Infrared Laser Light Further Improves Bone Healing When Associated with Bone Morphogenetic Proteins and Guided Bone Regeneration: An in Vivo Study in a Rodent Model

Abstract

We concluded that the use of laser photobiomodulation in association with BMPs, organic bovine bone grafts, and GBR increases the positive biomodulating effects of laser energy.

Stability of dental implants after irradiation with an 830-nm low-level laser: a double-blind randomized clinical study

“…The GaAlAs laser with an 830-nm wavelength was selected on the basis of successful results obtained on fibroblasts and also on osteoblasts, both in vitro and in vivo by different authors [15][16][17][33][34][35][36][37][38][39][40][41][42][43][44][45]. The infrared lasers are known to have a greater depth of tissue penetration in comparison to red or blue light [46], thus, the osteoblasts cells could better absorb the laser energy because of the low water absorption at that wavelength [33,36,45].…”

Repair of Surgical Bone Defects Grafted with Hydroxylapatite + β-TCP and Irradiated with λ=850 nm LED Light

“…These features were observed in many studies in which this group used similar parameters to the ones carried out with Laser Phototherapy (LPT) or LED-PT (2)(3)(4)(5)(6)(7)(8). It seems that the beneficial effects of LED-PT are similar to those of the laser.…”

“…This association may modulate the repair of bone defects in a manner similar to what is observed following the use of autologous bone graft, preventing its complications and limitations (2,4,5,8,11,12). However, the use of autologous grafts remains the gold standard for the treatment of bone defects (2,3).…”

“…Total energy delivered was 20 J/cm 2 per session and 140 J/cm 2 per treatment. Energy densities used were based upon previous studies carried out by the authors (1)(2)(3)(4)(5)(6)(7)(8)11,12). LED output power was confirmed by using a calibrated power meter (Thorlabs PM30-121; Thorlabs GmbH, Munich, Germany).…”

“…It is possible that the mechanism involved is similar to the light absorption by the cytochrome-C-oxidase present in the mitochondrial membrane (9,10). Despite the increase of successful reports of applications of different phototherapies in many areas, their use in bone repair associated with bone grafting with biomaterials needs to be further studied (4)(5)(6)(7)(8).…”