Influence of structural, textural and surface properties of mesostructured silica and aluminosilicate carriers on aminoglycoside uptake and in vitro delivery

Berger, Daniela; Băjenaru, Laura; Năstase, Silviu; Mitran, Raul−Augustin; Munteanu, Cornel; Matei, Cristian

doi:10.1016/j.micromeso.2014.12.022

Cited by 23 publications

(9 citation statements)

References 53 publications

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“…At the same time, very few reports are available on MCM-48, another important member of the M41S family as drug delivery carrier [40][41][42][43]. Arruebo [39].…”

Section: Introductionmentioning

confidence: 99%

Functionalized MCM-48 as Carrier for In Vitro Controlled Release of an Active Biomolecule, L-Arginine

Patel¹,

Solanki²

2020

Advances in Microporous and Mesoporous Materials

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The present chapter describes the synthesis, characterizations, and application of MCM-48 functionalized by an inorganic moiety, as a carrier. MCM-48 functionalized by 12-tungstophophoric acid (TPA) (TPA-MCM-48) and L-arginine was loaded into pure as well as functionalized MCM-48. Both the materials were characterized by various physicochemical techniques and evaluated for in vitro release of L-arginine at body temperature under different conditions. A study on release kinetics was carried out using first-order release kinetic model, while the mechanism were by Higuchi model. Further, to see the influence of TPA on release rate, release profile obtained from pure and functionalized MCM-48 was compared.

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“…At the same time, very few reports are available on MCM-48, another important member of the M41S family as drug delivery carrier [40][41][42][43]. Arruebo [39].…”

Section: Introductionmentioning

confidence: 99%

Functionalized MCM-48 as Carrier for In Vitro Controlled Release of an Active Biomolecule, L-Arginine

Patel¹,

Solanki²

2020

Advances in Microporous and Mesoporous Materials

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“…The beads are insoluble in acidic environment, preventing the release of loaded therapeutic agent in gastric fluid (pH 1.2) and allowing the drug to reach the intestinal tract [21]. At higher pH, in intestinal fluid (pH 7.4), the alginate beads swell and allow the delivery of loaded biologically active guest molecules in the intestine [22,23].…”

mentioning

confidence: 99%

Silica-Alginate Beads for Intestinal Ketoprofen Delivery

Petrescu¹,

Mitran²,

Matei³

et al. 2019

Rev. Chim.

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Herein, studies on ketoprofen delivery systems based on silica-alginate beads developed for the drug intestinal release for reducing its side effects were reported. The influence of surface properties, pore size and geometry of mesoporous silica carriers on the ketoprofen release kinetics was studied by using pristine and 3-aminopropyl functionalized MCM 41 (Mobile Composition of Matter) and MCF (mesocellular foam silica) materials. The ketoprofen loaded mesoporous silica coated with alginate is a pH-triggered system able to slow down the drug release rate in the targeted environment.

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“…A reduction in the pore diameter aer loading was noticed for NPA-0@CUR, NPA-24@CUR and NPA-100@CUR, whereas a pore size enlargement was determined for NPA-30@CUR and NPA-56@CUR samples that could be assigned to the total lling of smaller pores and the remaining several free larger pores. 59 Moreover, the increase in pore size can be attributed to an inhomogeneous distribution of CUR molecules in pores (Table 1) 60 and blocking of smaller pore size during the loading process. 12 The pore size distribution of the latter carriers clearly shows this phenomenon (Fig.…”

mentioning

confidence: 99%

Synthesis of nanostructured alumina with ultrahigh pore volume for pH-dependent release of curcumin

2017

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In a new approach, a series of nanoporous non-crystalline alumina (NPA) materials was designed and developed by an evaporation-induced self-assembly method in the presence of various weight ) and large pore sizes (up to 23.0 nm). The results indicated that higher pore volume (2.00 cm 3 g À1 ) was obtained when only tetrabutylammonium bromide (namely NPA-100) was used than when only P123 namely NPA-0 (0.5 cm 3 g À1) was used as a template. These new supports were used, for the first time, as an inorganic host for poorly soluble guest of curcumin (CUR). XRD analysis confirmed the amorphous state of CUR after being loaded into the NPAs, which is indicative of the full dispersion of the drug into the pores. The in vitro release behavior of these compounds was studied in simulated gastric fluid (SGF, pH ¼ 1.2) and simulated intestinal fluid (SIF, pH ¼ 6.8). The result indicated that the release of insoluble curcumin reached 80% in SGF when it was supported on alumina with ultrahigh pore volume. Moreover, this carrier showed high drug adsorption. The potential of the NPA-100@CUR in protecting SH-SY5Y cells from oxidative stress by toxin 6-OHDA that caused parkinsonian was tested. The results indicated that the formulation neutralizes 6-OHDA toxicity and significantly enhances cell survival.

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Influence of structural, textural and surface properties of mesostructured silica and aluminosilicate carriers on aminoglycoside uptake and in vitro delivery

Cited by 23 publications

References 53 publications

Functionalized MCM-48 as Carrier for In Vitro Controlled Release of an Active Biomolecule, L-Arginine

Functionalized MCM-48 as Carrier for In Vitro Controlled Release of an Active Biomolecule, L-Arginine

Silica-Alginate Beads for Intestinal Ketoprofen Delivery

Synthesis of nanostructured alumina with ultrahigh pore volume for pH-dependent release of curcumin

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