Influence of some spice food based bioproducts on human monocytic cells line type THP-1

Radu, Nicoleta; Roman, Viviana; Bostan, Marinela; Radu, Elena; Tănăsescu, Ciprian

doi:10.1080/15421406.2017.1361307

Cited by 8 publications

(3 citation statements)

References 13 publications

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“…The sterile supernatant, called postbiotic, was used to supplement the culture medium of Caco-2-type tumor cells. Proliferation studies were performed in microplates with 96 wells, using the MTT method [ 50 , 51 , 52 ] on the Caco-2-ATCC-HTB-37tumor cell line. Readings were performed at 24 and 48 h, using a Biobase BK-EL10C plate reader (Solantis, Bucharest Romania), at 492 nm [ 50 , 51 , 52 ].…”

Section: Methodsmentioning

confidence: 99%

“…Proliferation studies were performed in microplates with 96 wells, using the MTT method [ 50 , 51 , 52 ] on the Caco-2-ATCC-HTB-37tumor cell line. Readings were performed at 24 and 48 h, using a Biobase BK-EL10C plate reader (Solantis, Bucharest Romania), at 492 nm [ 50 , 51 , 52 ]. The proliferation index (PI) was calculated according to relation 2.…”

Section: Methodsmentioning

confidence: 99%

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Potential Antitumor Effect of Functional Yogurts Formulated with Prebiotics from Cereals and a Consortium of Probiotic Bacteria

Ciric

Radu

Zaharie

et al. 2023

Foods

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Various types of functional yogurts were obtained from normalized milk (with normalized lipid content) and a standardized probiotic consortium of probiotic bacteria named ABY3. All the types of yogurts obtained contained prebiotics from black or red rice; malt of barley, rye, wheat; or wheat bran. The physico-chemical analyses of all the functionalized products obtained showed that all of them met the quality standard for yogurt products. However, the sensorial analyses showed that the products obtained from black and red rice were of very good quality. The biological analyses indicated that all the types of products contained live probiotic bacteria, but wheat bran and red rice could increase their numbers. Tests performed on tumor cell line Caco-2 with corresponding postbiotics revealed cytotoxicity greater than 30% after 48 h of exposure in the case of yogurts obtained from milk with 0.8% lipid content and red rice or blond malt of barley. In the case of yogurts derived from milk with 2.5% lipid content, only the variants that contained blond malt of rye or wheat became cytotoxic against the Caco-2 cell line.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Potential Antitumor Effect of Functional Yogurts Formulated with Prebiotics from Cereals and a Consortium of Probiotic Bacteria

Ciric

Radu

Zaharie

et al. 2023

Foods

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show abstract

“…In the past few decades, efforts to improve efficacy of cancer treatment have been largely without success, highlighting the need for finding new solutions such as complementary treatment approaches in order to improve the response to chemotherapy [ 9 ]. Many natural herbal compounds have attracted the attention of both researchers and clinicians for their use in preventing or improving the current treatment of various chronic diseases, including different types of cancer [ 10 , 11 , 12 , 13 ]. Natural compounds are able to interact with multiple cellular targets associated with tumor growth, drug resistance, and metastasis, simultaneously making them a potential source of synergistic cancer treatments.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Resveratrol or Curcumin on Head and Neck Cancer Cells Sensitivity to the Cytotoxic Effects of Cisplatin

et al. 2020

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Natural compounds can modulate all three major phases of carcinogenesis. The role of the natural compounds such as resveratrol (RSV) and curcumin (CRM) in modulation of anticancer potential of platinum-based drugs (CisPt) is still a topic of considerable debate. In order to enhance head and neck cancer (HNSCC) cells’ sensitivity to the cytotoxic effects of CisPt combined treatments with RSV or CRM were used. The study aim was to evaluate how the RSV or CRM associated to CisPt treatment modulated some cellular processes such as proliferation, P21 gene expression, apoptotic process, and cell cycle development in HNSCC tumor cell line (PE/CA-PJ49) compared to a normal cell line (HUVEC). The results showed that RSV or CRM treatment affected the viability of tumor cells more than normal cells. These natural compounds act against proliferation and sustain the effects of cisplatin by cell cycle arrest, induction of apoptosis and amplification of P21 expression in tumor cells. In conclusion, using RSV or CRM as adjuvants in CisPt therapy might have a beneficial effect by supporting the effects induced by CisPt.

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Liquid crystal biomimetic nanosystems loaded with vegetal extracts

Barbinta-Patrascu

2019

Molecular Crystals and Liquid Crystals

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Influence of some spice food based bioproducts on human monocytic cells line type THP-1

Cited by 8 publications

References 13 publications

Potential Antitumor Effect of Functional Yogurts Formulated with Prebiotics from Cereals and a Consortium of Probiotic Bacteria

Potential Antitumor Effect of Functional Yogurts Formulated with Prebiotics from Cereals and a Consortium of Probiotic Bacteria

The Effect of Resveratrol or Curcumin on Head and Neck Cancer Cells Sensitivity to the Cytotoxic Effects of Cisplatin

Liquid crystal biomimetic nanosystems loaded with vegetal extracts

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