Infusão Contínua Versus Intermitente De Meropenem Na Prática Clínica

Simonato, Bruna Samways; Teixeira, Gabriella Cinthyane; Rebecca, Edirlene Sara Wisniewski; Ross, Claudia; Silva, Ligiane de Lourdes da

doi:10.25110/arqsaude.v21i1.2017.5389

Cited by 5 publications

(6 citation statements)

References 12 publications

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“…Na administração de medicamentos, infusões endovenosas podem ocorrer de forma contínua ou intermitente, rápida entre 3 e 5 minutos, em 30 minutos, ou em períodos de 1 a 3h, considerando fatores como condições do paciente e possíveis complicações (16) . A concentração da substância é importante fator a ser considerado.…”

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Knowledge about the use of potentially dangerous drugs among hospital health care nurses

et al. 2020

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Objective: to characterize the knowledge about the use of potentially dangerous drugs among hospital health care nurses. Methods: quantitative, descriptive-exploratory research, with the application of a validated questionnaire, translated and adapted in Brazil, on potentially dangerous medications, with 26 nursing assistants from a university hospital. Univariate and bivariate descriptive statistical analysis of the data was performed using the Statistical Package for Social Science, version 20. Scores ≥70% were considered as sufficient knowledge and insufficient knowledge scores <70%. Results: in the first domain of the questionnaire, called Medication Administration, the average percentage of correct answers was 64.6%. In the second domain, Clinical procedures, an average of 53.7% of correct answers was found. The use of electrolytes, chemotherapy and insulin were the main weaknesses in the knowledge of professionals. Conclusion: insufficient knowledge about the administration and clinical procedures of potentially dangerous drugs was identified among hospital care nurses in this scenario.

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Section: Discussionunclassified

Knowledge about the use of potentially dangerous drugs among hospital health care nurses

et al. 2020

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“…Therefore, it is important that a prescription contains, in addition to the dose, the infusion time so as not to influence the effectiveness of this medication 16 . Studies have shown that carbapenems, such as meropenem, in prolonged infusion for 3 hours demonstrate superiority in pK/pD and lower chances of adverse events 17 .…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial related problems in patients undergoing renal dialysis in a university hospital

Santos¹,

Domingues²

2020

Rev Bras Farm Hosp Serv Saude

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Objective: To detect antimicrobial drug-related problems (DRP) in adult patients undergoing renal dialysis in a university hospital. Methods: This is an observational and retrospective study in which were included patients hospitalized in antimicrobial therapy and submitted to renal replacement therapy (RRT) from January to August 2017. The study variables were collected on the first day that antimicrobial was administraded and hemodialysis was done. The Dáder Methodology was used to detect and classify the DRP and probable negative outcomes associated with medications (NOMs). Results: 85 patients were included, 62.4% (n=53) male, mean age 61.2 ± 15.2 years. An average of 2.6 ± 1.6 different antimicrobials prescribed per patient was observed, being the main class carbapenems (13.7%) and the main reason for antimicrobial use was sepsis (34.1%). The main DRPs found were: prescription error (45.1%), Y incompatibility (14.0%) and inadequate dosage (12.1%), median 6.0 (4-11) DRP per patient, minimum:1 and maximum:32. Regarding NOMs, the most frequent were quantitative insecurity (50.6%), non-quantitative insecurity (19.9%) and quantitative ineffectiveness (19.0%). Conclusions: All patients undergoing dialysis and antimicrobial therapy included in this study had at least one problem related to antimicrobial drugs and, therefore, one probable NOM. It was verified the need of a multiprofessional team working on the detection and prevention of avoidable problems, through the implantation of computerized systems, continuing education program, protocols and routines, allied with an institutional antimicrobial stewardship program.

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“…This antimicrobial provides coverage against several microorganisms, being useful and widely prescribed for the treatment of severe and nosocomial infections in hospitalized patients. [1][2][3] Meropenem, such as some other traditional antimicrobial agents, is a time-dependent drug and has a bactericidal action that inhibits bacterial cell wall synthesis. 3,4 For time-dependent drugs, the main parameter associated with therapeutic success is the percentage of time that the levels of antibiotics at the infection site exceed the minimum inhibitory concentration (%fT > MIC) of the pathogen.…”

Section: What Is K Nown and Objec Tivementioning

confidence: 99%

Meropenem use and therapeutic drug monitoring in clinical practice: a literature review

et al. 2021

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What is known and objective: Meropenem, a carbapenem antibiotic, is widely prescribed for the treatment of life-threatening infections. The main parameter associated with its therapeutic success is the percentage of time that the levels remain above the minimum inhibitory concentration. Inadequate levels of meropenem can lead to therapeutic failure and increase the possibility of microbial resistance. The employment of strategies involving dose regimens and drug pharmacodynamics has become increasingly important to optimize therapies. In the present study, we conducted a review with the purpose of assembling information about the clinical use of meropenem and therapeutic drug monitoring. Methods:A literature review emphasizing the application of therapeutic drug monitoring (TDM) of meropenem in clinical practice has been done. To identify articles related to the topic, we performed a standardized search from January 21, 2020 to December 21, 2020, using specific descriptors in PubMed, Lilacs and Embase.Results and discussion: In total, 35 studies were included in the review. The daily dose of meropenem commonly ranged from 3 to 6 g/day. Critically ill patients and those with impaired renal function appear to be the most suitable patients for the application of meropenem TDM, in order to guide therapy. We observed that most of the studies recommend TDM and that, in nine locations, the TDM of meropenem and of other beta-lactams is a routine practice. TDM data can help to maximize the clinical outcomes of the treatment with meropenem. It can also improve the patient care by providing suitable levels of meropenem, guiding the most appropriate dose regimens, which is the main parameter associated with therapeutic success. What is new and conclusion:The findings from this review suggest that the therapeutic monitoring of meropenem can be beneficial, since it adjusts the treatment and aids clinical outcomes. It does so by indicating the appropriate dosage and preventing failure, toxicity and possible antimicrobial resistance. The multidisciplinary effort, basic knowledge and communication among the medical team are also essential.

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Infusão Contínua Versus Intermitente De Meropenem Na Prática Clínica

Cited by 5 publications

References 12 publications

Knowledge about the use of potentially dangerous drugs among hospital health care nurses

Knowledge about the use of potentially dangerous drugs among hospital health care nurses

Antimicrobial related problems in patients undergoing renal dialysis in a university hospital

Meropenem use and therapeutic drug monitoring in clinical practice: a literature review

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