“…20 However, the significantly higher glucose concentrations recorded during certain collection times in P3 compared with P2 were likely caused by use of an a2 agonist, xylazine, in the P3 anesthetic protocol, as this agonist is known to cause hypoinsulinemia and increases in blood glucose concentrations. 21,22 Increased TP and albumin concentrations during physical restraint previously have been attributed to hemoconcentration. 11 Decreases in these concentrations during anesthesia could be related to alterations in capillary permeability caused by the anesthetic agents, resulting in a certain degree of hemodilution and protein loss, especially albumin loss.…”