Influence of interleukin gene polymorphisms on development of acute pancreatitis: a systematic review and meta-analysis

Abstract

Several epidemiological studies have assessed the associations of interleukin (IL) gene polymorphisms with acute pancreatitis (AP) in different populations. However, the results were inconclusive. Therefore, we performed the present study to comprehensively evaluate the associations of IL gene polymorphisms and susceptibility to AP. Systematic searches of the PubMed, Web of Science, Embase, CNKI, CBMdisc and Google Scholar until February 27, 2013, as well as hand searching of the references of identified articles were performed. Data were extracted using standardized forms and odds ratios (ORs) with 95 % confidence intervals (CIs) were used to assess the strength of associations. All statistical analyses were performed using Stata 11.0. Ten studies were included in our final combined analysis, covering a total of 1,220 AP cases and 1,351 controls. The results showed evidence for significant association between IL-8 -251 T/A (rs4073) polymorphism and AP risk, suggesting that IL-8 -251 A allele was associated with an increased risk of AP (for A allele vs. T allele: OR = 1.36, 95 % CI 1.05-1.76, p = 0.02; for A/A vs. T/T: OR = 2.28, 95 % CI 1.08-4.81, p = 0.03; for A/A+T/A vs. T/T: OR = 1.40, 95 % CI 1.11-1.77, p = 0.005). However, there were no significant associations between IL-1β (IL-1β +3954 C/T (rs1143634) and IL-1β -511 C/T (rs16944)), IL-6 (IL-6 -174 G/C (rs1800795) and IL-6 -634 C/G (rs1800796)) and IL-10 (IL-10 -1082 A/G (rs1800896), IL-10 -819 C/T (rs1800871) and IL-10 -592 C/A (rs1800872)) gene polymorphisms and AP risk. In summary, the current study suggests that the IL-8 -251 T/A polymorphism is associated with an increased risk of AP. In addition, there were no significant associations between IL-1β, IL-6 and IL-10 gene polymorphisms and AP risk.

Association between IL-1β, IL-8, and IL-10 polymorphisms and risk of acute pancreatitis

“…In recent years, several studies have reported the association between gene polymorphisms and risk of acute pancreatitis (Ozhan et al, 2010;Yin et al, 2012Yin et al, , 2013. In this study, we found that IL-8 -251T/A polymorphisms were associated with risk of acute pancreatitis.…”

IL-8 -251T/A polymorphism is associated with susceptibility to acute pancreatitis

“…However, the detailed etiology underlying AP remains unclear. Previous studies showed that inflammatory cytokines are important risk factors of AP (Gu et al, 2013;Yin et al, 2013;Wang et al, 2014).…”

Influence of interleukin-1β and interleukin-6 gene polymorphisms on the development of acute pancreatitis

“…However, whether polymorphisms of inflammatory cytokines are associated with risk of AP is unknown. Few studies have investigated the association between interleukin gene polymorphism and AP (Chen et al, 2009;Yin et al, 2013). Therefore, we investigated the association between polymorphisms of 2 main proinflammatory cytokines (IL-1b and IL-6) and the risk of AP.…”