Self-organization is a general mechanism for the creation of new structural pattern of systems. A pattern, in essence, is a relationship, an architecture, a way of organizing, and a structure of order, which can only be explained by information activities. The characteristics of self-organization behavior, such as openness, nonlinearity, inner randomness, inner feedback, information network, and holographic construction, provide corresponding conditions and basis for the self-organizing evolution of the system from the aspects of environmental information function, maintenance and construction of the overall information framework of the system, and exploration of new information mode of the system. Based on the general process and mechanism of self-organization system evolution, its corresponding basic stages have the significance and value of information activities. Generally speaking, the process of system elements differentiating from the original system is the decoupling of information association between relevant elements and original systems. The convergence process of forming system elements is the initial exploration of forming a new information model; the nucleation process of some initial stabilization modes is the creation of information codons; the development of the system according to a particular pattern is ergodic construction of information feedback chain indicated by information codon; the diffusion of system self-replication is the expansion of the quantity of the information model; the variation in system self-replication is the innovation process of introducing new information pattern; environment-based selection and evolution correspond to the complex development of information pattern; and the alternation of old and new structures in system evolution corresponds to the formation process of the whole information network framework of the new system. In order to explain the self-organization’s characteristics, processes, and mechanisms of system evolution at a more comprehensive level, the complexity research program must pay enough attention to and give due status to the information factors and information science creed. Moreover, the information science research creed may also provide some basic theoretical paradigms with core theoretical significance for complex system research.