Influence of shape and surface properties of microstructured reaction areas on the deposition of silica

Helmecke, Olaf; Menneking, Christin; Behrens, Peter; Menzel, Henning

doi:10.1007/s00396-007-1743-4

Cited by 5 publications

(8 citation statements)

References 26 publications

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“…In previous investigations [9,10], we used photochemically grafted polymers [50,51], in a laterally structured way to obtain differently shaped microarrays covered with hydrophilic polymers surrounded by a hydrophobic poly(acrylic acid 2-ethyl-hexylester) (PEHAA) layer. These structures-hexagons, pentagons, squares, and stripes-can be prepared in different sizes (see Figs.…”

Section: Resultsmentioning

confidence: 99%

“…[10] using poly(acrylic acid 2-ethyl-hexylester) as the first polymer and branched poly-(ethylene imine) as the second polymer.…”

Section: Preparation Of Patterned Polymer Filmsmentioning

confidence: 99%

“…In this paper we describe the use of previously reported grafting methods for fabrication of patterned areas, which can be used for silica deposition experiments [9,10]. These patterns represent a model compartment for silification reactions as present at the SDV.…”

Section: Introductionmentioning

confidence: 98%

“…In another example, areas 10 µm in diameter of poly(2-(dimethylamino)ethyl methacrylate), created by graft polymerization on a surface, were exposed to a silicic acid solution, resulting in the formation of silica within the swollen polymer film [7,8]. In a previous study, we have investigated whether the shape and dimensions of thin polymer film areas on a surface can influence silica formation [9,10]. These areas were prepared by photochemical grafting of poly(acrylic acid 2-ethylhexyl ester) and poly(ethyleneimine) (or another hydrophilic polymer) onto different regions of silicon surfaces.…”

Section: Introductionmentioning

confidence: 99%

“…These two polymers differ strongly in their wetting behavior. When they were used in silica deposition experiments, it was realized that the shape and dimensions of the reactive areas have only a slight influence on silica formation, while the presence of a hydrophilic polymer on the surface of the reaction area is the most important parameter for the silica deposition [10].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Influence of polymeric additives on biomimetic silica deposition on patterned microstructures

Helmecke

Hirsch

Behrens

et al. 2008

Journal of Colloid and Interface Science

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Section: Resultsmentioning

confidence: 99%

“…[10] using poly(acrylic acid 2-ethyl-hexylester) as the first polymer and branched poly-(ethylene imine) as the second polymer.…”

Section: Preparation Of Patterned Polymer Filmsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Influence of polymeric additives on biomimetic silica deposition on patterned microstructures

Helmecke

Hirsch

Behrens

et al. 2008

Journal of Colloid and Interface Science

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Fibroblast growth on patterned polymeric coatings

Genzel

Sen-Richter

Reich

et al. 2015

Physica Status Solidi (a)

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Cochlear implantation enables many patients to hear again after severe to profound sensorineural hearing loss. Despite great success there is huge variability in outcome between patients. One of the reasons for this might be the interface between stimulating electrode and surrounding tissue. Fibrous tissue is formed around the electrode array after implantation and causes an increase in electrical impedance. Currently there are several approaches under investigation to address this issue. Amongst them are surface coatings but also surface patterning. The aim of the current study was therefore to investigate a number of polymeric coatings for their ability to reduce fibroblast growth and to investigate the influence of patterned surface coating on cell growth in vitro. Polymers were attached to the surface by the grafting onto method using a photoreactive anchor layer. Patterns (parallel polymer lines of different dimensions) were generated by selectively cross‐linking the polymer to the anchor molecules on the surface followed by removal of any excess polymer. EGFP producing fibroblasts were seeded on the surface and their growth was documented every day until complete coverage was achieved. A reduction in cell growth was observed for poly(ethyloxazoline) (PEtOx) and poly(dimethylacryl‐amide) (PDMAA) with only PDMAA resulting in coverage with cells of less than 25% indicating nearly complete growth inhibition when seeded on areas completely covered by polymer. Polymer lines of 5 μm width separated by 50 μm did not show a large influence on cell growth whereas lines of 12, 24, or 48 μm width separated by 50 μm had an influence on cell growth especially for PDMAA and PEtOx. This influence was most apparent on days 2 and 3 after seeding and vanished between days 4 and 7 depending on polymer and pattern. It was possible to suppress fibroblast growth on the surface by using polymeric coatings but a partial coating in the dimension used in the current study affected cell growth only for up to 1 week and would not be sufficient to reduce fibroblast growth permanently after implantation.

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