This case report presents a 22-year-old male who exhibited critically high levels of creatine kinase (CK) (3,600 U/L), elevated liver transaminases (alanine aminotransferase (ALT) 90 U/L; aspartate aminotransferase (AST) 54 U/L), and elevated total bilirubin (30 µmol/L) following vigorous physical activity. The patient’s blood work parameters normalized after a short period of exercise abstinence, highlighting the impact of acute exercise on blood work parameters and the importance of considering recent physical activity when interpreting laboratory results.