Influence of Gd doping on gas sensing performance of Gd-(ZnO/TiO2) nanocomposites

Panwar, Sagar; Kumar, Vinod; Purohit, L.P.

doi:10.1016/j.optmat.2023.113919

Cited by 4 publications

(1 citation statement)

References 63 publications

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“…A strong diffraction peak at 2θ = 11.96° corresponds to the (002) GO plane in Figure L,a) . The distinctive peaks at 2θ positions of 25.28°, 36.28°, 37.48°, 47.84°, 54°, 55.9°, 62.44°, 68.36°, and 69.8° originating from (101), (103), (004), (200), (105), (211), (204), (116), and (220) crystal planes depict the anatase phase, repsectively, ,− whereas a peak at 39.4° indexed by (112) plane manifest rutile phase of TiO 2 nanoparticles (Figure L,b) . However, the appearance of GO and TiO 2 diffraction peaks in TiO 2 –GO nanocomposites with slightly lower intensities provides obvious clues for TiO 2 nanoparticle formation over GO (Figure L,c).…”

Section: Resultsmentioning

confidence: 99%

Titania–Graphene Oxide Nanocomposite-Based Philadelphia-Positive Leukemia Therapy

Batool,

Qazi,

Mudassir

et al. 2024

ACS Appl. Bio Mater.

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Philadelphia-positive (Ph+) leukemia is a type of blood cancer also known as acute lymphoblastic leukemia (ALL), affecting 20−30% of adults diagnosed worldwide and having an engraved prognosis as compared to other types of leukemia. The current treatment regimens mainly rely on tyrosine kinase inhibitors (TKIs) and bone marrow transplants. To date, several generations of TKIs have been developed due to associated resistance and frequent relapse, with cardiovascular system anomalies being the most devastating complication. Nanotechnology has the potential to address these limitations by the targeted drug delivery and controlled release of TKIs. This study focused on the titanium dioxide (TiO 2 ) and graphene oxide (GO) nanocomposite employment to load nilotinib and ponatinib TKIs for therapy of Ph+ leukemia cell line (K562) and Ba/F3 cells engineered to express BCR-ABL oncogene. Meanwhile, after treatment, the oncogene expressing fibroblast cells (Rat-1 P185) were evaluated for their colony formation ability under 3D conditions. To validate the nanocomposite formation, the TiO 2 −GO nanocomposites were characterized by scanning electron microscope, DLS, XRD, FTIR, zeta potential, EDX, and element mapping. The TKI-loaded TiO 2 −GO was not inferior to the free drugs after evaluating their effects by a cell viability assay (XTT), apoptosis induction, and colony formation inhibition. The cell signaling pathways of the mammalian target of rapamycin (mTOR), signal transducers and activators of transcription 5 (STAT5), and extracellular signal-regulated kinase (Erk1/2) were also investigated by Western blot. These signaling pathways were significantly downregulated in the TKI-loaded TiO 2 −GO-treated groups. Based on the findings above, we can conclude that TiO 2 −GO exhibited excellent drug delivery potential that can be used for Ph+ leukemia therapy in the future, subject to further investigations.

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