Influence of formulation parameters on encapsulation of doxycycline in PLGA microspheres prepared by double emulsion technique for the treatment of periodontitis

Ali, Muhanad; Walboomers, X. Frank; Jansen, John A.; Yang, Fang

doi:10.1016/j.jddst.2019.04.031

Cited by 42 publications

(25 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PLGA microspheres loaded with BSA-Rhod at the theoretical loading of 0.25% (0.25 mg of BSA-Rhod per 100 mg of microspheres) were prepared by the double emulsion-solvent evaporation technique [ 23 , 40 , 41 , 42 ]. First, an internal aqueous phase was prepared by dissolving BSA-Rhod in 0.30 mL of water and poured into an organic phase composed of 3.0 mL of a PLGA solution in methylene chloride (10, 15 and 20% weight-to-volume ( w / v) ; correspondingly the formulations were named PLGA10, PLGA15, and PLGA20).…”

Section: Methodsmentioning

confidence: 99%

Experimental Studies and Modeling of the Degradation Process of Poly(Lactic-co-Glycolic Acid) Microspheres for Sustained Protein Release

Netti

Frigione

2020

Polymers

View full text Add to dashboard Cite

In this study, poly(lactic-co-glycolic acid) microspheres (PLGA MS)for controlled protein release by double emulsion-solvent evaporation were produced and characterized for their morphological and technological features. MS autocatalytic degradation was described by a mathematical model based on a Michaelis and Menten-like chemical balance. Here, for the first time MS degradation was correlated to the advancement of MS degradation front with respect to the degraded radius, derived from mass loss experiments. The model can satisfactorily describe the kinetics of advancement of the degradation front experimentally derived for all MS formulations, especially when produced at higher PLGA concentrations.

show abstract

Section: Methodsmentioning

confidence: 99%

Experimental Studies and Modeling of the Degradation Process of Poly(Lactic-co-Glycolic Acid) Microspheres for Sustained Protein Release

Netti

Frigione

2020

Polymers

View full text Add to dashboard Cite

show abstract

“…The Yang group at Radboud University Medical Center, Netherlands, has been developing nanomaterials for electrospinning and/or electrospraying to produce scaffolds for drug delivery and/or defected tissue repair . At the meeting, they reported the preparation of drug‐loaded poly (lactic‐ co ‐glycolic acid) (PLGA) microspheres by electrospraying, which showed advantages such as a short exposure time of drugs to organic solvents and a high encapsulation efficiency.…”

Section: Scaffolds Based Upon Electrospun Nanofibers For Biomedical Amentioning

confidence: 99%

Moving Electrospun Nanofibers and Bioprinted Scaffolds toward Translational Applications

Xia

2020

Adv Healthcare Materials

View full text Add to dashboard Cite

Over the past two decades, electrospun nanofibers have been actively explored for a range of applications, including those related to biomedicine, environmental science, energy harvesting, catalysis, photonics, and electronics. Regarding biomedical applications, one can readily produce nanofiber‐based scaffolds with controlled compositions, structures, alignments, and functions by varying the material, design of collector, number of spinnerets, and electrospinning parameters. This report highlights both preclinical and translational applications of electrospun nanofibers and bioprinted constructs presented at the 2019 International Conference on Electrospinning, together with some perspectives on their future development.

show abstract

“…This result is presented with the corresponding zeta potential (Figure 3) and swelling degree (Figure 8). The NCH‐CMC/PLGA nanocarriers in this research were synthesized from acid‐terminated PLGA resulting PLGA has carboxylic (PLGA−COOH) in the end group [43] . When the nanocarriers adsorbed water, the PLGA−COOH was degraded from end group capable of donating a proton (H + ).…”

Section: Resultsmentioning

confidence: 99%

“…The NCH-CMC/PLGA nanocarriers in this research were synthesized from acid-terminated PLGA resulting PLGA has carboxylic (PLGAÀ COOH) in the end group. [43] When the nanocarriers adsorbed water, the PLGAÀ COOH was degraded from end group capable of donating a proton (H + ). The activity of H + is responsible for the elimination of ester backbone in PLGA undergoes hydrolysis.…”

Section: In Vitro Drug Release Profiles Of the Nch-cmc/plga Nanocarriersmentioning

confidence: 99%

Kinetics of Drug Release via Nicardipine Hydrochloride‐loaded Carboxymethyl Cellulose/Poly(D,L‐lactic‐co‐glycolic acid) Nanocarriers Using a Contemporary Emulsion Process

et al. 2020

View full text Add to dashboard Cite

A contemporary synthesis of polymeric nanocarriers based on drug delivery systems was employed using a water in oil in water (W 1 /O/W 2) double emulsion process to develop nicardipine hydrochloride-loaded carboxymethyl cellulose/ poly(D,L-lactic-co-glycolic acid) (NCH-CMC/PLGA) nanocarriers. The optimal synthesis of the nanocarriers was studied, including polymer amount, cross-linker concentration, and emulsifier concentration. The synthesized nanocarriers were smaller than~169 nm and showed a drug encapsulation of more than 80% and a yield of 51% to 73%. The NCH-CMC/ PLGA nanocarriers presented good stability in aqueous dispersion for 10 days. Controlled drug release from the nanocarriers was slow and continuous for up to 16 days. The nanocarriers protected the drug against degradation and maintained therapeutic drug concentrations. In addition, the transport of drug release was studied via five conventional mathematical modelings such as Zero-order model, Firstorder model, Hixson-Crowell model, Higuchi model, and Korsmeyer-Peppas model. The Korsmeyer-Peppas model was fitted to achieve mathematical modeling for the optimized formulation of nanocarriers. Moreover, significant cytocompatibility was observed at all tested doses of NCH-CMC/PLGA nanocarriers. The NCH-CMC/PLGA nanocarriers could be an effective drug delivery agent for calcium channel blockers.

show abstract

Influence of formulation parameters on encapsulation of doxycycline in PLGA microspheres prepared by double emulsion technique for the treatment of periodontitis

Cited by 42 publications

References 31 publications

Experimental Studies and Modeling of the Degradation Process of Poly(Lactic-co-Glycolic Acid) Microspheres for Sustained Protein Release

Experimental Studies and Modeling of the Degradation Process of Poly(Lactic-co-Glycolic Acid) Microspheres for Sustained Protein Release

Moving Electrospun Nanofibers and Bioprinted Scaffolds toward Translational Applications

Kinetics of Drug Release via Nicardipine Hydrochloride‐loaded Carboxymethyl Cellulose/Poly(D,L‐lactic‐co‐glycolic acid) Nanocarriers Using a Contemporary Emulsion Process

Contact Info

Product

Resources

About