Influence of vascular endothelial growth factor on angiogenesis and neurogenesis

Rud'ko, A S; Efendieva, M Kh; Budzinskaya, M.V.; Karpilova, M A

doi:10.17116/oftalma2017133375-80

Cited by 14 publications

(4 citation statements)

References 60 publications

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“…We noted decreasing VEGFR-1 serum levels over time during acute and early subacute phases of ischemic and hemorrhagic strokes. The main functions of VEGFR-1 could be both the transmission of mitotic signals and downregulation of VEGF-A in vascular endothelial cells, supported by the existence of the soluble VEGR receptor (sVEGFR-1) [ 48 ]. This form is not a transmembrane protein; it lacks a tyrosine kinase domain and is unable to transmit the signal, which in turn leads to the suppression of angiogenesis.…”

Section: Discussionmentioning

confidence: 99%

“…This form is not a transmembrane protein; it lacks a tyrosine kinase domain and is unable to transmit the signal, which in turn leads to the suppression of angiogenesis. Assuming that VEGFR-1 is a “ligand trap” which binds excess VEGF-A in the blood of stroke patients, the reversed direction of changes in VEGFR-1 and VEGF-A levels can appear obvious [ 48 , 49 ]. A decrease in VEGFR-1 due to inhibition of protein synthesis also remains possible.…”

Section: Discussionmentioning

confidence: 99%

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Serum Levels of VEGF-A and Its Receptors in Patients in Different Phases of Hemorrhagic and Ischemic Strokes

Babkina

Yadgarov

Острова

et al. 2022

CIMB

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Vascular endothelial growth factors (VEGFs) are important regulators of angiogenesis, neuroprotection, and neurogenesis. Studies have indicated the association of VEGF dysregulation with the development of neurodegenerative and cerebrovascular diseases. We studied the changes in serum levels of VEGF-A, VEGFR-1, and VEGFR-2 in patients at various phases of ischemic and hemorrhagic strokes. Quantitative assessment of VEGF-A, VEGFR-1, and VEGFR-2 in serum of patients with hemorrhagic or ischemic stroke was performed by enzyme immunoassay in the hyper-acute (1–24 h from the onset), acute (up to 1–7 days), and early subacute (7 days to 3 months) phases of stroke, and then compared with the control group and each other. Results of our retrospective study demonstrated different levels of VEGF-A and its receptors at various phases of ischemic and hemorrhagic strokes. In ischemic stroke, increased VEGFR-2 level was found in the hyper-acute (p = 0.045) and acute phases (p = 0.024), while elevated VEGF-A and reduced VEGFR-1 levels were revealed in the early subacute phase (p = 0.048 and p = 0.012, respectively). In hemorrhagic stroke, no significant changes in levels of VEGF-A and its receptors were identified in the hyper-acute phase. In the acute and early subacute phases there was an increase in levels of VEGF-A (p < 0.001 and p = 0.006, respectively) and VEGFR-2 (p < 0.001 and p = 0.012, respectively). Serum levels of VEGF-A and its receptors in patients with hemorrhagic and ischemic stroke indicate different pathogenic pathways depending on the phase of the disease.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Serum Levels of VEGF-A and Its Receptors in Patients in Different Phases of Hemorrhagic and Ischemic Strokes

Babkina

Yadgarov

Острова

et al. 2022

CIMB

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“…It can bind to extracellular receptor tyrosine kinases and activate different intracellular signaling pathways, which will in turn stimulate vascular endothelial cell growth, survival, and proliferation ( Olsson et al, 2006 ). In mammals, the VEGF family consists of five subgroups: VEGF-A, VEGF-B, VEGF-C, VEGF-D, and the placenta growth factor ( Goel and Mercurio, 2013 ; Simons et al, 2016 ; Rud’ko et al, 2017 ). VEGF-A is the prototype member, with at least four isoforms: VEGF121, VEGF165, VEGF189, and VEGF206.…”

Section: Introductionmentioning

confidence: 99%

A Fluorescent Aptasensor Based on Assembled G-Quadruplex and Thioflavin T for the Detection of Biomarker VEGF165

Zheng

Gao

et al. 2021

Front. Bioeng. Biotechnol.

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VEGF165, a regulator of angiogenesis, has been widely used as a serum biomarker for a number of human diseases, including cancer, rheumatoid arthritis, bronchial asthma, and diabetic eye disease. The rapid, accurate, and convenient detection of VEGF165 is a crucial step in effective healthcare monitoring, disease diagnosis, and prognosis assessment. In this study, a fluorescent aptasensor based on an assembled G-quadruplex and the signal molecule ThT was developed for VEGF165 detection. First, G-rich DNA fragments were assembled at both ends of the anti-VEGF165 aptamer, and the B-DNA form was converted into a G-quadruplex structure aptamer (G4-Apt). Then, ThT was introduced, and the G-quadruplex significantly enhanced the fluorescence intensity of the bound ThT. When VEGF165 was present, the higher affinity of the aptamer to the target protein allowed the G4-Apt/VEGF165 complex to form and release ThT, which emitted only weak fluorescence in the free state. Therefore, the aptasensor exhibited a good linear detection window from 1.56 to 25 nM VEGF165, with a limit of detection of 0.138 nM. In addition, the aptasensor was applied to detect VEGF165 in clinical serum samples, showing good accuracy, reproducibility, and stability. These results indicate that our developed fluorescent aptasensor can potentially be a reliable, convenient, and cost-effective approach for the sensitive, specific, and rapid detection of the VEGF165 biomarker.

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“…Следовательно, VEGF и PlGF являются стимуляторами ангиогенеза и увеличивают проницаемость стенки сосудов внутри плацентарного русла, за счет аутокринного механизма регулируют дифференцировку, метаболическую активность и инвазию трофобласта при плацентации [15,18].…”

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The Role of Growth Factors in Trophoblast Invasion and Their Association With the Pathological Course of Pregnancy

Приходько

2019

Bûlletenʹ fiziologii i patologii dyhaniâ

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Контактная информация Николай Геннадьевич Приходько, аспирант, лаборатория механизмов этиопатогенеза и восстановительных процессов дыхательной системы при неспецифических заболеваниях легких, Федеральное государственное бюджетное научное учреждение «Дальневосточный научный центр физиологии и патологии дыхания, 675000, Россия, г. Благовещенск, ул. Калинина, 22.

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Influence of vascular endothelial growth factor on angiogenesis and neurogenesis

Cited by 14 publications

References 60 publications

Serum Levels of VEGF-A and Its Receptors in Patients in Different Phases of Hemorrhagic and Ischemic Strokes

Serum Levels of VEGF-A and Its Receptors in Patients in Different Phases of Hemorrhagic and Ischemic Strokes

A Fluorescent Aptasensor Based on Assembled G-Quadruplex and Thioflavin T for the Detection of Biomarker VEGF165

The Role of Growth Factors in Trophoblast Invasion and Their Association With the Pathological Course of Pregnancy

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