Influence of childhood trauma, HIV infection, alcohol use disorder, and resilience on health-related quality of life in adulthood

Sassoon, Stephanie A.; Fama, Rosemary; Berre, Anne‐Pascale Le; Müller‐Oehring, Eva M.; Zahr, Natalie M.; Pfefferbaum, Adolf; Sullivan, Edith V.

doi:10.1016/j.jpsychires.2023.05.033

Cited by 3 publications

(1 citation statement)

References 47 publications

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“…Studies examining the comorbidity effects of HIV infection and AUD on brain structure and function report shrinkage, particularly in the frontal cortex ( Pfefferbaum et al, 2018 ) with impairment in working memory, visuospatial abilities, and psychomotor speed ( Rosenbloom et al, 2010 ). Moreover, trauma in conjunction with AUD and HIV infection comorbidity has been found to be associated with poorer episodic memory ( Sassoon et al, 2017 ) and compromised quality of life ( Sassoon et al, 2023 ).…”

Section: Introductionmentioning

confidence: 99%

Frontal cortical volume deficits as enduring evidence of childhood abuse in community adults with AUD and HIV infection comorbidity

Sassoon,

Fama,

Pohl

et al. 2024

Neurobiology of Stress

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Section: Introductionmentioning

confidence: 99%

Frontal cortical volume deficits as enduring evidence of childhood abuse in community adults with AUD and HIV infection comorbidity

Sassoon,

Fama,

Pohl

et al. 2024

Neurobiology of Stress

Self Cite

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The role of resilience in the relationship between stress and alcohol

Schwandt,

Cullins,

Ramchandani

2024

Neurobiology of Stress

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From childhood trauma to alcohol use disorder severity – significance of depressive symptoms and expectations towards analgesic effects of alcohol

Zaorska,

Skrzeszewski,

Kobyliński

et al. 2024

Alcohol and Alcoholism

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Aims The objective of the current study was to describe and analyse associations between childhood emotional abuse, severity of depressive symptoms, and analgesic expectations of drinking in individuals with alcohol use disorder (AUD). Methods A total of 240 individuals aged 43.85 ± 11.0 with severe AUD entering an inpatient, abstinence-based, and drug-free treatment program were assessed. The data on AUD severity, depressive symptoms, expectations towards the analgesic effects of alcohol and childhood emotional trauma was collected using questionnaire measures. The PROCESS SPSS macro for serial mediation with bootstrapping was used to test whether current severity of depressive symptoms and expectations towards analgesic effects of alcohol use serially mediated the association between childhood emotional abuse on AUD symptom severity. Results There was evidence for two simple mediated effects, whereby the severity of depressive symptoms mediated the association between childhood emotional abuse on AUD symptom severity, and expectations towards analgesic effects of alcohol mediated the association between childhood emotional abuse on AUD symptom severity. There was also evidence to support serial mediation whereby both severity of depressive symptoms and expectations towards analgesic effects of alcohol mediated the association between childhood emotional abuse on AUD symptom severity. Conclusions It might be clinically relevant to address experiences of childhood emotional trauma, as well as individual expectations of analgesic effects of alcohol, in AUD treatment programs.

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Influence of childhood trauma, HIV infection, alcohol use disorder, and resilience on health-related quality of life in adulthood

Cited by 3 publications

References 47 publications

Frontal cortical volume deficits as enduring evidence of childhood abuse in community adults with AUD and HIV infection comorbidity

Frontal cortical volume deficits as enduring evidence of childhood abuse in community adults with AUD and HIV infection comorbidity

The role of resilience in the relationship between stress and alcohol

From childhood trauma to alcohol use disorder severity – significance of depressive symptoms and expectations towards analgesic effects of alcohol

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