Influence of substrate temperature parameter on electrospinning process: example of application to the formation of gelatin fibers

Morsy, Reda

doi:10.1007/s00289-022-04109-1

Cited by 3 publications

(2 citation statements)

References 37 publications

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“…(A) Optical microscope images (magnification: 100×) of the number of gelatin fibers electrospun on a glass slide for a 5 s and b 25 s …”

Section: Gelatin and Gelatin-based Fibersmentioning

confidence: 99%

Design of Collagen and Gelatin-based Electrospun Fibers for Biomedical Purposes: An Overview

Larue,

Michely,

Grande

et al. 2024

ACS Biomater. Sci. Eng.

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Collagen and gelatin are essential natural biopolymers commonly utilized in biomaterials and tissue engineering because of their excellent physicochemical and biocompatibility properties. They can be used either in combination with other biomacromolecules or particles or even exclusively for the enhancement of bone regeneration or for the development of biomimetic scaffolds. Collagen or gelatin derivatives can be transformed into nanofibrous materials with porous micro-or nanostructures and superior mechanical properties and biocompatibility using electrospinning technology. Specific attention was recently paid to electrospun mats of such biopolymers, due to their high ratio of surface area to volume, as well as their biocompatibility, biodegradability, and low immunogenicity. The fiber mats with submicro-and nanometer scale can replicate the extracellular matrix structure of human tissues and organs, making them highly suitable for use in tissue engineering due to their exceptional bioaffinity. The drawbacks may include rapid degradation and complete dissolution in aqueous media. The use of gelatin/ collagen electrospun nanofibers in this form is thus greatly restricted for biomedicine. Therefore, the cross-linking of these fibers is necessary for controlling their aqueous solubility. This led to enhanced biological characteristics of the fibers, rendering them excellent options for various biomedical uses. The objective of this review is to highlight the key research related to the electrospinning of collagen and gelatin, as well as their applications in the biomedical field. The review features a detailed examination of the electrospinning fiber mats, showcasing their varying structures and performances resulting from diverse solvents, electrospinning processes, and cross-linking methods. Judiciously selected examples from literature will be presented to demonstrate major advantages of such biofibers. The current developments and difficulties in this area of research are also being addressed.

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“…(A) Optical microscope images (magnification: 100×) of the number of gelatin fibers electrospun on a glass slide for a 5 s and b 25 s …”

Section: Gelatin and Gelatin-based Fibersmentioning

confidence: 99%

Design of Collagen and Gelatin-based Electrospun Fibers for Biomedical Purposes: An Overview

Larue,

Michely,

Grande

et al. 2024

ACS Biomater. Sci. Eng.

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“…Traditional methods to enhance this differential involve either heating or cooling strategies. In the realm of electrospinning, active solution heating emerges as a superior method. , This approach not only creates a larger temperature difference but also beneficially impacts the polymer solution by enhancing solubility and reducing viscosity . Typically, solution heating in electrospinning is achieved using a syringe jacket heater .…”

Section: Introductionmentioning

confidence: 99%

Heat’s Role in Solution Electrospinning: A Novel Approach to Nanofiber Structure Optimization

Wildy,

Wei,

et al. 2024

Langmuir

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In this study, we explored an innovative application of heat-assisted solution electrospinning, a technique that significantly advances the control of phase separation in polystyrene (PS) fibers. Our experimental approach involved the use of direct heating and a convection air sheath applied through a coaxial needle, focusing on solvents with varying vapor pressures. This method enabled a detailed investigation into how solvent evaporation rates affect the morphology of the electrospun fibers. SEM and AFM measurements revealed that the application of direct heating and a heated air sheath offered precise control over the fiber morphology, significantly influencing both the surface and internal structure of the fibers. Additionally, we observed notable changes in fiber diameter, indicating that heat-assisted electrospinning can be effectively utilized to tailor fiber dimensions according to specific application requirements. Moreover, our research demonstrated the critical role of solvent properties, particularly vapor pressure, in determining the final characteristics of the electrospun fibers. By comparing fibers produced with different solvents, we gained insights into the complex interplay between solvent dynamics and heat application in fiber formation. The implications of these findings are far-reaching, offering new possibilities for the fabrication of nanofibers with customized properties. Furthermore, this could have profound impacts on various applications, from biomedical to environmental, where specific fiber characteristics are crucial. This study not only contributes to the understanding of phase separation in electrospinning but also opens avenues for further research on the optimization of fiber properties for diverse industrial and scientific applications.

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Aloe vera mucilage loaded gelatin electrospun fibers contained in polylactic acid coaxial system and polylactic acid and poly(e-caprolactone) tri-layer membranes for tissue engineering

Castillo Ortega,

Quiroz Castillo,

Del Castillo Castro

et al. 2024

BME

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BACKGROUND: Polymeric electrospun mats have been used as scaffolds in tissue engineering for the development of novel materials due to its characteristics. The usage of synthetic materials has gone in decline due to environmental problems associated with their synthesis and waste disposal. Biomaterials such as biopolymers have been used recently due to good compatibility on biological applications and sustainability. OBJECTIVE: The purpose of this work is to obtain novel materials based on synthetic and natural polymers for applications on tissue engineering. METHODS: Aloe vera mucilage was obtained, chemically characterized, and used as an active compound contained in electrospun mats. Polymeric scaffolds were obtained in single, coaxial and tri-layer structures, characterized and evaluated in cell culture. RESULTS: Mucilage loaded electrospun fibers showed good compatibility due to formation of hydrogen bonds between polymers and biomolecules from its structure, evidenced by FTIR spectra and thermal properties. Cell viability test showed that most of the obtained mats result on viability higher than 75%, resulting in nontoxic materials, ready to be used on scaffolding applications. CONCLUSION: Mucilage containing fibers resulted on materials with potential use on scaffolding applications due to their mechanical performance and cell viability results.

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Influence of substrate temperature parameter on electrospinning process: example of application to the formation of gelatin fibers

Cited by 3 publications

References 37 publications

Design of Collagen and Gelatin-based Electrospun Fibers for Biomedical Purposes: An Overview

Design of Collagen and Gelatin-based Electrospun Fibers for Biomedical Purposes: An Overview

Heat’s Role in Solution Electrospinning: A Novel Approach to Nanofiber Structure Optimization

Aloe vera mucilage loaded gelatin electrospun fibers contained in polylactic acid coaxial system and polylactic acid and poly(e-caprolactone) tri-layer membranes for tissue engineering

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