Influence of Human B-Casomorphin-7 on Specific Binding of 3H-Spiperone to the 5-HT2-Receptors of Rat Brain Frontal Cortex

Sokolov, O. Yu.; Кост, Н. В.; Zolotarev, Yu. A.; Ryukert, Ekaterina Nikolaevna; Zozulya, A. A.

doi:10.2174/092986606775101733

Cited by 6 publications

(2 citation statements)

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“…However, it is evident that A1 stimulates production of the enzyme DPP-4 in the rat jejunum through a nonopioid mechanism ( 39 ). It is also known that BCMs are 5-hydroxytryptamine2 (5HT2)-serotonin receptor antagonists through an unrelated mechanism ( 52 – 54 ). Furthermore, recent research has shown that A1 compared with A2 has implications for casein micelle structure and associated chaperone activity within the gastrointestinal system that is unrelated to opioid mechanisms ( 55 ).…”

Section: Discussionmentioning

confidence: 99%

Systematic Review of the Gastrointestinal Effects of A1 Compared with A2 β-Casein

Brooke‐Taylor¹,

Dwyer

Woodford

et al. 2017

Advances in Nutrition

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111

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This is the first systematic review, to our knowledge, of published studies investigating the gastrointestinal effects of A1-type bovine β-casein (A1) compared with A2-type bovine β-casein (A2). The review is relevant to nutrition practice given the increasing availability and promotion in a range of countries of dairy products free of A1 for both infant and adult nutrition. In vitro and in vivo studies (all species) were included. In vivo studies were limited to oral consumption. Inclusion criteria encompassed all English-language primary research studies, but not reviews, involving milk, fresh-milk products, β-casein, and β-casomorphins published through 12 April 2017. Studies involving cheese and fermented milk products were excluded. Only studies with a specific gastrointestinal focus were included. However, inclusion was not delimited by specific gastrointestinal outcome nor by a specific mechanism. Inclusion criteria were satisfied by 39 studies. In vivo consumption of A1 relative to A2 delays intestinal transit in rodents via an opioid-mediated mechanism. Rodent models also link consumption of A1 to the initiation of inflammatory response markers plus enhanced Toll-like receptor expression relative to both A2 and nonmilk controls. Although most rodent responses are confirmed as opioid-mediated, there is evidence that dipeptidyl peptidase 4 stimulation in the jejunum of rodents is via a nonopioid mechanism. In humans, there is evidence from a limited number of studies that A1 consumption is also associated with delayed intestinal transit (1 clinical study) and looser stool consistency (2 clinical studies). In addition, digestive discomfort is correlated with inflammatory markers in humans for A1 but not A2. Further research is required in humans to investigate the digestive function effects of A1 relative to A2 in different populations and dietary settings.

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Section: Discussionmentioning

confidence: 99%

Systematic Review of the Gastrointestinal Effects of A1 Compared with A2 β-Casein

Brooke‐Taylor¹,

Dwyer

Woodford

et al. 2017

Advances in Nutrition

Self Cite

111

View full text Add to dashboard Cite

show abstract

“…However, there are no recent studies to confirm this hypothesis. Recently, one research group has suggested a possible interaction of BCM7 with serotonin systems (Sokolov et al, 2005(Sokolov et al, , 2006(Sokolov et al, , 2008.…”

Section: Other Activities Of Food-derived Opioid Peptidesmentioning

confidence: 99%