Infrared microspectroscopy studies on the protective effect of curcumin coated gold nanoparticles against H<sub>2</sub>O<sub>2</sub>-induced oxidative stress in human neuroblastoma SK-N-SH cells

Karimi, Fateme; Shaabani, Elnaz; Martínez-Rovira, I.; Yousef, Ibraheem; Ghahremani, Mohammad Hossein; Kharrazi, Sharmin

doi:10.1039/d1an01379c

Cited by 5 publications

(4 citation statements)

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“…[4][5][6] Molecular antioxidants can be found in plants and in the human body as well, but synthetic representatives are also known. 7,8 Immobilization in/on various nanoparticles is a common tool to enhance the sensitivity (against pH, light, pressure, temperature, ionic strength, etc.) of both enzymatic and non-enzymatic substances, which can facilitate biomedical and industrial applications.…”

Section: Introductionmentioning

confidence: 99%

Nanoclay-based sensor composites for the facile detection of molecular antioxidants

Szerlauth

Szalma

Muráth

et al. 2022

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Section: Introductionmentioning

confidence: 99%

Nanoclay-based sensor composites for the facile detection of molecular antioxidants

Szerlauth

Szalma

Muráth

et al. 2022

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“…The transmittance spectrum was obtained with melanin samples exposed to Cr(VI) and using non-exposed samples as control. The spectra of Cr(VI)-exposed melanin were acquired by subtracting the reference spectra from non-exposed raw melanin (4000-600 cm −1 ) according to the method of Karimi et al (2021). The subtraction was done directly (automatically) using the OPUS 7.5 software (Bruker, Germany).…”

Section: Physicochemical Characterization Of Melaninmentioning

confidence: 99%

Characterization of melanin from Exophiala mesophila with the prospect of potential biotechnological applications

Medina-Armijo,

Yousef,

Berná

et al. 2024

Front. Fungal Biol.

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IntroducionFungal melanin is an underexplored natural biomaterial of great biotechnological interest in different areas. This study investigated the physical, chemical, electrochemical, and metal-binding properties of melanin extracted from the metallotolerant black fungus Exophiala mesophila strain IRTA-M2-F10.Materials and methodsSpecific inhibitory studies with tricyclazole and biochemical profiling of whole cells by synchrotron radiation-based Fourier-transform infrared spectral microscopy (SR-FTIRM) were performed. An optimized extraction protocol was implemented, and purified fungal melanin was characterized using an array of spectrophotometric techniques (UV-Vis, FTIR, and EPR) and by cyclic voltammetry (CV) experiments. The metal-binding capacity of melanin extracts was also assessed by using Cr(VI) as a model heavy metal.ResultsInhibitory studies indicated that 1,8-dihydroxynaphthalene may be the main precursor molecule of E. mesophila melanin (DHN-melanin). The biochemical characterization of fungal melanin extracts were benchmarked against those from two melanins comprising the precursor molecule L-3,4-dihydroxiphenylalanine (DOPA-melanin): extracts from the ink of the cephalopod Sepia officinalis and DOPA-melanin synthesized in the laboratory. The CV results of melanin extracts incubated with and without cell suspensions of the electroconductive bacterium Geobacter sulfurreducens were indicative of novel semiquinone/hydroquinone redox transformations specific for each melanin type. These interactions may play an important role in cation exchange for the adsorption of metals and in microbial interspecies electron transfer processes.DiscussionThe obtained results provided further evidence for the DHN-nature of E. mesophila melanin. The FTIR profiling of melanin extracts exposed to Cr(VI), compared to unexposed melanin, resulted in useful information on the distinct surface-binding properties of fungal melanin. The parameters of the Langmuir and Freundlicht isotherms for the adsorption of Cr(VI) were determined and compared to bibliographic data. Altogether, the inherent properties of fungal melanin suggest its promising potential as a biomaterial for environmental applications.

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“…Binding a powerful scavenger such as curcumin has been shown to increase the efficacy of the scavenging and reduction of ROS throughout the body. One study found that this joint compound improved the efficiency of curcumin significantly due to the ability of Au to travel through the movement of water in the body (Karimi et al, 2021). This allows for Au to be potentially used as a radioprotective delivery agent, which has many different biomedical impacts with various compounds in the future.…”

Section: Noble Metal (Gold Silver and Platinum) Nps As Radioprotectantsmentioning

confidence: 99%

Nanotechnology enabled radioprotectants to reduce space radiation‐induced reactive oxidative species

Babu

Pawar

Mittal

et al. 2023

WIREs Nanomed Nanobiotechnol

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Interest in space exploration has seen substantial growth following recent launch and operation of modern space technologies. In particular, the possibility of travel beyond low earth orbit is seeing sustained support. However, future deep space travel requires addressing health concerns for crews under continuous, longer‐term exposure to adverse environmental conditions. Among these challenges, radiation‐induced health issues are a major concern. Their potential to induce chronic illness is further potentiated by the microgravity environment. While investigations into the physiological effects of space radiation are still under investigation, studies on model ionizing radiation conditions, in earth and micro‐gravity conditions, can provide needed insight into relevant processes. Substantial formation of high, sustained reactive oxygen species (ROS) evolution during radiation exposure is a clear threat to physiological health of space travelers, producing indirect damage to various cell structures and requiring therapeutic address. Radioprotection toward the skeletal system components is essential to astronaut health, due to the high radio‐absorption cross‐section of bone mineral and local hematopoiesis. Nanotechnology can potentially function as radioprotectant and radiomitigating agents toward ROS and direct radiation damage. Nanoparticle compositions such as gold, silver, platinum, carbon‐based materials, silica, transition metal dichalcogenides, and ceria have all shown potential as viable radioprotectants to mitigate space radiation effects with nanoceria further showing the ability to protect genetic material from oxidative damage in several studies. As research into space radiation‐induced health problems develops, this review intends to provide insights into the nanomaterial design to ameliorate pathological effects from ionizing radiation exposure.This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Nanotechnology Approaches to Biology > Cells at the Nanoscale Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease

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Infrared microspectroscopy studies on the protective effect of curcumin coated gold nanoparticles against H₂O₂-induced oxidative stress in human neuroblastoma SK-N-SH cells

Abstract: The contribution of oxidative stress in several chronic and degenerative diseases suggests that antioxidant therapy can be a promising therapeutic strategy. However, in the case of many antioxidants, their biodistribution...

Cited by 5 publications

References 57 publications

Nanoclay-based sensor composites for the facile detection of molecular antioxidants

Nanoclay-based sensor composites for the facile detection of molecular antioxidants

Characterization of melanin from Exophiala mesophila with the prospect of potential biotechnological applications

Nanotechnology enabled radioprotectants to reduce space radiation‐induced reactive oxidative species

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Infrared microspectroscopy studies on the protective effect of curcumin coated gold nanoparticles against H2O2-induced oxidative stress in human neuroblastoma SK-N-SH cells

Abstract: The contribution of oxidative stress in several chronic and degenerative diseases suggests that antioxidant therapy can be a promising therapeutic strategy. However, in the case of many antioxidants, their biodistribution...

Cited by 5 publications

References 57 publications

Nanoclay-based sensor composites for the facile detection of molecular antioxidants

Nanoclay-based sensor composites for the facile detection of molecular antioxidants

Characterization of melanin from Exophiala mesophila with the prospect of potential biotechnological applications

Nanotechnology enabled radioprotectants to reduce space radiation‐induced reactive oxidative species

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Product

Resources

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Infrared microspectroscopy studies on the protective effect of curcumin coated gold nanoparticles against H₂O₂-induced oxidative stress in human neuroblastoma SK-N-SH cells