Inhaled Nitric Oxide—Current Practice and Future Potential Uses and Development

Ichinose, Fumito; Zapol, Warren M.

doi:10.1016/b978-0-12-804273-1.00025-9

Cited by 3 publications

(2 citation statements)

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“…In addition, advances in the development and testing of an inexpensive, lightweight portable NO generating device from air will be described. The use of inhaled NO in other clinical areas including paediatric and adult pulmonary hypertension and chronic obstructive pulmonary disease have been reviewed elsewhere (Ichinose and Zapol, 2017a).…”

Section: Introductionmentioning

confidence: 99%

Inhaled nitric oxide

Ichinose

Bloch

et al. 2018

British J Pharmacology

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Nitric oxide (NO) is a gas that induces relaxation of smooth muscle cells in the vasculature. Because NO reacts with oxyhaemoglobin with high affinity, the gas is rapidly scavenged by oxyhaemoglobin in red blood cells and the vasodilating effects of inhaled NO are limited to ventilated regions in the lung. NO therefore has the unique ability to induce pulmonary vasodilatation specifically in the portions of the lung with adequate ventilation, thereby improving oxygenation of blood and decreasing intrapulmonary right to left shunting. Inhaled NO is used to treat a spectrum of cardiopulmonary conditions, including pulmonary hypertension in children and adults. However, the widespread use of inhaled NO is limited by logistical and financial barriers. We have designed, developed and tested a simple and economic NO generation device, which uses pulsed electrical discharges in air to produce therapeutic levels of NO that can be used for inhalation therapy. Linked Articles This article is part of a themed section on Nitric Oxide 20 Years from the 1998 Nobel Prize. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.2/issuetoc

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Section: Introductionmentioning

confidence: 99%

Inhaled nitric oxide

Ichinose

Bloch

et al. 2018

British J Pharmacology

Self Cite

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“…In contrast, electrical generation of NO from air provides a simple, safe, and economical solution. NO may play an important role in treating a broad spectrum of diseases, such as in cardiac surgery, heart-lung transplantation, pediatric acute respiratory distress syndrome (ARDS), cerebral malaria, blood transfusion, and cystic fibrosis [5,6].…”

Section: Clinical Values and Potential Applications In The Developingmentioning

confidence: 99%