089/g4h.2020.0022

Cited by 7 publications

(10 citation statements)

References 33 publications

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“…It has been reported [ 22 ] that Treg-related cytokines (IL-10 and TGF- β ) show abnormal changes when the immune function of the body is disturbed. In this study, the levels of CD4 + CD25 + Treg, IL-10, and TGF- β in the death group were significantly higher than those in the survival group, indicating that patients with increased CD4 + CD25 + Treg and high expression of IL-10 and TGF- β had a higher prognosis.…”

Section: Discussionmentioning

confidence: 99%

Clinical Factors of Blood Transfusion-Related Acute Lung Injury and Changes in Levels of Treg-Related Cytokines

Sun

Liu

2022

Emergency Medicine International

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Objective. Analysis of clinical factors and changes in regulatory T cell (Treg)-related cytokine levels in transfusion-associated acute lung injury (TRALI). Methods. 62 patients who underwent blood transfusion and developed TRALI (TRALI group) in our hospital between January 2018 and December 2021 and 58 patients who did not develop TRALI (non-TRALI group) from blood transfusion were selected to collect clinical data from patients and construct a logistic regression model to analyze clinical risk factors for TRALI. Based on the prognosis of TRALI patients, they were divided into survival group (50 cases) and death group (12 cases), and serum CD4 + CD25 + Treg and Treg-related cytokines (interleukin 10 (IL-10), transforming growth factor-β (TGF-β)) levels were compared between the two groups, and the correlation between CD4 + CD25 + Treg and IL-10 and TGF-β was analyzed by Pearson. Results. The differences in smoking history, human leukocyte antigen (HLA) antibody II, pretransfusion shock, and CD4 + CD25 + Treg between the TRALI group and non-TRALI group were statistically significant ( P < 0.05 ). Logistic regression analysis showed that HLA antibody II and increased CD4 + CD25 + Treg were independent risk factors of TRALI ( P < 0.05 ). The levels of CD4 + CD25 + Treg, IL-10, and TGF-β in the death group were significantly higher than those in the survival group ( P < 0.05 ). CD4 + CD25 + Treg was positively correlated with levels of IL-10 and TGF-β ( P < 0.05 ). Conclusion. Elevated HLA antibody II and CD4 + CD25 + Treg are the main clinical risk factors for TRALI, and CD4 + CD25 + Treg may be involved in immunosuppression by increasing the expression levels of IL-10 and TGF-β. Early clinical monitoring of changes in Treg-related cytokine levels can provide some guidance for prognostic assessment of TRALI patients.

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Section: Discussionmentioning

confidence: 99%

Clinical Factors of Blood Transfusion-Related Acute Lung Injury and Changes in Levels of Treg-Related Cytokines

Sun

Liu

2022

Emergency Medicine International

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“…Regarding the influence of physical activity on the immune system in the presence of tumors, preclinical and clinical studies show that practicing physical activity changes the patterns of immune responses to antitumor cellular profiles, at systemic and intratumoral levels, leading to the control of the inflammatory state and potentiating a response of rejection to the tumor, with synthesis of cytokines of profile 1 of T helper lymphocytes, profile 1 of macrophages and improving the maturation of dendritic cells [17][18][19][20][21].…”

Section: Discussionmentioning

confidence: 99%

Influence of Physical Activity in Patients with Prostate Cancer Undergoing Radiotherapy and/or Hormonal Deprivation Therapy: Integrative Literature Review

Ávila¹,

Dias²,

Pereira³

et al. 2021

Int J Sports Exerc Med

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Introduction: In Brazil and in the world, the incidence and prevalence of prostate cancer have been increasing. The prostate is a male gland responsible for the production of part of the semen. More than any other type, it is considered a cancer of the third age, since about 75% of the cases in the world occur from the age of 65. In this study it was correlated the practice of physical exercises with the progression and evolution of the disease beyond the impacts in the treatment.Aim: This work aimed to verify in the literature the impacts of regular physical activity on patients with prostate cancer under treatment and after treatment.Methods: Systematic search of scientific articles published between 2010 and 2020 in the PubMed database, using the descriptors: Prostate cancer, Physical activity, Exercise, Quality of life and Lifespan. After complete analysis of the publications, seven articles met all inclusion criteria. Results: Overall improvement was observed in those patients who started the physical activity program, as well as improvement in quality of life, physical function, weight, body fat, well-being-psychological and reduction of cardiovascular risk, weight, fatigue, blood markers and inflammatory cytokines. Conclusion:Physical activity is an additional resource in the treatment of patients with prostate cancer.

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“…The duration of interventions ranged from 2 to 16 weeks, with a minimum of 2 sessions per week [37,38] and a maximum of 1 daily session [34,39]. Sessions were supervised in 10 studies [33,[35][36][37][39][40][41][42][43][44][45][46][47], and 7 included home-based interventions [34,38,[48][49][50][51][52][53]. Regarding exergames, 7 trials used Xbox Kinect, 8 trials used Nintendo Wii, and 2 trials created its own exergame and software.…”

Section: Study Characteristicsmentioning

confidence: 99%

Effects of Active Video Games in Patients With Cancer: Systematic Review

Peyrachon,

Rébillard

2023

JMIR Cancer

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Background Physical activity (PA) is now considered an adjuvant therapy in cancer treatment; nevertheless, multiple barriers could reduce PA engagement during treatment. Active video games (AVGs) lead to the achievement of mild- to moderate-intensity PA and represent a promising tool for regular movement and exercise. Objective This paper aims to review the current literature and provide updated content on the physiological and psychological effects of AVG-based interventions in patients with cancer undergoing treatment. Methods Four electronic databases were investigated. Studies reporting on AVG interventions delivered to patients undergoing treatment were included. A total of 21 articles (17 interventions) were identified for data extraction and quality assessment. Results A total of 362 patients with cancer participated in the studies (number of participants 3-70). The majority underwent treatment for breast, lung, prostate, hematologic, or oral or laryngeal cancer. The types and stages of cancer varied in all studies. Participants ranged in age from 3 to 93 years. Four studies included patients with pediatric cancer. The duration of interventions ranged from 2 to 16 weeks, with a minimum of 2 sessions per week and a maximum of 1 daily session. Sessions were supervised in 10 studies, and 7 included home-based interventions. AVG interventions improved endurance, quality of life, cancer-related fatigue, and self-efficacy. Effects were mixed on strength, physical function, and depression. AVGs did not affect activity level, body composition, or anxiety. Compared with standard physiotherapy, physiological effects were lower or similar, and psychological effects were higher or similar. Conclusions Overall, our results suggest that AVGs can be recommended to patients undergoing cancer treatment, given the physiological and psychological benefits. When AVGs are proposed, supervision of the sessions should be considered as it can limit dropouts. In the future, it is important to develop AVGs that combine endurance and muscle strengthening, with the possibility of achieving moderate to high exercise intensity, depending on the physical abilities of the patients, as indicated in the World Health Organization’s recommendations.

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Influence of an Exergaming Training Program on Reducing the Expression of IL-10 and TGF-β in Cancer Patients

Cited by 7 publications

References 33 publications

Clinical Factors of Blood Transfusion-Related Acute Lung Injury and Changes in Levels of Treg-Related Cytokines

Clinical Factors of Blood Transfusion-Related Acute Lung Injury and Changes in Levels of Treg-Related Cytokines

Influence of Physical Activity in Patients with Prostate Cancer Undergoing Radiotherapy and/or Hormonal Deprivation Therapy: Integrative Literature Review

Effects of Active Video Games in Patients With Cancer: Systematic Review

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