Influence of Postural Changes on the Glomerular Filtration Rate in Nephroptosis

Bianchi, Cesare; Bonadio, M.; Andriole, Vincent T.

doi:10.1159/000180598

Cited by 15 publications

(8 citation statements)

References 11 publications

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“…In this respect, the studies of McCann and Romansky [12] and Bianchi el al. [1] disagree with our observations. McCann and Romansky [12] found an inconstant change in GFR in as well nephroptotic as non-nephroptotic hyperten sives and normotensives.…”

Section: Discussioncontrasting

confidence: 99%

“…Bianchi el al. [1] re cently reported a significant decrease of GFR in nephroptotic patients (11 normotensives and 1 hypertensive), and no change in his controls (5 normotensives). The explanation for this inconsistency in the results is most likely due to the different approach to the prob lem.…”

Section: Discussionmentioning

confidence: 97%

“…Whether postural changes have the same effect on the glomerular filtra tion remains questionable. Studies reporting an orthostatic decrease in glomerular filtration rate (GFR) [2,8,13] were opposed by others [1,12], who found a relative constancy of GFR values in upright and recumbent posi tion. McCann and Romansky [12] and Bianchi et al [1] disagree about the effect of nephro ptosis on the glomerular filtration.…”

Section: Introductionmentioning

confidence: 99%

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Nephroptosis and Kidney Function

Donker¹,

Vanherk²,

Kremer³

et al. 1978

Nephron

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We have investigated the influence of renal mobility on both renal blood flow and glomerular filtration, in order to evaluate its role as a potential intermediate cause of hypertension. In 25 untreated patients we compared between recumbent and upright position the relative change in the following five parameters: effective renal plasma flow (ERPF), glomerular filtration rate (GFR), renal mobility, peripheral plasma renin activity (PRA) and blood pressure. We found a positive correlation between the degree of renal mobility and an observed decrease in ERPF. On the other hand, no relation was found between the former and an observed decrease in GFR. The PRA appeared to rise following the decrease of the ERPF. These observations suggest that renal mobility adds to the orthostatic reduction in renal blood flow.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

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Nephroptosis and Kidney Function

Donker¹,

Vanherk²,

Kremer³

et al. 1978

Nephron

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“…As a consequence, no quantitative assessment can be made, nor the detection of a bilateral displacement of both kidneys by the same extent can be obtained. However, bilateral RM has been reported to be present only in 20% of the subjects with nephroptosis [4]; the probability of missing cases with an equal degree of left and right kidney mobility seems thus to be low.…”

Section: Discussionmentioning

confidence: 91%

Arterial Blood Pressure and the Renin-Angiotensin-Aldosterone System during Postural Changes in Hypertensive Patients with Unilateral Renal Mobility

Fommei¹,

Palla²,

Gazzetti³

et al. 1985

Nephron

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Unilateral renal mobility was identified in 27 out of 100 essential hypertensive patients by examination of renal scintiphotos. The pattern of response to postural changes of blood pressure (BP), plasma renin activity (PRA) and plasma aldosterone concentration (PAC) was investigated in 11 patients with renal mobility and without treatment and compared with that of an age- and sex-matched group of untreated hypertensives without renal mobility. The patients with renal mobility had higher BP levels (X ± SD mm Hg: supine 185 ± 39/112 ± 18 vs. 149 ± 18/97 ± 14; upright 167 ± 38/108 ± 17 vs. 144 ± 7/93 ± 10; p < 0.05). Significant correlations were obtained in the patients with renal mobility (but not in those without renal mobility) between upright PRA and PAC (p < 0.001), their postural variations (p < 0.01) and between upright PRA (and PAC) and BP levels (p < 0.05). The high prevalence of renal mobility in hypertension and the relationship observed between the activated renin-angiotensin-aldosterone system and BP in this condition suggest the importance of searching for unilateral renal mobility when examining the renin-angiotensin-aldosterone system in hypertensive patients, particularly during postural manoeuvres.

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“…Due to these considerations, I think that ‘nephroptosis’ or ‘floating kidney’ should be added to complete the list of urological causes of hematuria; even if this is only correct in the early stages of the disease because over a longer time it would be more correct to place this kind of hematuria among the nephrological causes [18]. …”

Section: Introductionmentioning

confidence: 99%

Hematuria in Nephroptosis

Boccardo¹

1998

Nephron

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Influence of Postural Changes on the Glomerular Filtration Rate in Nephroptosis

Cited by 15 publications

References 11 publications

Nephroptosis and Kidney Function

Nephroptosis and Kidney Function

Arterial Blood Pressure and the Renin-Angiotensin-Aldosterone System during Postural Changes in Hypertensive Patients with Unilateral Renal Mobility

Hematuria in Nephroptosis

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