The nighttime economy (NTE) is one of the primary measures used by the Chinese government to promote urban consumption and capital flow. Especially after COVID-19, more regulations were introduced by both the central and local governments to accelerate this commercial activity. However, the relationship between the NTE and urban development is controversial. There has been controversy over the relationship between the nighttime economy and urban development. We believe that organizations/individuals embedded in different regional contexts have different behavioral patterns, which, in turn, can make cities develop nighttime commercial activities differently. We wonder whether the nighttime economy’s large-scale development fits the diverse regional development. There is a lack of discussions of the spatial distribution of nighttime commercial activities from an urban geographical perspective, especially the differences and mechanisms of urban systems based on the nighttime economy. Based on existing research arguments, this article collects points of interest (POI) and nighttime light (NTL) remote sensing data (RSD) to spatialize nighttime economic activities in order to provide a reference for reasonable regional and urban economic planning. The nighttime economy (NTE) is one of the primary channels used by the Chinese government to promote urban consumption and capital flow, and the relationship between the NTE and urban development is controversial. Based on existing research, we selected the Yangtze River Delta (YRD) region as an example. We found that there are core–peripheral spatial patterns in nighttime commercial urban systems. The core is Shanghai, and provincial-level core cities form the second category, largely overlapping with the administrative urban system. Although the NTE is primarily concentrated in economically developed coastal areas, it spreads in the northwest–southeast direction, indicating that opportunities will arise in the geo-periphery. Although regulations encourage the growth of the NTE, infrastructure cannot fully support large-scale centralized expansion. The interaction of critical factors, such as urban policies, residents’ consumption, industrial structure, and economic foundations, may affect nighttime activities.