Influence of nutrients involved in one-carbon metabolism on DNA methylation in adults—a systematic review and meta-analysis

Amenyah, Sophia; Hughes, Catherine F; Ward, Mary; Rosborough, Samuel; Deane, Jennifer; Thursby, Sara Jayne; Walsh, Colum P.; Kok, Dieuwertje E.; Strain, James J.; McNulty, Helene; Lees-Murdock, Diane J.

doi:10.1093/nutrit/nuz094

Cited by 35 publications

(27 citation statements)

References 82 publications

(138 reference statements)

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“…For instance, they can work as co-factors of essential enzymes for growth, immune responses and energy expenditure [16]. Key micronutrients associated with growth performance are vitamin B6, vitamin B12 and folate (vitamin B9) [17] that together comprise part of the one-carbon (1C) nutrients [18]. In contrast to other micronutrients, 1C nutrients showed significant influence on growth performance in zebrafish [17] and salmon [12][13][14][15] feeding trials.…”

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confidence: 99%

Micronutrient supplementation affects transcriptional and epigenetic regulation of lipid metabolism in a dose-dependent manner

et al. 2020

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Micronutrients (vitamins and minerals) have been less well studied compared to macronutrients (fats, proteins, and carbohydrates) although they play important roles in growth, metabolism, and maintenance of tissues. Hence, there is growing interest to understand the influence of micronutrients across various aspects in nutritional research. In the last two decades, aquaculture feeds have been shifted to containing more plant-based materials to meet the increasing demand and maintain the sustainability in the industry. A recent whole life cycle feeding trial of Atlantic salmon ( Salmo salar ) with graded levels of micronutrient packages has concluded that the levels of several B-vitamins and microminerals need to be increased from the current recommendation levels for optimal growth and fish welfare when plant-based diets are used. Here, we show the effect of micronutrient supplementation on hepatic transcriptional and epigenetic regulation in a dose dependent manner. . Specifically, our aim is to reveal the mechanisms of altered cell metabolism, which results in improved growth performance by micronutrient surpluses, at gene expression and DNA methylation levels. Our results strongly indicate that micronutrient supplementation suppresses gene expression in lipid metabolism in a dose-dependent manner and broadly affects DNA methylation in cell-adhesion and cell-signalling. In particular, it increases DNA methylation levels on the acetyl-CoA carboxylase alpha promoter in a concentration-dependent manner, which further suggests that acetyl-CoA carboxylase alpha is an upstream epigenetic regulator controlling its downstream lipid biosynthesis activities. This study demonstrates a comprehensive analysis to reveal an important role of micronutrients in lipid metabolism through epigenetic control of gene expression.

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confidence: 99%

Micronutrient supplementation affects transcriptional and epigenetic regulation of lipid metabolism in a dose-dependent manner

et al. 2020

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“…Folate is an important micronutrient involved in 1‐carbon metabolism and DNA methylation, required for the formation of the neural tube during embryonic development (Amenyah et al, ). Common sources of folate in the United States are natural foods, multivitamin or folic acid supplement pills, and enriched cereal grain products and breakfast cereals with folic acid.…”

Section: Discussionmentioning

confidence: 99%

Association between body mass index and folate insufficiency indicative of neural tube defects risk among nonpregnant women of childbearing age in the United States, NHANES, 2007–2010

Manandhar

Beydoun

Kancherla

2020

Birth Defects Research

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Background: Maternal folate status and obesity are known risk factors for neural tube defects (NTD) in the offspring. We examined the association between body mass index (BMI) categories and blood folate concentrations, specifically, red blood cell (RBC) folate concentrations indicative of NTD risk among nonpregnant women of child-bearing age (20-44 years) in the United States. Methods: We used data from 2007 to 2010 US National Health and Nutrition Examination Survey (NHANES). Overweight, obesity, and strata within obesity were examined. Serum and RBC folate concentrations were examined as continuous and categorical variables. RBC folate concentrations were grouped indicating high (≤585 nmol/L) and elevated risk (586-747 nmol/L) for NTDs.Unadjusted and adjusted prevalence odds ratios (aPOR) and their 95% confidence intervals (CI) were estimated using logistic regression.Results: Of the 30,878 participants, 25.6% were overweight, 32.7% obese, and 32.3% had RBC folate concentration indicating NTD risk (<748 nmol/L). Overweight was not associated with RBC folate level for NTD risk; however, a marginally significant negative association was noted for overall obesity and RBC folate concentrations indicative of elevated NTD risk (aPOR = 0.76; 95% CI = 0.45, 1.00). A significant protective association was noted between Class 3 obesity (BMI ≥40 kg/m 2 ) and folate concentration indicative of high NTD risk (≤585 nmol/L; aPOR = 0.46; 95% CI = 0.24, 0.89). Conclusions:The prevalence of RBC folate concentrations indicating elevated or high NTD risk varied by level of obesity among nonpregnant women of child-bearing age. Further studies are needed to understand the folate pathway in overweight and obese women and subsequent NTD risk in their offspring. K E Y W O R D Sanencephaly, body mass index, folate, folic acid, neural tube defects, prevention, spina bifida

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“…The study design utilized as well as dietary or biochemical data collected are critical when investigating the link between nutrient intake or status and DNA methylation. The majority of studies so far are observational and have provided inconsistent evidence for the role of dietary factors, especially B-vitamins, in modulating DNA methylation, perhaps owing to inconsistencies in study design and choice of assay ( 101 ). Although observational studies offer the advantage of providing comprehensive data with large sample sizes and highlight associations between nutrients and DNA methylation, they are unable to provide clarity with respect to dietary causality.…”

Section: Methodological Aspects Of Studies Investigating Dna Methylatmentioning

confidence: 99%

Nutritional Epigenomics and Age-Related Disease

Amenyah

Ward

Strain

et al. 2020

Current Developments in Nutrition

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Abstract Recent advances in epigenetic research have enabled the development of epigenetic clocks, which have greatly enhanced our ability to investigate molecular processes that contribute to aging and age-related disease. These biomarkers offer the potential to measure the effect of environmental exposures linked to dynamic changes in DNA methylation, including nutrients, as factors in age-related disease. They also offer a compelling insight into how imbalances in the supply of nutrients, particularly B-vitamins, or polymorphisms in regulatory enzymes involved in 1-carbon metabolism, the key pathway that supplies methyl groups for epigenetic reactions, may influence epigenetic age and interindividual disease susceptibility. Evidence from recent studies is critically reviewed, focusing on the significant contribution of the epigenetic clock to nutritional epigenomics and its impact on health outcomes and age-related disease. Further longitudinal studies and randomized nutritional interventions are required to advance the field.

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Influence of nutrients involved in one-carbon metabolism on DNA methylation in adults—a systematic review and meta-analysis

Cited by 35 publications

References 82 publications

Micronutrient supplementation affects transcriptional and epigenetic regulation of lipid metabolism in a dose-dependent manner

Micronutrient supplementation affects transcriptional and epigenetic regulation of lipid metabolism in a dose-dependent manner

Association between body mass index and folate insufficiency indicative of neural tube defects risk among nonpregnant women of childbearing age in the United States, NHANES, 2007–2010

Nutritional Epigenomics and Age-Related Disease

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