Influence of meteorological parameters in the seasonality of influenza viruses circulating in Northern Cameroon

Njifon, Hermann Landry Munshili; Monamele, Chavely Gwladys; Kengne‐Nde, Cyprien; Vernet, Marie‐Astrid; Gaké, Bouba; Tchatchouang, Serges; Njankouo, Mohamadou Ripa; Tapondjou, Raphaël; Deweerdt, Louis; Mbacham, Wilfred; Njouom, Richard

doi:10.1111/irv.12612

Cited by 9 publications

(7 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…32 Associations of respiratory viral activity with temperature are often not observed in tropical and subtropical settings, and of meteorological parameters, relative humidity is most often correlated with respiratory viral activity in the literature. [33][34][35] As with seasonality, associations between meteorological parameters and respiratory viral activity may vary by subregion within a country in tropical and subtropical settings.…”

Section: Discussionmentioning

confidence: 99%

Respiratory Viral Infection: An Underappreciated Cause of Acute Febrile Illness Admissions in Southern Sri Lanka

Tillekeratne

Bodinayake

Simmons³

et al. 2019

The American Journal of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

The contribution of respiratory viruses to acute febrile illness (AFI) burden is poorly characterized. We describe the prevalence, seasonality, and clinical features of respiratory viral infection among AFI admissions in Sri Lanka. We enrolled AFI patients ³ 1 year of age admitted to a tertiary care hospital in southern Sri Lanka, June 2012-October 2014. We collected epidemiologic/clinical data and a nasal or nasopharyngeal sample that was tested using polymerase chain reaction (Luminex NxTAG, Austin, TX). We determined associations between weather data and respiratory viral activity using the Spearman correlation and assessed respiratory virus seasonality using a Program for Appropriate Technology definition. Bivariable and multivariable regression analyses were conducted to identify features associated with respiratory virus detection. Among 964 patients, median age was 26.2 years (interquartile range 14.6-39.9) and 646 (67.0%) were male. One-fifth (203, 21.1%) had respiratory virus detected: 13.9% influenza, 1.4% human enterovirus/ rhinovirus, 1.4% parainfluenza virus, 1.1% respiratory syncytial virus, and 1.1% human metapneumovirus. Patients with respiratory virus identified were younger (median 9.8 versus 27.7 years, P < 0.001) and more likely to have respiratory signs and symptoms. Influenza A and respiratory viral activity peaked in February-June each year. Maximum daily temperature was associated with influenza and respiratory viral activity (P = 0.03 each). Patients with respiratory virus were as likely as others to be prescribed antibiotics (55.2% versus 52.6%, P = 0.51), and none reported prior influenza vaccination. Respiratory viral infection was a common cause of AFI. Improved access to vaccines and respiratory diagnostics may help reduce disease burden and inappropriate antibiotic use.

show abstract

Section: Discussionmentioning

confidence: 99%

Respiratory Viral Infection: An Underappreciated Cause of Acute Febrile Illness Admissions in Southern Sri Lanka

Tillekeratne

Bodinayake

Simmons³

et al. 2019

The American Journal of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

show abstract

“…Respiratory samples were collected between January 2014 and June 2016 from outpatients with clinical evidence of influenza‐like illness (ILI), defined as sudden onset of fever≥38°C and cough or sore throat within the past 5 days. These samples were collected at six sentinel sites involved in influenza surveillance in the Northern region of Cameroon as schematically illustrated by Munshili Njifon et al elsewhere . Nasopharyngeal swabs were introduced into a cryotube containing 2ml of virus transport medium and stored at +4°C at the study sites before being transported to the National Influenza Centre (NIC) at Centre Pasteur of Cameroon where analyses were performed.…”

Section: Methodsmentioning

confidence: 99%

“…A previous study performed molecular characterization of influenza A(H3N2) from sentinel sites in the Southern regions of Cameroon and confirmed the progressing evolution of influenza A(H3N2) viruses in Cameroon. We report here the genome characterization of influenza A(H3N2) from the Northern region of Cameroon characterized by a Sudan tropical climate, with high temperatures …”

Section: Introductionmentioning

confidence: 99%

Genetic diversity of influenza A(H3N2) viruses in Northern Cameroon during the 2014‐2016 influenza seasons

Njifon

Monamele

Vernet

et al. 2019

Journal of Medical Virology

Self Cite

View full text Add to dashboard Cite

In Cameroon, genome characterization of influenza virus has been performed only in the Southern regions meanwhile genetic diversity of this virus varies with respect to locality. The Northern region characterized by a Sudan tropical climate might have distinct genetic characterization. This study aimed to better understand the genetic diversity of influenza A(H3N2) viruses circulating in Northern Cameroon. Sequences of three gene segments (hemagglutinin (HA), neuraminidase (NA) and matrix (M) genes) were obtained from 16 A(H3N2) virus strains collected during the 2014 to 2016 influenza seasons in Garoua. The HA gene segments were analysed with respect to reference strains while the NA and M gene was analysed for reported genetic markers of resistance to antivirals. Analysis of the HA sequences revealed that majority of the virus strains grouped together with the 2016‐2017 vaccine strain (3C.2a‐A/Hong Kong/4801/2014) while 3/5 (60%) of the 2015 viral strains grouped together with the 2015‐2016 vaccine strain 3C.3a‐A/Switzerland/9715293/2013. Within clade 3C.2a, Northern Cameroon sequences mostly grouped in sub‐clade A3 (10/16). Analysis of the coding regions of the NA and M genes showed that none had genetic markers of resistance to neuraminidase inhibitors but all strains possessed the S31N substitution of resistance to amantadine. Due to some discrepancies observed in this region with respect to the Southern regions of Cameroon, there is necessity of including all regions within a country in the sentinel surveillance of influenza. These data will enable to track changes in influenza viruses in Cameroon.

show abstract

“…The copyright holder for this preprint this version posted July 4, 2020. ; https://doi.org/10.1101/2020.07.02.20145250 doi: medRxiv preprint III circulating viruses 32 . Here, we focus on providing a framework for forecasting future trends, which could be invaluable for public health planning and response.…”

Section: Introductionmentioning

confidence: 99%

Nowcasting Influenza-like Illness Trends in Cameroon

Nsoesie

Oladeji

Abah

et al. 2020

Preprint

View full text Add to dashboard Cite

Although acute respiratory infections are a leading cause of mortality in sub-Saharan Africa, surveillance of diseases such as influenza is mostly neglected. Evaluating the usefulness of influenza-like illness (ILI) surveillance systems and developing approaches for forecasting future trends is important for pandemic preparedness. We applied statistical and machine learning models to forecast 2012 to 2018 trends in ILI cases reported by the Cameroon Ministry of Health (MOH), using Google searches for influenza symptoms, treatments, natural or traditional remedies as well as, infectious diseases with a high burden (i.e., AIDS, malaria, tuberculosis). The variance explained by the models based on Google search data were 87.7%, 79.1% and 52.0% for the whole country, the Littoral and Centre regions respectively. Our study demonstrates the need for developing contextualized approaches when using digital data for disease surveillance and demonstrates the potential usefulness of search data for monitoring ILI in sub-Saharan African countries.

show abstract

Influence of meteorological parameters in the seasonality of influenza viruses circulating in Northern Cameroon

Cited by 9 publications

References 24 publications

Respiratory Viral Infection: An Underappreciated Cause of Acute Febrile Illness Admissions in Southern Sri Lanka

Respiratory Viral Infection: An Underappreciated Cause of Acute Febrile Illness Admissions in Southern Sri Lanka

Genetic diversity of influenza A(H3N2) viruses in Northern Cameroon during the 2014‐2016 influenza seasons

Nowcasting Influenza-like Illness Trends in Cameroon

Contact Info

Product

Resources

About