Influence of lung function and sleep‐disordered breathing on stroke: a community‐based study

Zhang, J.; Gong, Z.; Li, R.; Gao, Ya; Li, Y.; Li, J.; Yan, Bin; Wang, G.

doi:10.1111/ene.13722

Cited by 13 publications

(11 citation statements)

References 32 publications

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“…The protocol was approved by the Institutional Review Board of each participating institution: Boston University, Case Western Reserve University, Johns Hopkins University, Missouri Breaks Research Inc., New York University Medical Center, University of Arizona, University of California at Davis, University of Minnesota-Clinical and Translational Science Institute, and the University of Washington. The data were accessed on the basis of a signed agreement with the Brigham and Women’s Hospital, Boston, MA, USA [ 31 ].…”

Section: Methodsmentioning

confidence: 99%

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Influence of rapid eye movement sleep on all-cause mortality: a community-based cohort study

Zhang

Jin

et al. 2019

Aging

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Introduction: Although the proportion and duration of rapid eye movement (REM) sleep are correlated with neurological and cardiovascular diseases, whether REM sleep is associated with all-cause mortality in community-based populations remains unknown.Methods: A prospective study was performed within the Sleep Heart Health Study (SHHS, Registration NO. NCT00005275). Total sleep time, sleep efficiency, and REM sleep were measured using polysomnography. Cox proportional hazards regression models were used to estimate the association of the REM sleep with all-cause mortality.Results: Over a mean follow-up period of 11.0 ± 3.1 y, 1234 individuals (21.9%) died. In the entire population, reduced REM sleep was significantly associated with increasing all-cause mortality. After adjustment for age, sex, race, body mass index, smoking status, total cholesterol, triglycerides, high-density lipoprotein, history of diabetes and hypertension, and the apnea–hypopnea index, the duration and proportion of REM sleep were found to be significantly associated with all-cause mortality when the lowest and the highest REM quartile groups were compared (hazard ratio, 95% confidence interval: 1.727, 1.434-2.079; 1.545, 1.298-1.839; respectively).Conclusion: The proportion and duration of REM sleep are negatively associated with all-cause mortality. This finding emphasizes the importance of personalized sleep management in community-based populations.

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Section: Methodsmentioning

confidence: 99%

“…History of diabetes mellitus was ascertained based on the report of a physician-administered diagnosis or on the reported use of insulin or oral hypoglycemic medication. The AHI was defined as the average number of apneas and hypopneas, each associated with a 4% decrease in oxygen saturation per hour of sleep [ 31 ].…”

Section: Methodsmentioning

confidence: 99%

Influence of rapid eye movement sleep on all-cause mortality: a community-based cohort study

Zhang

Jin

et al. 2019

Aging

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“…It has been shown in several studies that a reduction in lung function, particularly in COPD patients, significantly increases the likelihood of the development of both non-fatal ischaemic heart disease and CVD such as heart failure and hypertension [107–109]. Further studies have also shown a relationship between this reduced lung function and both fatal and non-fatal stroke [54,110]. These findings suggest that the increased incidence of stroke outcomes are due to patients having increased blood viscosity and infection susceptibility particularly during an exacerbation [111].…”

Section: Airway Remodelling and Pulmonary Hypertension: Promoters Of Cvdmentioning

confidence: 99%

New frontiers in the treatment of comorbid cardiovascular disease in chronic obstructive pulmonary disease

et al. 2019

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Chronic obstructive pulmonary disease (COPD) is a disease characterised by persistent airflow limitation that is not fully reversible and is currently the fourth leading cause of death globally. It is now well established that cardiovascular-related comorbidities contribute to morbidity and mortality in COPD, with approximately 50% of deaths in COPD patients attributed to a cardiovascular event (e.g. myocardial infarction). Cardiovascular disease (CVD) and COPD share various risk factors including hypertension, sedentarism, smoking and poor diet but the underlying mechanisms have not been fully established. However, there is emerging and compelling experimental and clinical evidence to show that increased oxidative stress causes pulmonary inflammation and that the spill over of pro-inflammatory mediators from the lungs into the systemic circulation drives a persistent systemic inflammatory response that alters blood vessel structure, through vascular remodelling and arterial stiffness resulting in atherosclerosis. In addition, regulation of endothelial-derived vasoactive substances (e.g. nitric oxide (NO)), which control blood vessel tone are altered by oxidative damage of vascular endothelial cells, thus promoting vascular dysfunction, a key driver of CVD. In this review, the detrimental role of oxidative stress in COPD and comorbid CVD are discussed and we propose that targeting oxidant-dependent mechanisms represents a novel strategy in the treatment of COPD-associated CVD.

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“…Neck circumference (NC), which is correlated with the distribution of upper body subcutaneous adipose tissue, is also an anthropometric marker used to identify overweight and obese individuals. 8 A previous study demonstrated that NC positively correlated with BMI and WC. 9 In addition, NC was found to be more similar to visceral fat, which is more closely related to cardiovascular risk than subcutaneous fat.…”

Section: Introductionmentioning

confidence: 91%

<p>Neck Circumference is Associated with Incidence of Angina Pectoris in a Large Community-Based Population</p>

Yan

Zhao

et al. 2020

DMSO

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Background: Previous studies have found that neck circumference (NC) is associated with cardiovascular disease risk factors. This study investigated the relationship between NC and the incidence of angina pectoris (AP). Methods: Altogether 4821 participants (2212 males and 2609 females) from the Sleep Heart Health Study (SHHS) with a mean age of 63.4±11.0 years were selected in this study. Anthropometric measurements, including NC, waist circumference (WC), hip circumference (HC), and body mass index (BMI), were collected at baseline. AP was defined as the first occurrence between baseline and 2011. Linear and logistic regression analysis was used to explore the association between NC and incidences of AP. Results: There was a significant difference in NC between AP and controls in both male (41.1±3.1 cm vs 40.3±3.2 cm; p<0.001) and female (35.2±3.1 cm vs 34.9±2.9 cm; p=0.006). Multivariable linear regression analysis showed that NC (every cm increase) was independently associated with the incidence of AP in both male (odds ratio [OR] 1.067; 95% confidence interval [CI] 1.035-1.100; p<0.001) and female (OR 1.067; 95% CI 1.035-1.101; p<0.001). Conclusion: NC was significantly associated with the incidence of AP in both male and female. The role of NC in the incidence of AP is worthy of further investigation.

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Influence of lung function and sleep‐disordered breathing on stroke: a community‐based study

Abstract: Lung function may serve as a risk factor for incident stroke in a community-based population, especially in those with SDB. Spirometry may help improve the risk management for primary care in community-based populations.

Cited by 13 publications

References 32 publications

Influence of rapid eye movement sleep on all-cause mortality: a community-based cohort study

Influence of rapid eye movement sleep on all-cause mortality: a community-based cohort study

New frontiers in the treatment of comorbid cardiovascular disease in chronic obstructive pulmonary disease

<p>Neck Circumference is Associated with Incidence of Angina Pectoris in a Large Community-Based Population</p>

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