Influence of treadmill training on motor performance and organization of exploratory behavior in Meriones unguiculatus with unilateral ischemic stroke: Histological correlates in hippocampal CA1 region and the neostriatum

Araújo, Fernanda Lopes Buiatti de; Bertolino, Guilherme; Funayama, Carolina Araújo Rodrigues; Coimbra, Norberto Cysne; Araújo, João Luiz Vitorino

doi:10.1016/j.neulet.2007.11.038

Cited by 18 publications

(11 citation statements)

References 26 publications

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“…The histological data obtained in this work show that the neurons in the CA1 area of the hippocampus had their peak of neuronal death 4 days post-ischemia, corroborating a previous study from this laboratory [6], and the behavioral data obtained in the Rota rod test suggest that learning appears to be essential for good performance in this test [19][20][21].…”

Section: Discussionsupporting

confidence: 89%

“…UNI4OCL and UNI6OCL-left common carotid artery was exposed and occluded, and the suture thread was tied, leading to definitive occlusion of the artery as described elsewhere [6].…”

Section: Proceedurementioning

confidence: 99%

“…The Rota rod is widely used to assess motor behavior in experiments with focal or global brain injuries in rats and mice [3,9]. The test was performed the same way as in a previous study from our laboratory [6].…”

Section: Rota Rod Testmentioning

confidence: 99%

“…The main characteristic of this model is the significant delay between the time of the lesion and cellular death, which generally occurs anywhere from 12 h to several days. This delay depends on the cell population and lesion duration [6,7]. In this sense, the behavioral and morphologic responses depend on the time when the evaluation begins, probably because the affected structures react differently to ischemia and repair mechanisms [8].…”

Section: Introductionmentioning

confidence: 99%

“…In fact, it was demonstrated that unilateral carotid occlusion causes significant damage in neostriatum and motor cortex six days after the occlusion followed by reperfusion [6].…”

Section: Introductionmentioning

confidence: 99%

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Neuropathology and behavioral impairments after three types of global ischemia surgery in Meriones unguiculatus: Evidence in motor cortex, hippocampal CA1 region and the neostriatum

Araújo

Bertolino

Gonçalves

et al. 2012

Journal of the Neurological Sciences

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Section: Discussionsupporting

confidence: 89%

“…UNI4OCL and UNI6OCL-left common carotid artery was exposed and occluded, and the suture thread was tied, leading to definitive occlusion of the artery as described elsewhere [6].…”

Section: Proceedurementioning

confidence: 99%

Section: Rota Rod Testmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…In fact, it was demonstrated that unilateral carotid occlusion causes significant damage in neostriatum and motor cortex six days after the occlusion followed by reperfusion [6].…”

Section: Introductionmentioning

confidence: 99%

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Neuropathology and behavioral impairments after three types of global ischemia surgery in Meriones unguiculatus: Evidence in motor cortex, hippocampal CA1 region and the neostriatum

Araújo

Bertolino

Gonçalves

et al. 2012

Journal of the Neurological Sciences

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Comparison of Glial Activation in the Hippocampal CA1 Region Between The Young and Adult Gerbils After Transient Cerebral Ischemia

et al. 2012

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It has been reported that young animals are less vulnerable to brain ischemia. In the present study, we compared gliosis in the hippocampal CA1 region of the young gerbil with those in the adult gerbil induced by 5 min of transient cerebral ischemia by immunohistochemistry and western blot for glial cells. We used male gerbils of postnatal month 1 (PM 1) as the young and PM 6 as the adult. Neuronal death in CA1 pyramidal neurons in the adult gerbil occurred at 4 days post-ischemia; the neuronal death in the young gerbil occurred at 7 days post-ischemia. The findings of glial changes in the young gerbil after ischemic damage were distinctively different from those in the adult gerbil. Glial fibrillary acidic protein-immunoreactive astrocytes, ionized calcium-binding adapter molecule (Iba-1), and isolectin B4-immunoreactive microglia in the ischemic CA1 region were activated much later in the young gerbil than in the adult gerbil. In brief, very less gliosis occurred in the hippocampal CA1 region of the young gerbil than in the adult gerbil after transient cerebral ischemia.

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Neuroprotection of Ischemic Preconditioning is Mediated by Anti-inflammatory, Not Pro-inflammatory, Cytokines in the Gerbil Hippocampus Induced by a Subsequent Lethal Transient Cerebral Ischemia

et al. 2015

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Ischemic preconditioning (IPC) induced by sublethal transient cerebral ischemia could reduce neuronal damage/death following a subsequent lethal transient cerebral ischemia. We, in this study, compared expressions of interleukin (IL)-2 and tumor necrosis factor (TNF)-α as pro-inflammatory cytokines, and IL-4 and IL-13 as anti-inflammatory cytokines in the gerbil hippocampal CA1 region between animals with lethal ischemia and ones with IPC followed by lethal ischemia. In the animals with lethal ischemia, pyramidal neurons in the stratum pyramidale (SP) of the hippocampal CA1 region were dead at 5 days post-ischemia; however, IPC protected the CA1 pyramidal neurons from lethal ischemic injury. Expressions of all cytokines were significantly decreased in the SP after lethal ischemia and hardly detected in the SP at 5 days post-ischemia because the CA1 pyramidal neurons were dead. IPC increased expressions of anti-inflammatory cytokines (IL-4 and IL-13) in the stratum pyramidale of the CA1 region following no lethal ischemia (sham-operation), and the increased expressions of IL-4 and IL-13 by IPC were continuously maintained is the SP of the CA1 region after lethal ischemia. However, pro-inflammatory cytokines (IL-2 and TNF-α) in the SP of the CA1 region were similar those in the sham-operated animals with IPC, and the IL-4 and IL-13 expressions in the SP were maintained after lethal ischemia. In conclusion, this study shows that anti-inflammatory cytokines significantly increased and longer maintained by IPC and this might be closely associated with neuroprotection after lethal transient cerebral ischemia.

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Influence of treadmill training on motor performance and organization of exploratory behavior in Meriones unguiculatus with unilateral ischemic stroke: Histological correlates in hippocampal CA1 region and the neostriatum

Cited by 18 publications

References 26 publications

Neuropathology and behavioral impairments after three types of global ischemia surgery in Meriones unguiculatus: Evidence in motor cortex, hippocampal CA1 region and the neostriatum

Neuropathology and behavioral impairments after three types of global ischemia surgery in Meriones unguiculatus: Evidence in motor cortex, hippocampal CA1 region and the neostriatum

Comparison of Glial Activation in the Hippocampal CA1 Region Between The Young and Adult Gerbils After Transient Cerebral Ischemia

Neuroprotection of Ischemic Preconditioning is Mediated by Anti-inflammatory, Not Pro-inflammatory, Cytokines in the Gerbil Hippocampus Induced by a Subsequent Lethal Transient Cerebral Ischemia

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