Influence of treatment on the outcome of dogs with incompletely excised grade-2 mast cell tumors

Abstract

In this study we compared the outcomes of dogs with incompletely-excised grade-2 mast cell tumors (incompletely- excised grade-2 MCTs) either adjuvantly treated or not. Dogs with a grade-2 mast cell tumour (MCT) excised either incompletely or with narrow (.

Long-term postsurgical outcomes of mast cell tumors resected with a margin proportional to the tumor diameter in 23 dogs

“…It has recently been proposed that all tumors with HTFM > 0 mm be classified as complete [8]. Using this criterion, the rate of incomplete resection (HTFM = 0 mm ) with PM resection was 15% (7/47) in a cohort of grade Two dogs with MCTs judged as incomplete in the present study showed no local recurrence, as often observed in previous studies [4,15,[16][17][18][19]. In these two cases, there were scattered mast cells at the surgical margin of the muscle far away from the tumor foci; these cells may have been non-neoplastic mast cells [4,15].…”

Histologic margins and the residual tumour classification scheme: Is it time to use a validated scheme in human oncology to standardise margin assessment in veterinary oncology?

“…This term is rarely used in human oncology and the use of this term is not recommended according to a consensus paper by the American College of Veterinary Pathologists Oncology Committee on the evaluation and reporting of histologic margins in veterinary oncology . Furthermore, there is no consensus on what constitutes a close margin and this has not been clinically validated; 1 mm, 2 mm, 3 mm, 5 mm and 10 mm have been variably used in published veterinary studies, and 4 mm was preferred according to an online poll of veterinary pathologists . In some studies, close histologic excisions have been combined with incomplete histologic excisions, but there is no supporting literature to consider these two groups as equivalent because their outcomes have not been assessed separately .…”

“…While further local treatment significantly improved survival time in these dogs, this effect was lost when dogs with close histologic excisions were excluded from analysis . In another study of 115 dogs with incompletely (78%) or closely (defined as HTFM <5 mm, 22%) excised cutaneous MCTs, 23 dogs were not treated and 92 dogs received further local treatment. No statistically significant differences were found in local recurrence rates, disease‐free intervals, metastatic rates, survival times and 1‐ and 2‐year survival rates between treated dogs and non‐treated dogs, or between dogs treated with different modalities .…”

“…In another study of 115 dogs with incompletely (78%) or closely (defined as HTFM <5 mm, 22%) excised cutaneous MCTs, 23 dogs were not treated and 92 dogs received further local treatment. No statistically significant differences were found in local recurrence rates, disease‐free intervals, metastatic rates, survival times and 1‐ and 2‐year survival rates between treated dogs and non‐treated dogs, or between dogs treated with different modalities . Treatment complications associated with further local treatment were reported in 22% of dogs treated with re‐excision and 90% of dogs treated with radiation therapy .…”

“…No statistically significant differences were found in local recurrence rates, disease-free intervals, metastatic rates, survival times and 1-and 2-year survival rates between treated dogs and non-treated dogs, or between dogs treated with different modalities. 37 Treatment complications associated with further local treatment were reported in 22% of dogs treated with re-excision and 90% of dogs treated with radiation therapy. 32 In another study of 27 dogs with incompletely or closely excised MCTs, where incomplete excision was defined as <2 mm and close excision was defined as 2 to 5 mm, treated with vinblastine and prednisone for local tumour control, 23 13% of doses were associated with adverse effects and one dog died as a result of treatment.…”