Influence of Diet on the Effect of the Probiotic Lactobacillus paracasei in Rats Suffering From Allergic Asthma

Xie, Ao; Song, Jia-ping; Lü, Shan; Liu, Yinhui; Tang, Li; Wen, Shu

doi:10.3389/fmicb.2021.737622

Cited by 8 publications

(5 citation statements)

References 71 publications

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“…The main products are lactic acid, acetic acid and formic acid, and those are also SCFAs. Enterococcus and Enterococcaceae (Byappanahalli et al, 2012;Gouba et al, 2020;Xie et al, 2021) are conditional pathogens, causing infections such as urinary tract infections, purulent abdominal infections, sepsis, endocarditis and diarrhea. On the other hand, their microbial preparations can enhance the activity of macrophage cells and promote the immune response.…”

Section: Discussionmentioning

confidence: 99%

Alterations of the Gut Microbiota in Patients With Severe Chronic Heart Failure

Sun

Du²,

et al. 2022

Front. Microbiol.

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Chronic heart failure (CHF) is the final outcome of almost all forms of cardiovascular diseases, remaining the main cause of mortality worldwide. Accumulating evidence is focused on the roles of gut microbial community in cardiovascular disease, but few studies have unveiled the alterations and further directions of gut microbiota in severe CHF patients. Aimed to investigate this deficiency, fecal samples from 29 CHF patients diagnosed with NYHA Class III-IV and 30 healthy controls were collected and then analyzed using bacterial 16S rRNA gene sequencing. As a result, there were many significant differences between the two groups. Firstly, the phylum Firmicutes was found to be remarkably decreased in severe CHF patients, and the phylum Proteobacteria was the second most abundant phyla in severe CHF patients instead of phylum Bacteroides strangely. Secondly, the α diversity indices such as chao1, PD-whole-tree and Shannon indices were significantly decreased in the severe CHF versus the control group, as well as the notable difference in β-diversity between the two groups. Thirdly, our result revealed a remarkable decrease in the abundance of the short-chain fatty acids (SCFA)-producing bacteria including genera Ruminococcaceae UCG-004, Ruminococcaceae UCG-002, Lachnospiraceae FCS020 group, Dialister and the increased abundance of the genera in Enterococcus and Enterococcaceae with an increased production of lactic acid. Finally, the alternation of the gut microbiota was presumably associated with the function including Cell cycle control, cell division, chromosome partitioning, Amino acid transport and metabolism and Carbohydrate transport and metabolism through SCFA pathway. Our findings provide the direction and theoretical knowledge for the regulation of gut flora in the treatment of severe CHF.

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Section: Discussionmentioning

confidence: 99%

Alterations of the Gut Microbiota in Patients With Severe Chronic Heart Failure

Sun

Du²,

et al. 2022

Front. Microbiol.

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“…Additionally, Romboutsia species, such as Romboutsia sedimentorum (31) and Romboutsia ilealis (32), were capable to apply carbohydrates and glucose to create short-chain fatty acids(SCFAs). In a mouse model, SCFAs inhibited hypertension-induced cardiac inflammatory responses, myocardial hypertrophy, and fibrosis (33)(34)(35). Previous studies have found that corticosterone can combine with and activate mineralocorticoid receptors, leading to sodium retention, which can lead to increased blood pressure (36,37).…”

Section: Discussionmentioning

confidence: 97%

Alteration of the gut microbiota and metabolite phenylacetylglutamine in patients with severe chronic heart failure

Zhang

Cai

Sun

et al. 2023

Front. Cardiovasc. Med.

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Chronic Heart Failure (CHF) is the end result of nearly all cardiovascular disease and is the leading cause of deaths worldwide. Studies have demonstrated that intestinal flora has a close relationship with the development of Cardiovascular Disease (CVD) and plays a vital role in the disease evolution process. Phenylacetylglutamine (PAGln) a metabolite of the intestinal flora, is one of the common chronic kidney disease toxins. Its concentrations in plasma were higher in patients with major adverse cardiovascular events (MACE) however, its variation in patients with various degrees of CHF has rarely been reported. Therefore, we collected stool and plasma samples from 22 healthy controls, 29 patients with NYHA Class III and 29 patients with NYHA Class IV CHF (NYHA stands for New York Heart Association) from the Department of Cardiology of Shanghai Fengxian District Central Hospital. Next, we analyzed these samples by performing bacterial 16S ribosomal RNA gene sequencing and liquid chromatography tandem mass spectrometry. The result shows: The Chao 1 index was significantly lower in both NYHA class III and NYHA class IV than it was in the control group. The beta diversity was substantially dissimilar across the three groups. The linear discriminant analysis effect size analysis (LEfSe) showed that the bacterial species with the largest differences were Lachnospiraceae in control group, Enterobacteriaceae in NYHA class III, and Escherichia in NYHA class IV. The concentration of PAGln was significantly different between CHF and control groups and increased with the severity of heart failure. Finally, the correlation analysis represented that Parabacteroides and Bacteroides were negatively correlated to brain natriuretic peptide (BNP) and PAGln; Romboutsia and Blautia adversely associated with PAGln; Klebsiella was positively interrelated with BNP; Escherichia-Shigella was positively correlated with PAGln and BNP; Alistipes was contrasted with BNP; and Parabacteroides was negatively correlated with the left ventricular end-diastolic diameter (LVEDD). This study presented that the intestinal flora and its metabolite PAGln were altered with different grades of CHF and illustrated the effects of the gut flora and its metabolite on CHF.

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“…In the HFrEF group, wealso observed a relatively increased abundance of Enterococcaceaewhich are conditional pathogens, causing infections such as urinary tract infections, purulent abdominal infections, sepsis, endocarditis, and diarrhea [ 37 , 38 , 39 , 40 , 41 , 42 ]. These results are in agreement with the findings of Sun W et al (2022) which showed that the increase of the genera in Enterococcus and Enterococcaceaewere also the most notable features in heart failure patients [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

Diversities in the Gut Microbial Patterns in Patients with Atherosclerotic Cardiovascular Diseases and Certain Heart Failure Phenotypes

et al. 2022

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To continue progress in the treatment of cardiovascular disease, there is a need to improve the overall understanding of the processes that contribute to the pathogenesis of cardiovascular disease (CVD). Exploring the role of gut microbiota in various heart diseases is a topic of great interest since it is not so easy to find such reliable connections despite the fact that microbiota undoubtedly affect all body systems. The present study was conducted to investigate the composition of gut microbiota in patients with atherosclerotic cardiovascular disease (ASCVD) and heart failure syndromes with reduced ejection fraction (HFrEF) and HF with preserved EF (HFpEF), and to compare these results with the microbiota of individuals without those diseases (control group). Fecal microbiota were evaluated by three methods: living organisms were determined using bacterial cultures, total DNA taxonomic composition was estimated by next generation sequencing (NGS) of 16S rRNA gene (V3–V4) and quantitative assessment of several taxa was performed using qPCR (quantitative polymerase chain reaction). Regarding the bacterial culture method, all disease groups demonstrated a decrease in abundance of Enterococcus faecium and Enterococcus faecalis in comparison to the control group. The HFrEF group was characterized by an increased abundance of Streptococcus sanguinus and Streptococcus parasanguinis. NGS analysis was conducted at the family level. No significant differences between patient’s groups were observed in alpha-diversity indices (Shannon, Faith, Pielou, Chao1, Simpson, and Strong) with the exception of the Faith index for the HFrEF and control groups. Erysipelotrichaceae were significantly increased in all three groups; Streptococcaceae and Lactobacillaceae were significantly increased in ASCVD and HFrEF groups. These observations were indirectly confirmed with the culture method: two species of Streptococcus were significantly increased in the HFrEF group and Lactobacillus plantarum was significantly increased in the ASCVD group. The latter observation was also confirmed with qPCR of Lactobacillus sp. Acidaminococcaceae and Odoribacteraceae were significantly decreased in the ASCVD and HFrEF groups. Participants from the HFpEF group showed the least difference compared to the control group in all three study methods. The patterns found expand the knowledge base on possible correlations of gut microbiota with cardiovascular diseases. The similarities and differences in conclusions obtained by the three methods of this study demonstrate the need for a comprehensive approach to the analysis of microbiota.

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Influence of Diet on the Effect of the Probiotic Lactobacillus paracasei in Rats Suffering From Allergic Asthma

Cited by 8 publications

References 71 publications

Alterations of the Gut Microbiota in Patients With Severe Chronic Heart Failure

Alterations of the Gut Microbiota in Patients With Severe Chronic Heart Failure

Alteration of the gut microbiota and metabolite phenylacetylglutamine in patients with severe chronic heart failure

Diversities in the Gut Microbial Patterns in Patients with Atherosclerotic Cardiovascular Diseases and Certain Heart Failure Phenotypes

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