2020
DOI: 10.1186/s12872-020-01437-w
|View full text |Cite
|
Sign up to set email alerts
|

Influence of microcirculation load on FFR in coronary artery stenosis model

Abstract: Background: The coronary artery hemodynamics are impacted by both the macrocirculation and microcirculation. Whether microcirculation load impact the functional assessment of a coronary artery stenosis is unknown. The purpose of this study is to investigate the effect of porous media of the microcirculation on fractional flow reserve (FFR) in stenotic coronary artery model. Methods: A three dimensional computational simulation of blood flow in coronary artery symmetric stenotic model was constructed. The compu… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

0
6
0

Year Published

2021
2021
2025
2025

Publication Types

Select...
6
1

Relationship

1
6

Authors

Journals

citations
Cited by 10 publications
(6 citation statements)
references
References 36 publications
0
6
0
Order By: Relevance
“…However, free outlet and constant load outlet do not meet the physiological requirements, and microcirculation load outlet condition can better simulate the physiology situation. In our another study, the porous media of the microcirculation is shown to play a important role in the FFR calculation [7].…”
Section: Discussionmentioning
confidence: 89%
See 2 more Smart Citations
“…However, free outlet and constant load outlet do not meet the physiological requirements, and microcirculation load outlet condition can better simulate the physiology situation. In our another study, the porous media of the microcirculation is shown to play a important role in the FFR calculation [7].…”
Section: Discussionmentioning
confidence: 89%
“…And now FFR is regarded as a gold-standard test for myocardial ischemia. FFR is impacted by multi-factor such as artery stenosis and microcirculation impedance [7]. The impact of CT on FFR was not studied previously.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Finally, macrovascular and microvascular diseases can affect coronary physiology after PCI. Evidence suggests that microvascular dysfunctions may falsify the results of FFR and be associated with adverse events after PCI (32)(33)(34). We will perform experimental and computational analyses of post-PCI microvascular dysfunction in future studies to quantify this effect.…”
Section: Limitationsmentioning
confidence: 99%
“…However, the results derived from pressure-wire-based assessments are lesion-based parameters, which do not represent information on the size of the perfused area exposed to ischemia due to stenosis, and it is thought that they do not reflect the microcirculatory condition (15). A recent study showed that FFR is slightly increased during the presentation of microcirculation dysfunction (16).…”
Section: Epicardial Artery and Microcirculationmentioning
confidence: 99%