Influence of surface functionalization and particle size on the aggregation kinetics of engineered nanoparticles

Liu, Junfeng; Legros, Samuel; Ma, Guibin; Veinot, Jonathan G. C.; Kammer, Frank von der; Hofmann, Thilo

doi:10.1016/j.chemosphere.2012.01.045

Cited by 102 publications

(70 citation statements)

References 37 publications

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“…48 The EPM values showed gradual decrease with the increase in NaCl and CaCl 2 concentrations, with a ∼1.5 log concentration separation. In presence of NaCl 50 The relatively higher EPM values in such cases likely have resulted from a higher coverage of relatively smaller molecular weight surface coatings compared to that of poly(acrylic acid).…”

Section: ■ Results and Discussionmentioning

confidence: 95%

Mechanistic Heteroaggregation of Gold Nanoparticles in a Wide Range of Solution Chemistry

Afrooz

Khan

Hussain

et al. 2013

Environ. Sci. Technol.

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Heteroaggregation behavior of gold nanospheres (AuNS) in presence of pluronic acid (PA) modified single-walled carbon nanotubes (PA-SWNTs) was systematically studied for a wide range of mono- and divalent (NaCl and CaCl(2)) electrolyte conditions. Homoaggregation rates of AuNS were also determined to delineate heteroaggregation mechanisms. Time resolved dynamic light scattering (DLS) was employed to monitor aggregation. The homoaggregation of AuNS showed classical Derjaguin-Landau-Verwey-Overbeek (DLVO) type behavior with defined reaction limited (RLCA) and diffusion limited (DLCA) aggregation regimes. PA-SWNTs homoaggregation on the one hand showed no response with electrolyte increase. AuNS heteroaggregation rates on the other hand, showed regime dependent response. At low electrolyte or RLCA regime, AuNS heteroaggregation showed significantly slower rates, compared to its homoaggregation behavior; whereas enhanced heteroaggregation was observed for DLCA regime. The key mechanisms of heteroaggregation of AuNS are identified as obstruction to collision at RLCA regime and facilitating enhanced attachment at DLCA regime manifested by the presence of PA-SWNTs. Presence of Suwannee River humic acid (SRHA) showed aggregation enhancement for both homo- and hetero-systems, in presence of divalent Ca(2+) ions. Bridging between SRHA molecules is identified as the key mechanism for increased aggregation rate. The findings of this study are relevant particularly to coexistence of engineered nanomaterials. The strategy of using nonaggregating PA-SWNTs is a novel experimental strategy that can be adopted elsewhere to further the heteroaggregation studies for a wider set of particles and surface coatings.

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Section: ■ Results and Discussionmentioning

confidence: 95%

Mechanistic Heteroaggregation of Gold Nanoparticles in a Wide Range of Solution Chemistry

Afrooz

Khan

Hussain

et al. 2013

Environ. Sci. Technol.

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“…A number of studies have illustrated the effects of CNT length on inflammation and granuloma formation (Poland et al, 2008), cytotoxicity (Liu et al, 2012), oxidative stress (Kagan et al, 2010) and epithelial barrier function (Rotoli et al, 2009). Furthermore, the length can influence the retention and clearance of CNTs from the lung, thereby contributing to the asbestos-like responses in the pleural cavity of the lung leading to acute inflammation and progressive fibrosis (Murphy et al, 2011).…”

Section: Physicochemical Properties Of Cnts Affecting Toxicitiesmentioning

confidence: 99%

Pulmonary toxicity and fibrogenic response of carbon nanotubes

Manke

Wang

Rojanasakul

2013

Toxicology Mechanisms and Methods

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Carbon nanotubes (CNTs) have been a subject of intensive research for a wide range of applications. However, because of their extremely small size and light weight, CNTs are readily inhaled into human lungs resulting in increased rates of pulmonary disorders, most notably fibrosis. Several studies have demonstrated the fibrogenic effects of CNTs given their ability to translocate into the surrounding areas in the lung causing granulomatous lesions and interstitial and sub-pleural fibrosis. However, the mechanisms underlying the disease process remain obscure due to the lack of understanding of the cellular interactions and molecular targets involved. Interestingly, certain physicochemical properties of CNTs have been shown to affect their respiratory toxicity, thereby becoming significant determinants of fibrogenesis. CNT-induced fibrosis involves a multitude of cell types and is characterized by the early onset of inflammation, oxidative stress and accumulation of extracellular matrix. Increased reactive oxygen species activate various cytokine/growth factor signaling cascades resulting in increased expression of inflammatory and fibrotic genes. Profibrotic growth factors and cytokines contribute directly to fibroblast proliferation and collagen production. Given the role of multiple players during the pathogenesis of CNT-induced fibrosis, the objective of this review is to summarize the key findings and discuss major cellular and molecular events governing pulmonary fibrosis. We also discuss the physicochemical properties of CNTs and their effects on pulmonary toxicities as well as various biological factors contributing to the development of fibrosis.

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“…In general, a number of studies have illustrated the CNT length-dependent adverse effects on pleural inflammation and granuloma formation [11,12], cytotoxicity [13], and inflammasome activation [14]. Additionally, fiber length has been shown to dictate multi-walled CNT (MWCNT) retention and clearance from the lungs [12,15].…”

Section: Introductionmentioning

confidence: 99%

Effect of Fiber Length on Carbon Nanotube-Induced Fibrogenesis

Manke

Luanpitpong

Dong

et al. 2014

IJMS

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Given their extremely small size and light weight, carbon nanotubes (CNTs) can be readily inhaled by human lungs resulting in increased rates of pulmonary disorders, particularly fibrosis. Although the fibrogenic potential of CNTs is well established, there is a lack of consensus regarding the contribution of physicochemical attributes of CNTs on the underlying fibrotic outcome. We designed an experimentally validated in vitro fibroblast culture model aimed at investigating the effect of fiber length on single-walled CNT (SWCNT)-induced pulmonary fibrosis. The fibrogenic response to short and long SWCNTs was assessed via oxidative stress generation, collagen expression and transforming growth factor-beta (TGF-β) production as potential fibrosis biomarkers. Long SWCNTs were significantly more potent than short SWCNTs in terms of reactive oxygen species (ROS) response, collagen production and TGF-β release. Furthermore, our finding on the length-dependent in vitro fibrogenic response was validated by the in vivo lung fibrosis outcome, thus supporting the predictive value of the in vitro model. Our results also demonstrated the key role of ROS in SWCNT-induced collagen expression and TGF-β activation, indicating the potential mechanisms of length-dependent SWCNT-induced fibrosis. Together, our study provides new evidence for the role of fiber length in SWCNT-induced lung fibrosis and offers a rapid cell-based assay for fibrogenicity testing of nanomaterials with the ability to predict pulmonary fibrogenic response in vivo.

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Influence of surface functionalization and particle size on the aggregation kinetics of engineered nanoparticles

Cited by 102 publications

References 37 publications

Mechanistic Heteroaggregation of Gold Nanoparticles in a Wide Range of Solution Chemistry

Mechanistic Heteroaggregation of Gold Nanoparticles in a Wide Range of Solution Chemistry

Pulmonary toxicity and fibrogenic response of carbon nanotubes

Effect of Fiber Length on Carbon Nanotube-Induced Fibrogenesis

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