Infrared fluorescence endoscopy for the diagnosis of superficial gastric tumors

Kimura, Tooru; Muguruma, Naoki; Ito, Susumu; Okamura, Seisuke; Imoto, Yoshitaka; Miyata, Hiroshi; Kaji, Masako; Kudo, Eiji

doi:10.1016/j.gie.2007.01.009

Cited by 55 publications

(38 citation statements)

References 18 publications

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“…In Japan, ICG is routinely administered to evaluate hepatic function prior to hepatic resection, as ICG is almost entirely excreted via the hepatobiliary system. Intravenously administered ICG has also been used in NIR endoscopy systems to successfully differentiate superficial gastric tumors from invasive cancers (13). ICG has been shown to localize to both hepatocellular carcinoma and intrahepatic metastases 24-72 hours after injection with high target-to-background ratios (2,3,6).…”

Section: Discussionmentioning

confidence: 99%

Interventional Optical Molecular Imaging Guidance during Percutaneous Biopsy

Sheth¹,

Heidari²,

Wood³

et al. 2014

Radiology

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Purpose:To investigate indocyanine green (ICG) as a molecular beacon for malignant lesions within the liver and evaluate the ability of a developed handheld imaging system to allow measurement of ICG fluorescence within focal hepatic lesions with high target-to-background ratios in a mouse model. Materials and Methods:All animal experiments were approved by the institutional animal care committee. A handheld optical molecular imaging device was constructed to pass through the introducer needle of a standard percutaneous biopsy kit. An ex vivo phantom system was constructed to quantify tissue attenuation properties of ICG in liver parenchyma. Subsequently, intrahepatic colorectal cancer metastases were generated in nude mice, and epifluorescence imaging of ICG, as well as histologic analysis of the explanted livers, was performed at 3 weeks after implantation (n = 6). Epifluorescence imaging with the handheld imaging device was then performed on intrahepatic colorectal metastases after the administration of ICG (n = 15) at 3, 6, and 24 hours after injection. Target-to-background ratios were calculated for each time point. Subsequently, a core biopsy of intrahepatic colorectal metastases was performed by using a standard clinical 18-gauge biopsy needle. Results:There was avid localization of ICG to the focal lesions at all time points. Similarly, fluorescence within the tumors was greater than that within normal liver, as detected with the handheld imaging system (mean target-to-background ratio 6 standard deviation, 3.9 6 0.2 at 24 hours). A core biopsy of tumor and normal adjacent liver by using a standard biopsy needle demonstrated a sharp margin of fluorescence intensity at the tumor-liver interface. Conclusion:The custom-designed molecular imaging device, in combination with ICG, readily allowed differentiation between normal and malignant tissue in a murine model of intrahepatic colorectal metastasis.q RSNA, 2014

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Section: Discussionmentioning

confidence: 99%

Interventional Optical Molecular Imaging Guidance during Percutaneous Biopsy

Sheth¹,

Heidari²,

Wood³

et al. 2014

Radiology

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“…It can be used to provide information of the vasculature of the digestive tract that cannot be obtained by conventional endoscopy [68]. Kimura et al [69] evaluated the effectiveness of fluorescent endoscopy for the preoperative evaluation of tumor invasion in patients with superficial gastric tumors, and concluded that submucosal invasion has a higher correlation with fluorescence than macroscopic morphology of tumors and histopathologic tumor differentiation. Indocyanine green has also been used for the detection of metastases to a sentinel lymph node in melanoma, gastric cancer, and lung cancer patients [70,71,72].…”

Section: Optical Imagingmentioning

confidence: 99%

Innovation in Cancer Imaging

Debergh

Vanhove²,

Ceelen³

2012

Eur Surg Res

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Cancer is rapidly becoming the worldwide leading cause of premature death. Iconographic techniques have traditionally provided information on tumor anatomy. The recent introduction of functional and molecular imaging techniques allows probing tumor physiology and biology in addition to mere anatomical description. In addition to the research implications, these novel imaging techniques offer early response assessment and target visualization which, in the era of personalized medicine, may offer significant advances in cancer therapy. Here, we provide an overview of the most important developments in cancer imaging, with a focus on the clinical applications.

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“…The ICCD camera was optically connected with the scope through an adapter into which the barrier filter was inserted. The new endoscopy system with a CCD at its tip has a greatly improved resolution: this system comprises of a light source apparatus, an infrared fluorescence endoscope, and image analysis software, which is the same as that used for a conventional system (Kimura et al, 2007). The light source apparatus (XCLV-260HP-IRF, Olympus) has three built-in filters; an infrared ray cut filter, an infrared ray pass filter, and a RGB filter.…”

Section: Infrared Fluorescence Endoscopementioning

confidence: 99%