Influence of Moderately Elevated Levels of Carboxyhemoglobin on the Course of Acute Ischemic Heart Disease

Abstract

The purpose of this prospective study in 66 patients with acute ischemic heart disease was to analyze the possible effects of moderately elevated levels of carboxyhemoglobin (COHb) on the early course of this disease. Thirty-one patients presented with a level of COHb ≤2% and 35 with a level of > 2%. In the group with elevated COHb, more patients developed transmural infarction, but the difference was not significant (p = 0.123). Patients with transmural infarction had higher maximum CPK values (p < 0.01), when COHb levels were > 2%. During the first 6 h after admission to hospital, these patients needed an antiarrhythmic treatment significantly more frequently (p = 0.003). Differences in rhythm disorders were still present at a time when nicotine, due to its short biological half-life, was already eliminated. We conclude that a moderately elevated level of COHb is not just a marker for recent smoking but may aggravate the course of acute ischemic heart disease.

Nicotine Ingestion Reduces Heart Rate Variability in Young Healthy Adults

“…Many researches have done earlier in smoking subjects found that NRT in smoking cessation have no significant disturbances of autonomic cardiac control (including heart rate, systolic blood pressure, hematologic and coagulation indices, and CO level) when compared with smoking event in smokers [ 20 – 23 ]. However, this did not mean NRT is safe.…”

“…Over time, excessive energy demands on the system Note: data was presented as mean ± SEM; "F" meant female, "M" meant male; LF and HF measurements were in normalized unit; only P value < 0.05 was annotated. Many researches have done earlier in smoking subjects found that NRT in smoking cessation have no significant disturbances of autonomic cardiac control (including heart rate, systolic blood pressure, hematologic and coagulation indices, and CO level) when compared with smoking event in smokers [20][21][22][23]. However, this did not mean NRT is safe.…”

Cardiovascular Adverse Events Associated with Smoking-Cessation Pharmacotherapies

“…In a single blind, crossover, placebocontrolled study, high-dose nicotine patch along with cigarette smoking had no additional adverse effects on heart rate, blood pressure, fibrinogen levels, or lipid profiles in long-term smokers [14]. The probable explanation is the development of tolerance to nicotine and hence minimal CVD events in long-term smokers who received NRT [15,21,22].…”

Do carboxyhemoglobin and methemoglobin levels predict the return of spontaneous circulation and prognosis of cardiac arrest patients?

“…The reported blood COHb level is approximately 1.0% in non-smokers and 5.5% in patients with a smoking history (10). In some studies, it has been reported that high and low COHb levels are associated with poor clinical prognosis in various pathological conditions, including pulmonary embolism (PTE), acute ischemic heart disease, and critically ill patients in intensive care units (ICU) (11)(12)(13).…”