Influence of New Polyphenol Compound From Euphorbia Plant on Mitochondrial Function

Gayibov, Ulugbek

doi:10.15414/jmbfs.2019.8.4.1021-1025

Cited by 6 publications

(4 citation statements)

References 23 publications

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“…According to the literature data, polyphenols, especially condensable and hydrolysable tannins, exhibit higher antioxidant properties than flavonoids [17][18][19].…”

Section: Resultsmentioning

confidence: 99%

Effect of Polyphenols Isolated from Plantago major L. and Plantago lanceolata L. on Mitochondrial Permeability Transition Pore in Rat Liver

Ergashev,

Sayfieva,

Makhmudov

et al. 2024

Trends Sci

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It has been shown that the transport of electrons in the respiratory chain of mitochondria, ion-transport processes, the balance of Ca2+ ions and other metabolic processes in the cell are intrinsically connected with lipoperoxidation processes. In particular, in recent years, plant biologically active compounds have been widely used to eliminate oxidative processes developing in the body. Accordingly, we considered it important to study the mechanisms of action of xylopyr-T, glucopyr-T and 2-DVG polyphenols isolated from the plants Plantago major L. and Plantago lanceolata L., belonging to the Plantaginaceae family, which are widely used in folk medicine. Therefore, in vitro experiments, the amount of malondialdehyde and the condition state of mPTP were studied by spectrophotometric method. The obtained results revealed that the studied polyphenols inhibit lipoperoxidation induced by Fe2+/ascorbate the production of malondialdehyde was reduce by xylopyr-T to 81.9 ± 1.2 %, by glucopyr-T to 79.4 ± 1.7 % and by 2-DVG to 75.0 ± 1.8 % at a concentration of 4 µM in rat liver mitochondria. At the same time, mPTP opening in the medium with the substrate succinate (+ rotenone) inhibition 2-DVG polyphenol at a concentration of 100 μM was reduced by 84.5 ± 2.8 %, xylopyr-T polyphenol at a concentration of 200 μM by 67.6 ± 4.8 % and it was shown that glucopyr-T polyphenol at a concentration of 200 µM by 32.5 ± 1.65 % compared to the control. In conclusion, it can be illustrated that the studied polyphenols, along with their high antioxidant properties, show a structure-dependent inhibition of mPTP opening, which is involved in various physiological and pathological processes. HIGHLIGHTS In this study, hydrolysable tannins, which have strong antioxidant properties isolated from Plantago plants, were investigated and confirmed by MDA analysis in vitro These hydrolyzable tannins exhibited substrate-dependent inhibition of rat liver mitochondrial PTP in vitro It can be assumed from the data obtained that these hydrolyzable tannins act organ-specifically GRAPHICAL ABSTRACT

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“…According to the literature data, polyphenols, especially condensable and hydrolysable tannins, exhibit higher antioxidant properties than flavonoids [17][18][19].…”

Section: Resultsmentioning

confidence: 99%

Effect of Polyphenols Isolated from Plantago major L. and Plantago lanceolata L. on Mitochondrial Permeability Transition Pore in Rat Liver

Ergashev,

Sayfieva,

Makhmudov

et al. 2024

Trends Sci

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“…Napellin-type diterpene alkaloids and their aromatic ester-free derivatives exhibit weak spasmolytic activity, while its derivative 1-Obenzoylnapelline has spasmolytic activity (Dzhakhangirov et al 2013). The high antioxidant/antiradical activity of polyphenol compounds has also been studied (Gayibov et al 2019).…”

Section: Resultsmentioning

confidence: 99%

Effect of diterpene alkaloids on lipid peroxidation in mitochondria

Muratova

Ergashev

Sobirov

et al. 2021

Nova Biotechnol. Chim.

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In this article, the antioxidant activity of some alkaloids lipid peroxidation (LPO) in rat liver mitochondria has been studied. It has been established that diterpenoid alkaloids: 1-О-benzoylnapelline, napelline and songorine have a protective effect on mitochondria, reducing the damaging effect of Fe2+/ascorbate and the release of malondialdehyde (MDA) into the secondary products of peroxidation. The effect of alkaloids napelline, 1-O-benzoylnapelline and songorine on the processes of MDA formation in rat liver mitochondria in vitro has been studied.Where in at 200 мM concentrations, 1-О-benzoylnapelline inhibited the formation of MDA by 95 %, and the alkaloids napelline and songorine at this concentration inhibited the formation of MDA by 54 and 44 %. From the data obtained, it can be shown that 1-О-benzoylnapelline strongly inhibits the formation of MDA compared to songorine and napelline.

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“…In the literature, antioxidant polyphenols are associated with both their ability to chelate various metal ions (Mierzliak et al, 2014) and directly interact with reactive oxygen species: O2 • (Pietta, 2000), OH radicals and singlet oxygen (Parker, 2001). Also, polyphenols can interact and/or bind the components of the reaction medium (Gayibov et al, 2019), which can lead to distorted results. The use of the method with MDA or Fe 2+ /ascorbate-induced POL is not possible to directly assess the contribution of each of these effects to the total antioxidant activity of drugs (Gayibov et al, 2018).…”

Section: The Antiradical Activity Of the Gossitanmentioning

confidence: 99%

Physiological Alterations of Mitochondria Under Diabetes Condition and Its Correction by Polyphenol Gossitan

Pozilov¹,

Gayibov²,

Asrarov³

et al. 2022

J microb biotech food sci

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The state of lipid peroxidation (LPO), respiration and oxidative phosphorylation, mitochondrial permeability transition pore (mPTP) and antiradical activity of rat liver mitochondria in streptozotocin (STZ)-induced diabetes condition were studied, considered the ways of correction of detected membrane damages with the use of gossitan, isolated from cotton plant Gossypium hirsutum L. It was shown that the rate of respiration of liver mitochondria in states V3 and V4 increases during STZ-induced diabetes, which significantly reduces the respiratory control (RC) and ADP/O coefficients in comparison with the control. The findings suggest that the uncoupling of respiration and oxidative phosphorylation takes place during STZ-induced diabetes. It was shown that in the conditions of STZ-induced diabetes, the rate of swelling of rat liver mitochondria is higher than of the healthy ones; this means that mPTP of rat liver mitochondria is in the open state. Gossitan recovers mPTP to the normal condition, thereby removing the effect of STZ on mitochondria. Gossitan (per os dose is 10 mg/kg of body weight, during 8 days) eliminates the detected functional disorders of rat liver mitochondria, probably due to its antioxidant properties.

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Influence of New Polyphenol Compound From Euphorbia Plant on Mitochondrial Function

Abstract: Institute of Bioorganic chemistry named after acad. A

Cited by 6 publications

References 23 publications

Effect of Polyphenols Isolated from Plantago major L. and Plantago lanceolata L. on Mitochondrial Permeability Transition Pore in Rat Liver

Effect of Polyphenols Isolated from Plantago major L. and Plantago lanceolata L. on Mitochondrial Permeability Transition Pore in Rat Liver

Effect of diterpene alkaloids on lipid peroxidation in mitochondria

Physiological Alterations of Mitochondria Under Diabetes Condition and Its Correction by Polyphenol Gossitan

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