Influenza A — Group B Streptococcal Mixed Infection

Evlashev, Alexey; Meringova, L. F.; Леонтьева, Г. Ф.; Kramskaya, Tatiana; Dukhin, A I; Grabovskaya, K. B.; Тотолян, А А

doi:10.1007/978-1-4899-1825-3_223

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“…Previously, we studied the process of dual viral-bacterial infection, when the influenza virus was infected 3 days before or 3 days after the Group B streptococcus infection. In all cases, the aggravation of the disease and the transformation of a non-lethal form to a lethal infection were observed [34]. It is interesting to note that we registered the deterioration in survival also when mice were infected with influenza after stress, that is, the consequences of the non-infectious process similarly influenced the development of influenza superinfection.…”

Section: Discussionmentioning

confidence: 58%

Combined immunization with attenuated live influenza vaccine and chimeric pneumococcal recombinant protein improves the outcome of virus-bacterial infection in mice

et al. 2019

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Influenza and its bacterial complications are a leading cause of morbidity and mortality worldwide. The effect of combined immunization with live influenza vaccine and recombinant chimeric pneumococcal protein in dual infection caused by influenza H1N1 and S. pneumoniae (serotype 3) has been studied. The combined vaccine consisted of the strain A/California/2009/38 (H1N1) pdm and chimeric recombinant protein PSPF composed of immunodominant fragments of the surface virulence factors of S. pneumoniae—PsaA, PspA, and Shr1875—associated with modified salmonella flagellin. Vaccinated mice were infected with the influenza virus 24 hours before or 24 hours after the onset of pneumococcal infection. The protective effect of combined vaccination was shown on both models of viral-bacterial infection.

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Section: Discussionmentioning

confidence: 58%