Inhalation challenge and pharmacologic studies of toluene diisocyanate (TDI)—sensitive workers

Hazardous air pollutants and asthma.

“…Another rosin-sensitive worker became reactive to pine trees and even unheated rosins or turpentine (144). In addition, bronchoprovocation tests have been positive in previously sensitized workers after exposure to concentrations as low as the current limit of chemical detection (i.e., 7 pg/m 3 toluene diisocyanate) (145)(146)(147)(148). Thus, once hypersensitivity has been initiated, the dose necessary to elicit subsequent response can be extremely low.…”

Respiratory symptoms and pulmonary function of workers exposed to cork dust, toluene diisocyanate and conidia.

“…Despite the known risk of asthma with exposure to TDI (5)(6)(7)(8)(9)(10)(11), its etiologic role in suberosis has not been considered until now. Furthermore, occupational exposure to cork dust in grinding and polishing has not been studied as a possible risk factor for other respiratory diseases.…”

Seroimmunological Characteristics of Korean Workers Exposed to Toluene Diisocyanate

“…In summary, the immunologic reaction in which IgE or IgG is involved is not the only developing mechanism of TDI asthma of Korean workers, and other nonimmunologic processes (Davies et al, 1977; Butcher et al, 1979) should be considered simultaneously.…”